CD20-mediated apoptosis: signalling through lipid rafts
Article first published online: 16 OCT 2002
Volume 107, Issue 2, pages 176–182, October 2002
How to Cite
Deans, J. P., Li, H. and Polyak, M. J. (2002), CD20-mediated apoptosis: signalling through lipid rafts. Immunology, 107: 176–182. doi: 10.1046/j.1365-2567.2002.01495.x
- Issue published online: 16 OCT 2002
- Article first published online: 16 OCT 2002
- Received 21 June 2002; accepted 27 June 2002.
CD20 is an effective target for therapeutic B-cell depletion with monoclonal antibodies. One proposed mechanism of action is direct cytotoxicity mediated via tyrosine kinase-dependent signalling pathways activated upon CD20 cross-linking. The association of CD20 with membrane microdomains known as lipid rafts, enriched in src-family tyrosine kinases and other signalling effectors, suggests an indirect mechanism of anti-CD20-induced apoptosis in which activation of src-family kinases occurs as a consequence of lipid raft clustering.