Antiplasmin correlates to arterial reactivity in a healthy population of 35-year-old men and women

Authors


Dr Jan Johansson MD PhD, Research Centre of General Medicine, Borgmästarvillan, Karolinska Hospital, S-171 76 Stockholm, Sweden (fax: +8 31 70 34; e-mail: jjo@ame.ks.se).

Abstract.

Objective.  To study whether haemostasis function variables correlate with endothelial function and other vasomotion characteristics of the brachial artery in a randomly selected healthy population of 35-year-old men and women.

Design.  Endothelial function was measured as flow mediated dilatation (FMD) of the brachial artery during reactive hyperaemia and the nonendothelial dependent dilatation after sublingual nitroglycerin (NTG) was administered. Haemostasis and fibrinolysis function were estimated by analysis of von Willebrand factor, plasminogen activator inhibitor-1, antiplasmin and fibrinogen.

Setting.  A general medicine research centre and a university hospital.

Subjects.  Randomly chosen men (= 53) and women (= 56).

Results.  Univariate correlation analysis showed significant correlations between haemostasis factors, conventional risk factors for cardio- vascular disease and indices of vasomotion of the brachial artery. In multivariate analysis, with haemostasis variables and conventional risk factors included, antiplasmin was the strongest explanatory variable for FMD. When antiplasmin was removed from the analysis, the r-value dropped from 0.46 to 0.35. Antiplasmin also correlated with NTG-induced dilatation (positively) and brachial diameter at rest (negatively), albeit less consistently.

Conclusions.  Antiplasmin correlates significantly and independently to FMD, reflecting endothelial function, and also to brachial artery diameter at rest and nitroglycerin-induced dilatation. In multivariate analysis these correlations of antiplasmin to arterial characteristics were stronger than for ‘conventional’ risk factors, such as smoking, blood pressure and serum cholesterol.

Ancillary