Identification of a distinct family of genes encoding atypical odorant-binding proteins in the malaria vector mosquito, Anopheles gambiae
Article first published online: 18 NOV 2003
Insect Molecular Biology
Volume 12, Issue 6, pages 549–560, December 2003
How to Cite
Xu, P. X., Zwiebel, L. J. and Smith, D. P. (2003), Identification of a distinct family of genes encoding atypical odorant-binding proteins in the malaria vector mosquito, Anopheles gambiae. Insect Molecular Biology, 12: 549–560. doi: 10.1046/j.1365-2583.2003.00440.x
- Issue published online: 18 NOV 2003
- Article first published online: 18 NOV 2003
- Received 28 March 2003; accepted after revision 9 July 2003.
We performed a genome-wide analysis for candidate odorant-binding protein (OBP) genes in the malaria vector Anopheles gambiae (Ag). We identified fifty-seven putative genes including sixteen genes predicted to encode distinct, higher molecular weight proteins that lack orthologues in Drosophila. Expression analysis indicates that several of these atypical AgOBPs are transcribed in chemosensory organs in adult and immature stages. Phylogenetic analysis of the Anopheles and Drosophila OBP families reveals these proteins fall into several clusters based on sequence similarity and suggests the atypical AgOBP genes arose in the mosquito lineage after the divergence of mosquitoes and flies. The identification of these AgOBP genes is the first step towards determining their biological roles in this economically and medically important insect.