Decreased muscle strength and contents of Mg and Na,K-pumps in chronic alcoholics occur independently of liver cirrhosis
Article first published online: 26 FEB 2003
Journal of Internal Medicine
Volume 253, Issue 3, pages 359–366, March 2003
How to Cite
Aagaard, N. K., Andersen, H., Vilstrup, H., Clausen, T., Jakobsen, J. and Dørup, I. (2003), Decreased muscle strength and contents of Mg and Na,K-pumps in chronic alcoholics occur independently of liver cirrhosis. Journal of Internal Medicine, 253: 359–366. doi: 10.1046/j.1365-2796.2003.01100.x
- Issue published online: 26 FEB 2003
- Article first published online: 26 FEB 2003
- Received 16 July 2002; revision received 11 November 2002; accepted 26 November 2002
- chronic alcoholism;
- liver cirrhosis;
- muscle magnesium;
- muscle strength;
Abstract. Aagaard NK, Andersen H, Vilstrup H, Clausen T, Jakobsen J, Dørup I (Aarhus University Hospital; and University of Aarhus, Aarhus, Denmark). Decreased muscle strength and contents of Mg and Na,K-pumps in chronic alcoholics occur independently of liver cirrhosis. J Intern Med 2003; 253: 359–366.
Objectives. To evaluate the influence of established liver cirrhosis on muscle strength and muscle contents of magnesium (Mg), potassium (K) and sodium, potassium pumps (Na,K-pumps) in chronic alcoholic patients.
Design. An open cross-sectional study.
Setting and subjects. Forty consecutive chronic alcoholics (18 with cirrhosis and 22 without cirrhosis) admitted to the Department of Hepatology, Aarhus University Hospital, Denmark, or to a collaborating alcoholism treatment centre, and 36 healthy control subjects.
Main outcome measures. Evaluation of participant's subjective physical ability and measurement of maximum isokinetic muscle strength and muscle mass, as well as measurements of Mg, K and Na,K-pumps in skeletal muscle.
Results. Maximum isokinetic muscle strength and muscle mass were equally reduced in patients with and without cirrhosis (P < 0.01 all). In keeping with this, both groups of patients felt equally physically restricted. Muscle Mg was reduced to the same extent in the two groups of patients (by 12 and 9%, P < 0.001, both), whereas the muscle K content was only significantly lower in the cirrhotic patients (10%, P < 0.001). The muscle content of Na,K-pumps was reduced by 14%, (P < 0.01) in the cirrhotic patients and by 8% (P < 0.05) in the noncirrhotic patients.
Conclusion. Our alcoholic patients complained of physical disability, had reduced skeletal muscle mass, isokinetic muscle strength, content of muscle Mg and content of Na,K-pumps. There was no difference between patients with and without cirrhosis. It appears that it is the heavy alcohol intake, and not the cirrhosis per se, that is responsible for the observed defects.