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Keywords:

  • 14-3-3;
  • pineal;
  • N-acetyltransferase;
  • signal transduction;
  • melatonin;
  • serotonin

Abstract

Recent studies suggest that a common theme links the diverse elements of pineal photoneuroendocrine transduction –regulation via binding to 14-3-3 proteins. The elements include photoreception, neurotransmission, signal transduction and the synthesis of melatonin from tryptophan. We review general aspects of 14-3-3 proteins and their biological function as binding partners, and also focus on their roles in pineal photoneuroendocrine transduction.