Chronic fatigue syndrome: new insights and old ignorance
Article first published online: 25 DEC 2001
Journal of Internal Medicine
Volume 246, Issue 5, pages 455–469, November 1999
How to Cite
Evengård, B., Schacterle, R. S. and Komaroff , A. L. (1999), Chronic fatigue syndrome: new insights and old ignorance. Journal of Internal Medicine, 246: 455–469. doi: 10.1046/j.1365-2796.1999.00513.x
- Issue published online: 25 DEC 2001
- Article first published online: 25 DEC 2001
- central nervous system;
- chronic fatigue syndrome;
- hypothalamic dysfunction;
Abstract. Evengård B, Schacterle RS, Komaroff AL (Karolinska Institute at Huddinge University Hospital, Huddinge, Sweden; and Brigham and Women’s Hospital, Harvard Medical School, Boston, USA). Chronic fatigue syndrome: new insights and old ignorance. J Intern Med 1999; 246: 455–469.
Chronic fatigue syndrome (CFS) is a condition characterized by impairment of neurocognitive functions and quality of sleep and of somatic symptoms such as recurrent sore throat, muscle aches, arthralgias, headache, and postexertional malaise. A majority of patients describe an infectious onset but the link between infections and CFS remains uncertain. Findings show an activation of the immune system, abberations in several hypothalamic-pituitary axes and involvement of other parts of the central nervous system. The origin is bound to be complex and it may well be that the solution will come together with a more generally altered view about mind–body dualism, and the concept of illness and disease.