Apocrine adenosis of the breast: clonal evidence of neoplasia
Article first published online: 21 DEC 2001
Volume 38, Issue 3, pages 221–224, March 2001
How to Cite
Endoh, Y., Tamura, G., Kato, N. and Motoyama, T. (2001), Apocrine adenosis of the breast: clonal evidence of neoplasia. Histopathology, 38: 221–224. doi: 10.1046/j.1365-2559.2001.01095.x
- Issue published online: 21 DEC 2001
- Article first published online: 21 DEC 2001
- Date of submission 2 June 2000Accepted for publication 8 August 2000
- apocrine adenosis;
- clonal analysis;
We report here a case of apocrine adenosis of the breast in a 66-year-old woman. To clarify the nature of this lesion, we examined it by clonal analysis.
The lesion, 43 mm at its greatest dimension, was ill-circumscribed, lacking a fibrous capsule, and was composed of compact glands that showed typical histological features of apocrine adenosis. Clonality analysis, using the polymerase chain reaction (PCR)-based method for females heterozygous for a BstXI polymorphism of the X-linked phosphoglycerokinase (PGK) gene, revealed the monoclonal nature of the lesion.
This result strongly suggests that some populations of apocrine adenosis are already neoplastic, and this could contribute to the premalignant potential of this lesion.