• 1
    Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392 : 24552.
  • 2
    Lane PJ, Brocker T. Developmental regulation of dendritic cell function. Curr Opin Immunol 1999; 11 : 30813.
  • 3
    Hart DN. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 1997; 90 : 324587.
  • 4
    Lipscomb MF, Masten BJ. Dendritic cells: immune regulators in health and disease. Physiol Rev 2002; 82 : 97130.
  • 5
    Aiba S, Manome H, Yoshino Y, Tagami H. In vitro treatment of human transforming growth factor-β1-treated monocyte-derived dendritic cells with haptens can induce the phenotypic and functional changes similar to epidermal Langerhans' cells in the initiation phase of allergic contact sensitivity reaction. Immunology 2000; 101 : 6875.
  • 6
    Manome H, Aiba S, Tagami H. Simple chemicals can induce maturation and apoptosis of dendritic cells. Immunology 1999; 98 : 48190.
  • 7
    Aiba S, Terunuma A, Manome H, Tagami H. Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co-stimulatory molecules. Eur J Immunol 1997; 27 : 30318.
  • 8
    Kalinski P, Schuitemaker JH, Hilkens CM, Wierenga EA, Kapsenberg ML. Final maturation of dendritic cells is associated with impaired responsiveness to IFN-γ and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells. J Immunol 1999; 162 : 32316.
  • 9
    Sato K, Nagayama H, Tadokoro K, Juji T, Takahashi TA. Extracellular signal-regulated kinase, stress-activated protein kinase/c-Jun N-terminal kinase, and p38mapk are involved in IL-10-mediated selective repression of TNF-α-induced activation and maturation of human peripheral blood monocyte-derived dendritic cells. J Immunol 1999; 162 : 386572.
  • 10
    Arrighi JF, Rebsamen M, Rousset F, Kindler V, Hauser C. A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-α, and contact sensitizers. J Immunol 2001; 166 : 383745.
  • 11
    Ardeshna KM, Pizzey AR, Devereux S, Khwaja A. The PI3 kinase, p38 SAP kinase, and NF-κB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells. Blood 2000; 96 : 103946.
  • 12
    Puig-Kroger A, Relloso M, Fernandez-Capetillo O, Zubiaga A, Silva A, Bernabeu C, Corbi AL. Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells. Blood 2001; 98 : 217582.
  • 13
    Han J, Lee JD, Bibbs L, Ulevitch RJ. A MAPkinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 1994; 265 : 80811.
  • 14
    Lee JC, Laydon JT, McDonnell PC et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1994; 372 : 73946.
  • 15
    Cobb MH. An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control. Science 1990; 249 : 647.
  • 16
    Boulton TG, Nye SH, Robbins DJ et al. Extracellular signal-related kinses (ERKs): a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and nerve growth factor (NGF). Cell 1991; 65 : 66375.
  • 17
    Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 1994; 76 : 102537.
  • 18
    Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J, Woodgett JR. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 1994; 369 : 15660.
  • 19
    Chan ED, Winston BW, Jarpe MB, Wynes MW, Riches DWH. Preferential activation of the p46 isoform of JNK/SAPK in mouse macrophages by tumor necrosis factor (TNF)-α. Proc Natl Acad Sci USA 1997; 94 : 1316974.
  • 20
    Reinhard C, Shamoon B, Shyamala V, Williams LT. Tumor necrosis factor-induced activation of c-jun N-terminal kinase is mediated by TRAF-2. EMBO J 1997; 16 : 108092.
  • 21
    Song HY, Regnier CH, Kirshning CJ, Goeddel DV, Rothe M. Tumor necrosis factor (TNF)-mediated kinase cascade: bifurcation of nuclear factor-B and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc Natl Acad Sci USA 1997; 94 : 97926.
  • 22
    Winston BW, Chan ED, Johnson GL, Riches DWH. Activation of p38MAPK, MKK3, and MKK4 by TNF-α in mouse bone marrow-derived macrophages. J Immunol 1997; 159 : 44917.
  • 23
    Winzler C, Rovere P, Rescigno M et al. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J Exp Med 1997; 185 : 31728.
  • 24
    Rescigno M, Martino M, Sutherland CL, Gold MR, Ricciardi-Castagnoli P. Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med 1998; 188 : 217580.
