Translocation 2;11 in a fibroma of tendon sheath
Article first published online: 25 DEC 2001
Volume 32, Issue 5, pages 433–435, May 1998
How to Cite
Dal Cin, Sciot, De Smet and Van Den Berghe (1998), Translocation 2;11 in a fibroma of tendon sheath. Histopathology, 32: 433–435. doi: 10.1046/j.1365-2559.1998.00390.x
- Issue published online: 25 DEC 2001
- Article first published online: 25 DEC 2001
- chromosome change;
- fibroblastic proliferation;
- fibroma of tendon sheath
To determine whether fibromas of tendon sheath represent a reactive fibrosing process or whether they are neoplastic, we investigated the chromosomes of the proliferating cells. A clonally occurring karyotypic abnormality would be an argument in favour of these fibromas being neoplastic.
Methods and results
A biopsy specimen of a fibroma of tendon sheath was cultured after collagenase exposure leading to dissociation of the tissue. The cultured cells were harvested after 4 days and chromosome analysis done according to standard procedures. Ten out of 20 karyotyped cells showed an identical chromosome abnormality characterized by a t(2;11)(q31–32;q12). The other 10 cells showed a normal 46,XX karyotype.
The clonally occurring chromosome abnormality found in this fibroma of tendon sheath suggests that this proliferation is neoplastic and not a reactive fibrosing process.