You have full text access to this OnlineOpen article

Smoking and relation to other risk factors in postmenopausal women with coronary artery disease, with particular reference to whole blood viscosity and β-cell function

  1. I. Os1,2,
  2. A. Høieggen2,
  3. A. Larsen3,
  4. P. M. Sandset4,
  5. S. Djurovic5,
  6. K. Berg5,
  7. A. Os6,
  8. K. Birkeland7,
  9. A. Westheim3

Article first published online: 24 JAN 2003

DOI: 10.1046/j.1365-2796.2003.01110.x

Issue

Journal of Internal Medicine

Journal of Internal Medicine

Volume 253, Issue 2, pages 232–239, February 2003

Additional Information

How to Cite

Os, I., Høieggen, A., Larsen, A., Sandset, P. M., Djurovic, S., Berg, K., Os, A., Birkeland, K. and Westheim, A. (2003), Smoking and relation to other risk factors in postmenopausal women with coronary artery disease, with particular reference to whole blood viscosity and β-cell function. Journal of Internal Medicine, 253: 232–239. doi: 10.1046/j.1365-2796.2003.01110.x

Author Information

  1. 1

    From the Department of Pharmacotherapeutics, University of Oslo; Departments of

  2. 2

    Nephrology,

  3. 3

    Cardiology,

  4. 4

    Haematology,

  5. 5

    Genetics,

  6. 6

    Research Forum, Ulleval University Hospital and

  7. 7

    Department of Endocrinology, Aker University Hospital, Oslo, Norway

Publication History

  1. Issue published online: 24 JAN 2003
  2. Article first published online: 24 JAN 2003

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (102K)

Keywords:

  • age;
  • β-cell function;
  • coronary artery disease;
  • oestrone;
  • smoking;
  • whole blood viscosity;
  • women

Abstract.  Os I, Høieggen A, Larsen A, Sandset PM, Djurovic S, Berg K, Os A, Birkeland K, Westheim A (University of Oslo; Ulleval University Hospital; and Aker University Hospital, Oslo, Norway). Smoking and relation to other risk factors in postmenopausal women with coronary artery disease, with particular reference to whole blood viscosity and β-cell function. J Intern Med 2003; 253: 232–239.

Objectives.  To investigate possible associations between smoking habits and other coronary risk factors in postmenopausal women with known coronary heart disease (CHD).

Setting.  The study was conducted at a university clinic.

Subjects.  A total of 118 postmenopausal women with CHD verified with angiography, consecutively recruited.

Interventions.  Conventional treatment for CHD. The women were randomized to hormone replacement therapy (HRT) with transdermal 17-β oestradiol and medroxyprogesterone acetate, or to a control group.

Results.  Smokers were younger (P = 0.005), had lower body mass index (P = 0.04) and lipoprotein Lp(a) levels (P = 0.02) compared with nonsmokers. Smokers had reduced β-cell function (homeostasis model assessment, P = 0.006), whereas whole blood viscosity (WBV) was higher at all shear rates. WBV was not affected by HRT over a 12-month period. Oestrone levels were higher in smokers.

Conclusions.  Smoking adversely affects insulin secretion (β-cell function) and WBV in postmenopausal women with established CHD, which could be of importance as a mechanism for the increased risk of CHD in smokers. The importance of smoking as a risk factor, overrides the effect of Lp(a), which is lower in smokers compared with nonsmokers.

View Full Article (HTML) Get PDF (102K)