Idiopathic oedema with increased cytokine production: a pathogenetic link?
Article first published online: 5 JAN 2002
Blackwell Science Ltd, 1997
Journal of Internal Medicine
Volume 244, Issue 2, pages 179–182, August 1998
How to Cite
Hoffmann, Fontana, Steurer and Bollinger (1998), Idiopathic oedema with increased cytokine production: a pathogenetic link?. Journal of Internal Medicine, 244: 179–182. doi: 10.1046/j.1365-2796.1998.00326.x
- Issue published online: 5 JAN 2002
- Article first published online: 5 JAN 2002
- capillary leak syndrome;
- endothelial activation
Hoffmann U, Fontana A, Steurer J, Bollinger a (University Hospital, Zurich, Switzerland). Idiopathic oedema with increased cytokine production: a pathogenetic link? (Case Report). J Intern Med 1998; 244: 179–82.
We describe four patients with idiopathic oedema and elevated cytokines. All patients shared increased serum concentrations of soluble interleukin-2 receptors (sIL-2R). In three patients tumour necrosis factor alpha (TNF-alpha), gamma interferon (IFN-gamma) and interleukin-2 (IL-2) were transiently elevated. There was no evidence for an underlying disease. Based on experimental and clinical data it is hypothesized that oedema formation in our patients is the consequence of cytokine induced alteration of endothelial cells.