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The D7 family of salivary proteins in blood sucking diptera


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    Present addresses: Celera Genomics, 45 West Gude Drive, Rockville, MD 200850, USA; †University of California at Irvine, Department of Molecular Biology and Biochemistry, 3205 Biosc. II, Irvine, CA 92697-3900, USA.

José M. C. Ribeiro, Building 4 rm. 126, 4 Center Dr MSC 0425, Bethesda MD 20892-0425, USA. Tel.: (301)-496-3066; fax: (301)-402-4941; e-mail:


The D7 subfamily of salivary proteins is widespread in blood sucking Diptera and belongs to the superfamily of pheromone/odourant binding proteins. Although D7 proteins are among the most abundant salivary proteins in adult female mosquitoes and sand flies, their role in blood feeding remains elusive. In the present work we report the sequence of seventeen novel D7 proteins, and propose an evolutionary scenario for the appearance of the several forms of this protein, based on a total of twenty-one sequences from Culex quinquefasciatus, Aedes aegypti, Anopheles gambiae, An. arabiensis, An. stephensi, An. darlingi mosquitoes and Lutzomyia longipalpis and Phlebotomus papatasi sand flies.