Xanthogranulomatous cystitis associated with malignant neoplasms of the bladder

Authors

  • A W Bates,

    1. Department of Morbid Anatomy, St Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London, UK
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  • A W Fegan,

    1. Department of Morbid Anatomy, St Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London, UK
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  • S I Baithun

    1. Department of Morbid Anatomy, St Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London, UK
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Dr A W Bates Department of Morbid Anatomy, The Royal London Hospital, London E1 1BB, UK.

Abstract

Aims: Two cases of xanthogranulomatous cystitis in conjunction with malignant neoplasms of the bladder are described.

Methods and results

A partial gastrectomy specimen from a 55-year-old man showed a urachal adenocarcinoma partly surrounded by a large xanthogranulomatous inflammatory mass. Multiple resections of the locally recurring tumour over the subsequent 10 years did not show further xanthogranulomatous changes. In the second case, a 76-year-old woman, a focus of xanthogranulomatous cystitis was present near a moderately differentiated transitional-cell carcinoma of the vesico-ureteric junction.

Conclusions

Xanthogranulomatous inflammation is associated with malignant neoplasms in the bladder, as it is in the kidney and extra-urinary sites, as well as with benign neoplasms and non-neoplastic conditions such as urachal diverticula. The presence of a concomitant neoplasm should therefore be considered when the diagnosis of xanthogranulomatous cystitis is made.

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