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References

  • 1
    Coca AF, Cooke RA. On the classification of the phenomenon of hypersensitiveness. J Immunol 1923; 8:16382.
  • 2
    Adkinson J. The behavior of bronchial asthma as an inherited character. Genetics 1920; 5:363418.
  • 3
    Cookson WO, Sharp PA, Faux JA, Hopkin JM. Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. Lancet 1989; 1:12925.
  • 4
    Daniels SE, Bhattacharrya S, James A et al. A genome-wide search for quantitative trait loci underlying asthma. Nature 1996; 383:24750.
  • 5
    The Collaborative Study on the Genetics of Asthma. A genome-wide search for asthma susceptibility loci in ethnically diverse populations. The Collaborative Study on the Genetics of Asthma (CSGA). Nat Genet 1997; 15:38992.
  • 6
    Xu J, Meyers DA, Ober C et al. Genomewide screen and identification of gene–gene interactions for asthma-susceptibility loci in three U.S. populations: collaborative study on the genetics of asthma. Am J Hum Genet 2001; 68:143746.
  • 7
    Xu J, Postma DS, Howard TD, Koppelman GH, Zheng SL, Stine OC, Bleecker ER, Meyers DA. Major genes regulating total serum immunoglobulin E levels in families with asthma. Am J Hum Genet 2000; 67:116373.
  • 8
    Dizier MH, Besse-Schmittler C, Guilloud-Bataille M et al. Genome screen for asthma and related phenotypes in the French EGEA study. Am J Respir Crit Care Med 2000; 162:181218.
  • 9
    Wjst M, Fischer G, Immervoll T, Jung M et al. A genome-wide search for linkage to asthma. German Asthma Genetics Group. Genomics 1999; 58:18.
  • 10
    Yokouchi Y, Nukaga Y, Shibasaki M et al. Significant evidence for linkage of mite-sensitive childhood asthma to chromosome 5q31-q33 near the interleukin 12 B locus by a genome-wide search in Japanese families. Genomics 2000; 66:15260.DOI: 10.1006/geno.2000.6201
  • 11
    Ober C, Tsalenko A, Parry R, Cox NJ. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. Am J Hum Genet 2000; 67:115462.
  • 12
    Nishimura A, Campbell-Meltzer RS, Chute K, Orrell J, Ono SJ. Genetics of allergic disease: evidence for organ-specific susceptibility genes. Int Arch Allergy Immunol 2001; 124:197200.
  • 13
    Cookson WO, Young RP, Sandford AJ et al. Maternal inheritance of atopic IgE responsiveness on chromosome 11q. Lancet 1992; 340:3814.
  • 14
    Sandford AJ, Shirakawa T, Moffatt MF et al. Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. Lancet 1993; 341:3324.
  • 15
    Shirakawa T, Li A, Dubowitz M et al. Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor. Nat Genet 1994; 7:1259.
  • 16
    Hizawa N, Freidhoff LR, Ehrlich E et al. Genetic influences of chromosomes 5q31-q33 and 11q13 on specific IgE responsiveness to common inhaled allergens among African American families. Collaborative Study on the Genetics of Asthma (CSGA). J Allergy Clin Immunol 1998; 102:44953.
  • 17
    Palmer LJ, Daniels SE, Rye PJ et al. Linkage of chromosome 5q and 11q gene markers to asthma-associated quantitative traits in Australian children. Am J Respir Crit Care Med 1998; 158:182530.
  • 18
    Shirakawa T, Hashimoto T, Furuyama J, Takeshita T, Morimoto K. Linkage between severe atopy and chromosome 11q13 in Japanese families. Clin Genet 1994; 46:22832.
  • 19
    Folster-Holst R, Moises HW, Yang L, Fritsch W, Weissenbach J, Christophers E. Linkage between atopy and the IgE high-affinity receptor gene at 11q13 in atopic dermatitis families. Hum Genet 1998; 102:2369.DOI: 10.1007/s004390050685
  • 20
    Malerba G, Trabetti E, Patuzzo C, Lauciello MC, Galavotti R, Pescollderungg L, Boner AL, Pignatti PF. Candidate genes and a genome-wide search in Italian families with atopic asthmatic children. Clin Exp Allergy 1999; 29:2730.
