Adulteration of Chinese herbal medicines with synthetic drugs: a systematic review
Article first published online: 20 AUG 2002
Journal of Internal Medicine
Volume 252, Issue 2, pages 107–113, August 2002
How to Cite
Ernst, E. (2002), Adulteration of Chinese herbal medicines with synthetic drugs: a systematic review. Journal of Internal Medicine, 252: 107–113. doi: 10.1046/j.1365-2796.2002.00999.x
- Issue published online: 20 AUG 2002
- Article first published online: 20 AUG 2002
- Chinese medicine;
- complementary and alternative medicine;
- herbal medicine;
Abstract. Ernst E. (University of Exeter, Exeter, UK). Adulteration of Chinese herbal medicines with synthetic drugs: a systematic review (Review Article). J Intern Med 2002; 252: 107–113.
The popularity of Chinese herbal medicines (CHMs) demands a critical analysis of safety issues. The aim of this systematic review is to summarize data regarding adulterations of CHMs with conventional drugs. Literature searches were carried out in six databases. Articles containing original data on adulterations were considered without language restrictions. Eighteen case reports, two case series and four analytical investigations were identified. The list of adulterants contains drugs associated with serious adverse effects like corticosteroids. In several instances, patients were seriously harmed. One report from Taiwan suggests that 24% of all samples were contaminated with at least one conventional pharmacological compound. It is concluded that adulteration of CHMs with synthetic drugs is a potentially serious problem which needs to be addressed by adequate regulatory measures.