Safety, acceptability and efficacy of a high-energy, fibre-containing oral nutritional supplement in malnourished patients: an observational study
Article first published online: 25 DEC 2001
Journal of Human Nutrition and Dietetics
Volume 13, Issue 4, pages 255–263, August 2000
How to Cite
Mayr, P., Kalde, S., Vogt, M. and Kuhn, K. S. (2000), Safety, acceptability and efficacy of a high-energy, fibre-containing oral nutritional supplement in malnourished patients: an observational study. Journal of Human Nutrition and Dietetics, 13: 255–263. doi: 10.1046/j.1365-277x.2000.00236.x
- Issue published online: 25 DEC 2001
- Article first published online: 25 DEC 2001
- Accepted May 2000
- mass index;
- nutritional status;
- nutritional support;
- supplementary feeding
We describe an open, uncontrolled, observational study to evaluate the safety, acceptability and efficacy of a high-energy, fibre-containing oral nutritional supplement in patients who were either malnourished or who had experienced recent, acute weight loss and therefore needed a high-energy and/or fibre supplement.
Assessments For assessment of safety and tolerance, occurrence of adverse events and oedema were to be documented during the 2-week trial and routine blood biochemistry was measured. The acceptability of the oral nutritional supplement was rated by the patients. In order to assess efficacy, patients’ body mass index (BMI) was calculated at baseline and following 2 weeks of nutritional intervention.
Results A daily intake of 400–600 mL of a high-energy, fibre-containing liquid nutritional supplement was well accepted and no adverse events or problems with compliance were recorded. The high acceptability was underlined by favourable ratings of taste, smell, texture and overall acceptability. The patients’ median (interquartile range) BMI increased from 18 kg m–2 (18–19 kg m–2) to 20 kg m–2 (19–20 kg m–2); this increase was highly significant (P < 0.001).
Conclusion We conclude that a high-energy, fibre-containing nutritional supplement is safe, well tolerated and associated with improved nutritional status in malnourished patients.