Beneficial effect of glucose-insulin- potassium infusion in noncritically ill patients has to be proven – reply
Article first published online: 9 OCT 2003
Journal of Internal Medicine
Volume 254, Issue 5, page 514, November 2003
How to Cite
Bonnier, M., Lönnroth, P., Gudbjörnsdottir, S., Attvall, S. and Jansson, P.-A. (2003), Beneficial effect of glucose-insulin- potassium infusion in noncritically ill patients has to be proven – reply. Journal of Internal Medicine, 254: 514. doi: 10.1046/j.1365-2796.2003.01191.x
- Issue published online: 9 OCT 2003
- Article first published online: 9 OCT 2003
- Received and accepted 18 March 2003.
We thank Dr van der Hosts and colleagues for their interest to discuss our study and agree with their concerns about the need of more studies to prove the benefits of intensified insulin therapy in this diabetic group.
Earlier studies with glucose-insulin-potassium (GIK) infusion have been amongst diabetics with severe illness and probably suffered from severe insulin resistance [1–3]. These patients in this study were both type 1 and type 2 diabetics and the indications for the infusion were all from blood glucose fluctuation in ‘healthy’ insulin sensitive type 1 diabetics to severe insulin resistance amongst infectious diabetics.
Hypoglycaemia is common in and probably the biggest limiting factor to improve diabetes control amongst type 1 diabetics . All this mild hypoglycaemia in this study was amongst type 1 diabetic patients and two of the hypoglycaemia episodes were in the same person.
The daily insulin demand was between 28 and 122 IU per day. Comparison and mean blood glucose values were calculated from measurements five times per day. The aim with this study was to validate and prove that this infusion was safe enough to handle at a normal internal medicine ward and without increasing the personal staff. Our hope is that this GIK-infusion algorithm could be a useful tool for future studies to prove the benefits of intensified insulin therapy even for this group of diabetics.
Conflict of interest statement
No conflict of interest was declared.
- 4Hypoglycaemia awareness and counter-regulation in type 1 diabetes. Int J Clin Pract 2000; 112: 33–37..