  • 21
    Soderhall C, Bradley M, Kockum I, Wahlgren CF, Luthman H, Nordenskjold M. Linkage and association to candidate regions in Swedish atopic dermatitis families. Hum Genet 2001; 109:12935.
  • 22
    Green SL, Gaillard MC, Song E, Dewar JB, Halkas A. Polymorphisms of the beta chain of the high-affinity immunoglobulin E receptor (Fcepsilon RI-beta) in South African black and white asthmatic and nonasthmatic individuals. Am J Respir Crit Care Med 1998; 158:148792.
  • 23
    Hill MR, Cookson WO. A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness. Hum Mol Genet 1996; 5:95962.
  • 24
    Laprise C, Boulet LP, Morissette J, Winstall E, Raymond V. Evidence for association and linkage between atopy, airway hyper-responsiveness, and the beta subunit Glu237Gly variant of the high-affinity receptor for immunoglobulin E in the French-Canadian population. Immunogenetics 2000; 51:695702.DOI: 10.1007/s002510000185
  • 25
    Brereton HM, Ruffin RE, Thompson PJ, Turner DR. Familial atopy in Australian pedigrees: adventitious linkage to chromosome 8 is not confirmed nor is there evidence of linkage to the high affinity IgE receptor. Clin Exp Allergy 1994; 24:86877.
  • 26
    Rich SS, Roitman-Johnson B, Greenberg B, Roberts S, Blumenthal MN. Genetic analysis of atopy in three large kindreds: no evidence of linkage to D11S97. Clin Exp Allergy 1992; 22:10706.
  • 27
    Amelung PJ, Panhuysen CI, Postma DS, Levitt RC, Koeter GH, Francomano CA, Bleecker ER, Meyers DA. Atopy and bronchial hyperresponsiveness: exclusion of linkage to markers on chromosomes 11q and 6p. Clin Exp Allergy 1992; 22:107784.
  • 28
    Lympany P, Welsh K, MacCochrane G, Kemeny DM, Lee TH. Genetic analysis using DNA polymorphism of the linkage between chromosome 11q13 and atopy and bronchial hyperresponsiveness to methacholine. J Allergy Clin Immunol 1992; 89:61928.
  • 29
    Hizawa N, Yamaguchi E, Ohe M, Itoh A, Furuya K, Ohnuma N, Kawakami Y. Lack of linkage between atopy and locus 11q13. Clin Exp Allergy 1992; 22:10659.
  • 30
    Torres-Galvan MJ, Quiralte J, Pestano JJ. IL4–R1 (5q31-q33) and FcepsilonRI-betaca (11q13) markers and atopy: a case/control study in a spanish population. Allergy 2001; 56:15963.DOI: 10.1034/j.1398-9995.2001.056002159.x
  • 31
    Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Xu J, Panhuysen CI, Meyers DA, Levitt RC. Genetic susceptibility to asthma-bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med 1995; 333:894900.
  • 32
    Bleecker ER, Amelung PJ, Levitt RC, Postma DS, Meyers DA. Evidence for linkage of total serum IgE and bronchial hyperresponsiveness to chromosome 5q: a major regulatory locus important in asthma. Clin Exp Allergy 1995; 25:848.
  • 33
    Noguchi E, Shibasaki M, Arinami T et al. Evidence for linkage between asthma/atopy in childhood and chromosome 5q31-q33 in a Japanese population. Am J Respir Crit Care Med 1997; 156:13903.
  • 34
    Beyer K, Nickel R, Freidhoff L et al. Association and linkage of atopic dermatitis with chromosome 13q12–14 and 5q31–33 markers. J Invest Dermatol 2000; 115:9068.
  • 35
    Shek LP, Tay AH, Chew FT, Goh DL, Lee BW. Genetic susceptibility to asthma and atopy among Chinese in Singapore – linkage to markers on chromosome 5q31–33. Allergy 2001; 56:74953.
  • 36
    Blumenthal MN, Wang Z, Weber JL, Rich SS. Absence of linkage between 5q markers and serum IgE levels in four large atopic families. Clin Exp Allergy 1996; 26:8926.
  • 37
    Kamitani A, Wong ZY, Dickson P et al. Absence of genetic linkage of chromosome 5q31 with asthma and atopy in the general population. Thorax 1997; 52:81617.
