• 1
    Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse ob gene and its human homologue. Nature 1994; 372 : 425432.
  • 2
    Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM, Hughes IA, McCamish MA, O'Rahilly S. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999; 341 : 879884.
  • 3
    Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature 1996; 382 : 250252.
  • 4
    Flier JS. What's in a name? In search of leptin's physiological role. J Clin Endocrinol Metab 1998; 83 : 14071413.
  • 5
    Flier JS, Harris M, Hollenberg AN. Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring. J Clin Invest 2000; 105 : 859861.
  • 6
    Kim MS, Small CJ, Stanley SA, Morgan DGA, Seal LJ, Kong WM, