Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue
Article first published online: 10 JAN 2003
Volume 108, Issue 1, pages 10–15, January 2003
How to Cite
Ochoa, M.-T., Legaspi, A. J., Hatziris, Z., Godowski, P. J., Modlin, R. L. and Sieling, P. A. (2003), Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue. Immunology, 108: 10–15. doi: 10.1046/j.1365-2567.2003.01563.x
- Issue published online: 10 JAN 2003
- Article first published online: 10 JAN 2003
- Received 24 April 2002; revised 9 August 2002; accepted 10 October 2002.
To determine how distinct receptors of the immune system can contribute to innate immunity, we investigated the pattern of Toll-like receptor 1 (TLR1) and TLR2 expression in human lymphoid tissue. We found that TLR1 and TLR2 were co-expressed on cells of the innate immune system, including macrophages and dendritic cells. In addition, TLR1 and TLR2 were expressed in mucosa-associated lymphoid tissue on tonsillar crypt epithelium. Of the lymphoid tissue examined, spleen expressed the highest levels of TLR2. Although TLR1- and TLR2-positive cells were in close proximity to T lymphocytes in vivo, lymphocytes themselves were devoid of TLR1 and TLR2 expression. The co-expression of TLR1 and TLR2 on myeloid cells in lymphoid tissue provides the host with the ability to respond to a variety of microbial ligands at sites conducive to the generation of an immune response.