Oestrogen receptors – an overview
Article first published online: 25 DEC 2001
Journal of Internal Medicine
Volume 246, Issue 2, pages 133–138, August 1999
How to Cite
Enmark, E. and Gustafsson, J.-Å. (1999), Oestrogen receptors – an overview. Journal of Internal Medicine, 246: 133–138. doi: 10.1046/j.1365-2796.1999.00545.x
- Issue published online: 25 DEC 2001
- Article first published online: 25 DEC 2001
- nuclear receptor;
- oestrogen receptor
Enmark E, Gustafsson J-A (Karolinska Institutet, Huddinge, Sweden). Oestrogen receptors – an overview (Review). J Intern Med 1999; 246: 133–138.
The oestrogen receptor (ER) is a ligand-activated transcription factor that mediates the effects of the steroid hormone 17β-oestradiol in both males and females. Since the isolation and cloning of ER, the prevailing opinion has been that only one such receptor exists. The finding of a second subtype of ER (ERβ) has caused considerable excitement and has forced endocrinologists to re-evaluate many aspects of the actions of oestrogens. In this article, we will try to summarize the current knowledge about the two oestrogen receptor subtypes, with the emphasis on oestrogen receptor β (ERβ), and to comment on the observations in mice lacking either receptor or the hormone itself.