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Clostridium difficile colitis associated with a ‘triple’ regimen, containing clarithromycin and metronidazole, to eradicate Helicobacter pylori
Article first published online: 9 OCT 2008
DOI: 10.1046/j.1365-2796.1998.00272.x
Blackwell Science Ltd, 1997
1365-2796/asset/cover.gif?v=1&s=cacbc88a827c8cece634c3d912e9e672c5a697b5 "Journal of Internal Medicine")
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How to Cite
Archimandritis, Souyioultzis, Katsorida and Tzivras (1998), Clostridium difficile colitis associated with a ‘triple’ regimen, containing clarithromycin and metronidazole, to eradicate Helicobacter pylori. Journal of Internal Medicine, 243: 251–253. doi: 10.1046/j.1365-2796.1998.00272.x
Publication History
- Issue published online: 9 OCT 2008
- Article first published online: 9 OCT 2008
- Abstract
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Keywords:
- clarithromycin;
- Clostridium difficile;
- colitis;
- diarrhoea;
- duodenal ulcer;
- Heliobacter pylori eradication therapy ;
- metronidazole;
- Saccharomyces boulardii;
- ultra-levure
Archimandritis A, Souyioultzis S, Katsorida M, Tzivras M (University of Athens Medical School, Laiko General Hospital, Athens, Greece). Clostridium difficile colitis associated with a ‘triple’ regimen, containing clarithromycin and metronidazole, to eradicate Helicobacter pylori (Case Report). J Intern Med 1998; 243: 251–53.
We describe a 54-year-old man with Helicobacter pylori (+) duodenal ulcer who developed Clostridium difficile associated colitis, 5 days after commencing a ‘triple’ regimen consisting of omeprazole 20 mg b.d., metronidazole 500 mg b.d. and clarithromycin 500 mg b.d., to eradicate H. pylori. Despite the fact that oral metronidazole did not prevent the disease, the patient did well after treatment with oral metronidazole plus a yeast preparation (Saccharomyces bulardii). No relapse occurred.