  • 25
    Rescigno M, Piguet V, Valzasina B et al. Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1β, and the production of interferon-γ in the absence of IL-12 during DC–T cell cognate interaction: a new role for Fas ligand in inflammatory responses. J Exp Med 2000; 192 : 16618.
  • 26
    Schuurhuis DH, Laban S, Toes RE et al. Immature dendritic cells acquire CD8(+) cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or -dependent stimuli. J Exp Med 2000; 192 : 14550.
  • 27
    Rescigno M, Urbano M, Valzasina B et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2001; 2 : 3617.
  • 28
    Villadangos JA, Cardoso M, Steptoe RJ, Van Berkel D, Pooley J, Carbone FR, Shortman K. MHC class II expression is regulated in dendritic cells independently of invariant chain degradation. Immunity 2001; 14 : 73949.
  • 29
    Yanagawa Y, Iijima N, Iwabuchi K, Onoé K. Activation of extracellular signal-related kinase by TNF-α controls the maturation and function of murine dendritic cells. J Leukoc Biol 2002; 71 : 12532.
  • 30
    Yanagawa Y, Onoé K. CCL19 induces rapid dendritic extension of murine dendritic cells. Blood 2002; 100 : 194856.
  • 31
    Yanagawa Y, Onoé K. CCR7 ligands induce rapid endocytosis in mature dendritic cells with concomitant upregulation of Cdc42 and Rac activities. Blood 2003; 101 : 49239.
  • 32
    Kikuchi K, Yanagawa Y, Aranami T, Iwabuchi C, Iwabuchi K, Onoé K. Tumour necrosis factor-α but not lipopolysaccharide enhances preference of murine dendritic cells for Th2 differentiation. Immunology 2003; 108 : 429.
  • 33
    Huang A, Xiao H, Samii JM, Vita JA, Keaney JF Jr. Contrasting effects of thiol-modulating agents on endothelial NO bioactivity. Am J Physiol Cell Physiol 2001; 281 : C71925.
  • 34
    Ishii M, Yamamoto T, Shimizu S, Sano A, Momose K, Kuroiwa Y. Possible involvement of nitric oxide synthase in oxidative stress-induced endothelial cell injury. Pharmacol Toxicol 1997; 80 : 1916.
  • 35
    Abordo EA, Minhas HS, Thornalley PJ. Accumulation of α-oxoaldehydes during oxidative stress: a role in cytotoxicity. Biochem Pharmacol 1999; 58 : 6418.
  • 36
    Yanagawa Y, Iwabuchi K, Onoé K. Enhancement of stromal cell-derived factor-1α-induced chemotaxis for CD4/8 double-positive thymocytes by fibronectin and laminin in mice. Immunology 2001; 104 : 439.
  • 37
    Whitekus MJ, Li N, Zhang M et al. Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization. J Immunol 2002; 168 : 25607.
  • 38
    Cuzzocrea S, Mazzon E, Dugo L, Serraino I, Ciccolo A, Centorrino T, De Sarro A, Caputi AP. Protective effects of N-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat. FASEB J 2001; 15 : 1187200.
  • 39
    Aiba S, Manome H, Nakagawa S, Mollah ZU, Mizuashi M, Ohtani T, Yoshino Y, Tagami H. p38 mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene. J Invest Dermatol 2003; 120 : 3909.
  • 40
    Arner ES, Bjornstedt M, Holmgren A. 1-Chloro-2,4-dinitrobenzene is an irreversible inhibitor of human thioredoxin reductase: loss of thioredoxin disulfide reductase activity is accompanied by a large increase in NADPH oxidase activity. J Biol Chem 1995; 270 : 347982.
  • 41
    Nordberg J, Zhong L, Holmgren A, Arner ES. Mammalian thioredoxin reductase is irreversibly inhibited by dinitrohalobenzenes by alkylation of both the redox active selenocysteine and its neighboring cysteine residue. J Biol Chem 1998; 273 : 1083542.
  • 42
    Hsu HY, Wen MH. Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression. J Biol Chem 2002; 277 : 221319.
  • 43
    Sanlioglu S, Williams CM, Samavati L et al. Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-α secretion through IKK regulation of NF-κB. J Biol Chem 2001; 276 : 3018898.
  • 44
    Mostert V, Hill KE, Burk RF. Loss of activity of the selenoenzyme thioredoxin reductase causes induction of hepatic heme oxygenase-1. FEBS Lett 2003; 541 : 858.