Infections as a major preventable cause of human cancer

Authors

  • H. Kuper,

    1. From the Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA;
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  • H.-O. Adami,

    1. From the Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA;
    2. Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden; and
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  • D. Trichopoulos

    1. From the Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA;
    2. Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden; and
    3. Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
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Hans-Olov Adami, Department of Medical Epidemiology, Karolinska Institute, PO Box 281, 171 77 Stockholm, Sweden (fax: +46 8 314 957; e-mail: Hans-olov.Adami@mep.ki.se).

Abstract

Abstract. Kuper H, Adami H-O & Trichopoulos D (Harvard School of Public Health, Boston, MA, USA; Karolinska Institute, Stockholm, Sweden; University of Athens Medical School, Greece). Infections as a major preventable cause of human cancer (Internal Medicine in the 21st Century). J Intern Med 2000; 248: 171–183.

Infections may be responsible for over 15% of all malignancies worldwide. Important mechanisms by which infectious agents may induce carcinogenesis include the production of chronic inflammation, the transformation of cells by insertion of oncogenes and inhibition of tumour suppressors, and the induction of immunosuppression. Common characteristics shared by infectious agents linked to malignancies are that they are persistent in the host, often highly prevalent in the host population and induce cancer after a long latency. The associations between a selection of infectious agents and malignancies are covered in detail.

Ancillary