  • 38
    Mansur AH, Bishop DT, Markham AF, Britton J, Morrison JF. Association study of asthma and atopy traits and chromosome 5q cytokine cluster markers. Clin Exp Allergy 1998; 28:14150.DOI: 10.1046/j.1365-2222.1998.00229.x
  • 39
    Holberg CJ, Halonen M, Solomon S, Graves PE, Baldini M, Erickson RP, Martinez FD. Factor analysis of asthma and atopy traits shows 2 major components, one of which is linked to markers on chromosome 5q. J Allergy Clin Immunol 2001; 108:77280.
  • 40
    McIntire JJ, Umetsu SE, Akbari O et al. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol 2001; 2:110916.DOI: 10.1038/ni739
  • 41
    Marsh DG, Neely JD, Breazeale DR et al. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 1994; 264:11526.
  • 42
    Song Z, Casolaro V, Chen R, Georas SN, Monos D, Ono SJ. Polymorphic nucleotides within the human IL-4 promoter that mediate overexpression of the gene. J Immunol 1996; 156:4249.
  • 43
    Hook S, Cheng P, Holloway J, Riley G, Sawyer G, Le Gros G, Beasley R. Analysis of two IL-4 promoter polymorphisms in a cohort of atopic and asthmatic subjects. Exp Clin Immunogenet 1999; 16:335.
  • 44
    Suzuki I, Hizawa N, Yamaguchi E, Kawakami Y. Association between a C+33T polymorphism in the IL-4 promoter region and total serum IgE levels. Clin Exp Allergy 2000; 30:17469.DOI: 10.1046/j.1365-2222.2000.00983.x
  • 45
    Shirakawa T, Deichmann KA, Izuhara I, Mao I, Adra CN, Hopkin JM. Atopy and asthma: genetic variants of IL-4 and IL-13 signalling. Immunol Today 2000; 21:604.
  • 46
    Rosenwasser LJ, Borish L. Genetics of atopy and asthma: the rationale behind promoter-based candidate gene studies (IL-4 and IL-10). Am J Respir Crit Care Med 1997; 156:S1525.
  • 47
    Noguchi E, Shibasaki M, Arinami T et al. Association of asthma and the interleukin-4 promoter gene in Japanese. Clin Exp Allergy 1998; 28:44953.DOI: 10.1046/j.1365-2222.1998.00256.x
  • 48
    Walley AJ, Cookson WO. Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy. J Med Genet 1996; 33:68992.
  • 49
    Dizier MH, Sandford A, Walley A, Philippi A, Cookson W, Demenais F. Indication of linkage of serum IgE levels to the interleukin-4 gene and exclusion of the contribution of the (−590 C to T) interleukin-4 promoter polymorphism to IgE variation. Genet Epidemiol 1999; 16:8494.
  • 50
    Hijazi Z, Haider MZ. Interleukin-4 gene promoter polymorphism [C590T] and asthma in Kuwaiti Arabs. Int Arch Allergy Immunol 2000; 122:1904.
  • 51
    Elliott K, Fitzpatrick E, Hill D et al. The −590C/T and −34C/T interleukin-4 promoter polymorphisms are not associated with atopic eczema in childhood. J Allergy Clin Immunol 2001; 108:2857.
  • 52
    Grunig G, Warnock M, Wakil AE et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998; 282:22613.
  • 53
    Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD. Interleukin-13: central mediator of allergic asthma. Science 1998; 282:225861.DOI: 10.1126/science.282.5397.2258
  • 54
    Van Der Pouw Kraan TC, Van Veen A, Boeije Lc et al. An IL-13 promoter polymorphism associated with increased risk of allergic asthma. Genes Immun 1999; 1:615.
  • 55
    Heinzmann A, Mao XQ, Akaiwa M et al. Genetic variants of IL-13 signalling and human asthma and atopy. Hum Mol Genet 2000; 9:54959.
  • 56
    Graves PE, Kabesch M, Halonen M et al. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J Allergy Clin Immunol 2000; 105:50613.
  • 57
    Pantelidis P, Jones MG, Welsh KI, Taylor AN, Du Bois RM. Identification of four novel interleukin-13 gene polymorphisms. Genes Immun 2000; 1:3415.
