• 1
    Tokunaga T., Yamamoto H., Shimada S. et al. 1984 Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. J Natl Cancer Inst 72 955
  • 2
    Shimada S., Yano O. & Tokunaga T.1986 In vivo augmentation of natural killer cell activity with a deoxyribonucleic acid fraction of BCG. Jpn J Cancer Res 77 808
  • 3
    Yamamoto S., Kuramoto E., Shimada S. & Tokunaga T.1988 In vitro augmentation of natural killer cell activity and production of interferon-alpha/beta and -gamma with deoxyribonucleic acid fraction from Mycobacterium bovis BCG. Jpn J Cancer Res 79 866
  • 4
    Messina J.P., Gilkeson G.S. & Pisetsky D.S.1991 Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J Immunol 147 1759
  • 5
    Yamamoto S., Yamamoto T., Shimada S. et al. 1992 DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microbiol Immunol 36 983
  • 6
    Tokunaga T., Yano O., Kuramoto E. et al. 1992 Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells. Microbiol Immunol 36 55
  • 7
    Krieg A.M., Yi A.K., Matson S. et al. 1995 CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374 546
  • 8
    Bird A.P.1986 CpG-rich islands and the function of DNA methylation. Nature 321 209
  • 9
    Klinman D.M., Yamshchikov G. & Ishigatsubo Y.1997 Contribution of CpG motifs to the immunogenicity of DNA vaccines. J Immunol 158 3635
  • 10
    Lipford G.B., Heeg K. & Wagner H.1998 Bacterial DNA as immune cell activator. Trends Microbiol 6 496
  • 11
    Stacey K.J., Sweet M.J. & Hume D.A.1996 Macrophages ingest and are activated by bacterial DNA. J Immunol 157 2116
  • 12
    Sato Y., Roman M., Tighe H. et al. 1996 Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273 352
  • 13
    Halpern M.D., Kurlander R.J. & Pisetsky D.S.1996 Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha. Cell Immunol 167 72
  • 14
    Sparwasser T., Miethke T., Lipford G. et al. 1997 Bacterial DNA causes septic shock. Nature 386 336
  • 15
    Lipford G.B., Sparwasser T., Bauer M. et al. 1997 Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines. Eur J Immunol 27 3420
  • 16
    Chace J.H., Hooker N.A., Mildenstein K.L., Krieg A.M. & Cowdery J.S.1997 Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12. Clin Immunol Immunopathol 84 185
  • 17
    Roman M., Martin-Orozco E., Goodman J.S. et al. 1997 Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat Med 3 849
  • 18
    Sparwasser T., Koch E.S., Vabulas R.M. et al. 1998 Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol 28 2045
  • 19
    Lipford G.B., Bauer M., Blank C., Reiter R., Wagner H. & Heeg K.1997 CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur J Immunol 27 2340
  • 20
    Ballas Z.K., Rasmussen W.L. & Krieg A.M.1996 Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J Immunol 157 1840
  • 21
    Yi A.K., Chace J.H., Cowdery J.S. & Krieg A.M.1996 IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides. J Immunol 156 558
  • 22
    Bendigs S., Salzer U., Lipford G.B., Wagner H. & Heeg K.1999 CpG-oligodeoxynucleotides costimulate primary T cells in the absence of APC. Eur J Immunol 291290
  • 23
    Davis H.L., Weeranta R., Waldschmidt T.J., Tygrett L., Schorr J. & Krieg A.M.1998 CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J Immunol 160 870
  • 24
    Chu R.S., Targoni O.S., Krieg A.M., Lehmann P.V. & Harding C.V.1997 CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med 186 1623
  • 25
    Sun S., Kishimoto H. & Sprent J.1998 DNA as an adjuvant: capacity of insect DNA and synthetic oligodeoxynucleotides to augment T cell responses to specific antigen. J Exp Med 187 1145
  • 26
    Zimmermann S., Egeter O., Hausmann S. et al. 1998 CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. J Immunol 160 3627
  • 27
    Kline J.N., Waldschmidt T.J., Businga T.R. et al. 1998 Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J Immunol 160 2555
  • 28
    Yamamoto T., Yamamoto S., Kataoka T., Komuro K., Kohase M. & Tokunaga T.1994 Synthetic oligonucleotides with certain palindromes stimulate interferon production of human peripheral blood lymphocytes in vitro. Jpn J Cancer Res 85 775
  • 29
    Branda R.F., Moore A.L., Hong R., McCormack J.J., Zon G. & Cunningham-Rundles C.1996 B-cell proliferation and differentiation in common variable immunodeficiency patients produced by an antisense oligomer to the rev gene of HIV-1. Clin Immunol Immunopathol 79 115
  • 30
    Liang H., Nishioka Y., Reich C.F., Pisetsky D.S. & Lipsky P.E.1996 Activation of human B cells by phosphorothioate oligodeoxynucleotides. J Clin Invest 98 1119
  • 31
    Ulmer A.J., Feist W., Heine H. et al. 1992 Modulation of endotoxin-induced monokine release in human monocytes by lipid A partial structures that inhibit binding of 125I-lipopolysaccharide. Infect Immun 60 5145
  • 32
    Macfarlane D.E. & Manzel L.1998 Antagonism of immunostimulatory CpG-oligonucleotides by quinicrine, chloroquine, and structurally related compounds. J Immunol 160 1122
  • 33
    Häcker H., Mischak M., Miethke T. et al. 1998 CpG-DNA specific activation of antigen presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J 17 6230