Idiopathic oedema with increased cytokine production: a pathogenetic link?

Authors


MD Ulrich Hoffmann Dr Department of Internal Medicine, Angiology Division, University Hospital, CH-8O91 Zurich, Switzerland (fax: +41 1255 4510).

Abstract

Hoffmann U, Fontana A, Steurer J, Bollinger a (University Hospital, Zurich, Switzerland). Idiopathic oedema with increased cytokine production: a pathogenetic link? (Case Report). J Intern Med 1998; 244: 179–82.

We describe four patients with idiopathic oedema and elevated cytokines. All patients shared increased serum concentrations of soluble interleukin-2 receptors (sIL-2R). In three patients tumour necrosis factor alpha (TNF-alpha), gamma interferon (IFN-gamma) and interleukin-2 (IL-2) were transiently elevated. There was no evidence for an underlying disease. Based on experimental and clinical data it is hypothesized that oedema formation in our patients is the consequence of cytokine induced alteration of endothelial cells.

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