  • 58
    Liu X, Nickel R, Beyer K et al. An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German multicenter atopy study (MAS-90). J Allergy Clin Immunol 2000; 106:16770.
  • 59
    Howard TD, Whittaker PA, Zaiman AL et al. Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population. Am J Respir Cell Mol Biol 2001; 25:37784.
  • 60
    Leung TF, Tang NL, Chan IH, Li AM, Ha G, Lam CW. A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese children. Clin Exp Allergy 2001; 31:151521.
  • 61
    Ober C, Leavitt SA, Tsalenko A et al. Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations. Am J Hum Genet 2000; 66:51726.
  • 62
    Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N Engl J Med 1997; 337:17205.
  • 63
    Oiso N, Fukai K, Ishii M. Interleukin 4 receptor alpha chain polymorphism Gln551Arg is associated with adult atopic dermatitis in Japan. Br J Dermatol 2000; 142:10036.
  • 64
    Wang HY, Shelburne CP, Zamorano J, Kelly AE, Ryan JJ, Keegan AD. Effects of an allergy-associated mutation in the human IL-4R alpha (Q576R) on human IL-4-induced signal transduction. J Immunol 1999; 162:43859.
  • 65
    Grimbacher B, Holland SM, Puck JM. The interleukin-4 receptor variant Q576R in hyper-IgE syndrome. N Engl J Med 1998; 338:10734.
  • 66
    Noguchi E, Shibasaki M, Arinami T et al. Lack of association of atopy/asthma and the interleukin-4 receptor alpha gene in Japanese. Clin Exp Allergy 1999; 29:22833.DOI: 10.1046/j.1365-2222.1999.00458.x
  • 67
    Mitsuyasu H, Izuhara K, Mao XQ et al. Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma. Nat Genet 1998; 19:11920.DOI: 10.1038/472
  • 68
    Mitsuyasu H, Yanagihara Y, Mao XQ et al. Dominant effect of Ile50Val variant of the human IL-4 receptor alpha-chain in IgE synthesis. J Immunol 1999; 162:122731.
  • 69
    Kruse S, Japha T, Tedner M, Sparholt SH, Forster J, Kuehr J, Deichmann KA. The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction. Immunology 1999; 96:36571.
  • 70
    Andrews RP, Burrell L, Rosa-Rosa L, Cunningham CM, Brzezinski JL, Bernstein JA, Khurana Hershey GK. Analysis of the Ser786Pro interleukin-4 receptor alpha allelic variant in allergic and nonallergic asthma and its functional consequences. Clin Immunol 2001; 100:298304.DOI: 10.1006/clim.2001.5082
  • 71
    Hizawa N, Freidhoff LR, Chiu YF et al. Genetic regulation of Dermatophagoides pteronyssinus-specific IgE responsiveness: a genome-wide multipoint linkage analysis in families recruited through 2 asthmatic sibs. Collaborative Study on the Genetics of Asthma (CSGA). J Allergy Clin Immunol 1998; 102:43642.
  • 72
    Van Neerven RJ. The role of allergen-specific T cells in the allergic immune response: relevance to allergy vaccination. Allergy 1999; 54:55261.
  • 73
    Matsushita S, Muto M, Suemura M, Saito Y, Sasazuki T. HLA-linked nonresponsiveness to Cryptomeria japonica pollen antigen. I. Nonresponsiveness is mediated by antigen-specific suppressor T cell. J Immunol 1987; 138:10915.
  • 74
    Caraballo L, Marrugo J, Jimenez S, Angelini G, Ferrara GB. Frequency of DPB1*0401 is significantly decreased in patients with allergic asthma in a mulatto population. Hum Immunol 1991; 32:15761.
  • 75
    Lara-Marquez ML, Yunis JJ, Layrisse Z et al. Immunogenetics of atopic asthma: association of DRB1*1101 DQA1*0501 DQB1*0301 haplotype with Dermatophagoides spp.-sensitive asthma in a sample of the Venezuelan population. Clin Exp Allergy 1999; 29:6071.DOI: 10.1046/j.1365-2222.1999.00461.x
  • 76
    Kim YK, Oh HB, Oh SY, Cho SH, Kim YY, Min KU. HLA-DRB1*07 may have a susceptibility and DRB1*04 a protective effect upon the development of a sensitization to house dust mite Dermatophagoides pteronyssinus. Clin Exp Allergy 2001; 31:11015.
