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Efficacy of permethrin-impregnated uniforms in the prevention of cutaneous leishmaniasis in Iranian soldiers
Article first published online: 10 JUN 2003
DOI: 10.1046/j.1365-2710.2003.00476.x
1365-2710/asset/cover.gif?v=1&s=27089b9a8052459ae6fd29a17ddd5ca4e94ca963 "Journal of Clinical Pharmacy and Therapeutics")
Additional Information
How to Cite
Asilian, A., Sadeghinia, A., Shariati, F., Imam Jome, M. and Ghoddusi, A. (2003), Efficacy of permethrin-impregnated uniforms in the prevention of cutaneous leishmaniasis in Iranian soldiers. Journal of Clinical Pharmacy and Therapeutics, 28: 175–178. doi: 10.1046/j.1365-2710.2003.00476.x
Publication History
- Issue published online: 10 JUN 2003
- Article first published online: 10 JUN 2003
- Received 4 February 2003, Accepted 18 March 2003
- Abstract
- Article
- References
- Cited By
Keywords:
- leishmaniasis;
- permethrin;
- prevention
Summary
Background: One approach for prevention of cutaneous leishmaniasis (CL) is the creation of a barrier between the insect vector (phlebotoms) and the host. Many but not all researchers claim that permethrin-impregnated uniforms are effective for prevention of CL. We determined the efficacy of permethrin-impregnated uniforms for prevention of CL in Iranian soldiers.
Methods: A total of 324 soldiers were randomized to two equal groups, of which 272 soldiers completed the study. In group A, 134 soldiers were issued permethrin-impregnated uniforms. In group B, 138 soldiers were issued uniforms washed in water. The soldiers wore uniforms day and night for 3 months, and were observed for an additional period of 6 months. All the soldiers remained in the leishmania-endemic area of Isfahan during the 3 months.
Results: Nine (6·5%) of 138 soldiers wearing control uniforms and six (4·4%) of 134 soldiers wearing permathrin-impregnated uniforms acquired CL. The difference between two groups was not statistically significant (P < 0·05).
Conclusion: Permethrin-impregnated uniforms are not effective for the prevention of CL.