• 1
    Cooper A.M. & Flynn J.L. (1995) The protective immune response to Mycobacterium tuberculosis. Curr Opin Immunol 7, 512.
  • 2
    Bloom B.R. (1994) Tuberculosis. In: Tuberculosis, Pathogenesis, Protection and Control (ed. B. R.Bloom), p. 1–43.A.S.M. Press, New York.
  • 3
    Mosmann T.R. & Coffman R.L. (1989) TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7, 145.
  • 4
    Cooper A.M., Roberts A.D., Rhoades E.R., Callahan J.E., Getzy D.M., Orme I.M. (1995) The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection. Immunology 84, 423.
  • 5
    Cooper A.M., Dalton D.K., Stewart T.A., Griffin J.P., Russell D.G., Orme I.M. (1993) Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 178, 2243.
  • 6
    Cooper A.M., Magram J., Ferrante J., Orme I.M. (1997) Interleukin 12 is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis. J Exp Med 186, 39.
  • 7
    Flynn J.L., Goldstein M.M., Chan J., Triebold K.J., Bloom B.R. (1995) Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 2, 561.
  • 8
    Kamijo R., Le J., Shapiro D. et al. (1993) Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guerin and subsequent challenge with lipopolysaccharide. J Exp Med 178, 1435.
  • 9
    Altare F., Durandy A., Lammas D. et al. (1998) Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science 280, 1432.
  • 10
    De Jong R., Altare F., Haagen I.A. et al. (1998) Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science 280, 1435.
  • 11
    Kindler V., Sappino A.-P., Grau G.E., Piguet P.-F., Vassalli P. (1989) The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection. Cell 56, 731.
  • 12
    Senaldi G., Yin S., Shaklee C.L., Piguet P.-F., Mak T.W., Ulich T.R. (1996) Corynebacterium parvum- and Mycobacterium bovis bacillus Calmette-Guerin-induced granuloma formation is inhibited in TNF receptor 1 (TNF-RI) knockout mice and by treatment with soluble TNF-R1. J Immunol 157, 5022.
  • 13
    Bermudez L.E. & Champsi J. (1993) Infection with Mycobacterium avium induces production of interleukin-10, and administration of anti IL-10 antibody is associated with enhanced resistance in mice. Infect Immun 16, 3093.
  • 14
    Bogdan C. & Nathan C. (1993) Modulation of macrophage function by transforming growth factor beta, interleukin-10. Ann N Y Acad Sci 685, 713.
  • 15
    Murray P.J., Wang L., Onufryk C., Tepper R.I., Young R.A. (1997) T cell-derived IL-10 antagonizes macrophage function mycobacterial infecton. J Immunol 158, 315.
  • 16
    Denis M. & Ghadirian E. (1993) IL-10 neutralization augments mouse resistance to systemic Mycobacterium avium infections. J Immunol 151, 5425.
  • 17
    Erb K.J., Kirman J., Delahunt B., Chen W., Le Gros G. (1998) IL-4, IL-5 and IL-10 are not required for the control of M. bovis-BCG infection in mice . Immunol Cell Biol 76, 41.
  • 18
    North R.J. (1998) Mice incapable of making IL-4 or IL-10 display normal resistance to infection with Mycobacterium tuberculosis. Clin Exp Immunol 113, 55.
  • 19
    Murray P.J. & Young A.Y. (1999) Increased antimycobacterial immunity in interleukin-10-deficient mice. Infect Immun 67, 3087.
  • 20
    Kuhn R., Lohler J., Rennick D., Rajewsky K., Muller W. (1993) Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75, 263.
  • 21
    Ryffel B., Car B.D., Gunn H., Roman D., Mihatsch M.J. (1994) Interleukin-6 exacerbates glomerulonephritis in (NZB x NZW) F1 mice. Am J Pathol 144, 927.
  • 22
    Lucas R., Tacchini-Cottier F., Guler al.1999) A role for lymphotoxin beta receptor in host defence against Mycobacterium bovis BCG infection. Eur J Immunol 29, 4002.DOI: 10.1002/(sici)1521-4141(199912)29:12<4002::aid-immu4002>;2-s
  • 23
    Yang X., Gartner J., Zhu L., Wang S., Brunham R.C. (1999) IL-10 gene knockout mice show enhanced Th1-like protective immunity and absent granulomaa formation following Chlamydia trachomatis lung infection. J Immunol 162, 1010.
  • 24
    Groux H., Cottrez F., Rouleau M., Roncarolo M.G., Coffman R.L. (1998) A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells. J Immunol 162, 1723.