  • 77
    Nickel RG, Casolaro V, Wahn U et al. Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES. J Immunol 2000; 164:161216.
  • 78
    Fryer AA, Spiteri MA, Bianco A et al. The −403 G[RIGHTWARDS ARROW]A promoter polymorphism in the RANTES gene is associated with atopy and asthma. Genes Immun 2000; 1:50914.
  • 79
    Szalai C, Kozma GT, Nagy A, Bojszko AA, Krikovszky D, Szabo T, Falus A. Polymorphism in the gene regulatory region of MCP-1 is associated with asthma susceptibility and severity. J Allergy Clin Immunol 2001; 108:37581.
  • 80
    Lee YA, Wahn U, Kehrt R et al. A major susceptibility locus for atopic dermatitis maps to chromosome 3q21. Nat Genet 2000; 26:4703.DOI: 10.1038/82625
  • 81
    Mitchell TJ, Walley AJ, Pease JE, Venables PJ, Wiltshire S, Williams TJ, Cookson WO. Delta 32 deletion of CCR5 gene and association with asthma or atopy. Lancet 2000; 356:14912.
  • 82
    Casolaro V, Keane-Myers AM, Swendeman SL, Steindler C, Zhong F, Sheffery M, Georas SN, Ono SJ. Identification and characterization of a critical CP2-binding element in the human interleukin-4 promoter. J Biol Chem 2000; 275:3660511.
  • 83
    Takeda K, Tanaka T, Shi W et al. Essential role of Stat6 in IL-4 signaling. Nature 1996; 380:62730.
  • 84
    Shimoda K, Van Deursen J, Sangster MY et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996; 380:6303.
  • 85
    Gao PS, Mao XQ, Roberts MH et al. Variants of STAT6 (signal transducer and activator of transcription 6) in atopic asthma. J Med Genet 2000; 37:3802.
  • 86
    Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 1997; 276:5892.
  • 87
    Adra CN, Gao PS, Mao XQ, Baron BW, Pauker S, Miki T, Shirakawa T, Hopkin JM. Variants of B cell lymphoma 6 (BCL6) and marked atopy. Clin Genet 1998; 54:3624.
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  • 88
    Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100:65569.
  • 89
    Zhang DH, Cohn L, Ray P, Bottomly K, Ray A. Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J Biol Chem 1997; 272:21597603.
  • 90
    Kishikawa H, Sun J, Choi A, Miaw SC, Ho IC. The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3. J Immunol 2001; 167:4441420.
  • 91
    Finotto S, Neurath MF, Glickman JN et al. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 2002; 295:3368.
  • 92
    Nakamura Y, Ghaffar O, Olivenstein R, Taha RA, Soussi-Gounni A, Zhang DH, Ray A, Hamid Q. Gene expression of the GATA-3 transcription factor is increased in atopic asthma. J Allergy Clin Immunol 1999; 103:21522.
  • 93
    Lander ES, Linton LM, Birren B et al. Initial sequencing and analysis of the human genome. Nature 2001; 409:860921.DOI: 10.1038/35057062
  • 94
    Vender JC, Adams MD, Myers EW et al. The sequence of the human genome. Science 2001; 291:130451.
  • 95
    Brutsche MH, Brutsche IC, Wood P, Mogulkoc N, Custovic A, Egan J, Woodcock A. B-cell isotype control in atopy and asthma assessed with cDNA array technology. Am J Physiol Lung Cell Mol Physiol 2001; 280:L62737.
  • 96
    Brutsche MH, Brutsche IC, Wood P et al. Apoptosis signals in atopy and asthma measured with cDNA arrays. Clin Exp Immunol 2001; 123:1817.
  • 97
    Karp CL, Grupe A, Schadt E et al. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nat Immunol 2000; 1:2216.
  • 98
    Westergren-Thorsson G, Malmstrom J, Marko-Varga G. Proteomics – the protein expression technology to study connective tissue biology. J Pharm Biomed Anal 2001; 24:81524.