Infections as a major preventable cause of human cancer
Article first published online: 20 DEC 2001
Journal of Internal Medicine
Volume 249, Issue S741, pages 61–74, February 2001
How to Cite
Kuper, H., Adami, H.-O. and Trichopoulos, D. (2001), Infections as a major preventable cause of human cancer. Journal of Internal Medicine, 249: 61–74. doi: 10.1046/j.1365-2796.2001.00742.x
- Issue published online: 20 DEC 2001
- Article first published online: 20 DEC 2001
- public health
Abstract. Kuper H, Adami H-O & Trichopoulos D (Harvard School of Public Health, Boston, MA, USA; Karolinska Institute, Stockholm, Sweden; University of Athens Medical School, Greece). Infections as a major preventable cause of human cancer (Internal Medicine in the 21st Century). J Intern Med 2000; 248: 171–183.
Infections may be responsible for over 15% of all malignancies worldwide. Important mechanisms by which infectious agents may induce carcinogenesis include the production of chronic inflammation, the transformation of cells by insertion of oncogenes and inhibition of tumour suppressors, and the induction of immunosuppression. Common characteristics shared by infectious agents linked to malignancies are that they are persistent in the host, often highly prevalent in the host population and induce cancer after a long latency. The associations between a selection of infectious agents and malignancies are covered in detail.