Molecular characterization of arrestin family members in the malaria vector mosquito, Anopheles gambiae
Article first published online: 18 NOV 2003
Insect Molecular Biology
Volume 12, Issue 6, pages 641–650, December 2003
How to Cite
Merrill, C. E., Pitts, R. J. and Zwiebel, L. J. (2003), Molecular characterization of arrestin family members in the malaria vector mosquito, Anopheles gambiae. Insect Molecular Biology, 12: 641–650. doi: 10.1046/j.1365-2583.2003.00450.x
- Issue published online: 18 NOV 2003
- Article first published online: 18 NOV 2003
- Received 26 March 2003; accepted after revision 5 August 2003.
Olfaction influences many insect behaviours including mate seeking and host selection. The molecular machinery underlying insect olfactory systems is a G protein-coupled receptor pathway that, in addition to activation, requires adaptation for olfactory sensitivity and discrimination. We have previously identified ARR1 (henceforth AgARR1), a sensory arrestin from the malaria vector mosquito Anopheles gambiae that has been postulated to modulate olfactory adaptation. This report describes three additional arrestin family members including ARR2 (henceforth AgARR2), which is similar to previously characterized insect sensory arrestins and is expressed at significantly higher levels in the antennae of male vs. female A. gambiae mosquitoes. This finding is consistent with the hypothesis that AgARR2 may be important for the regulation of olfactory-driven behaviours particular to male mosquitoes.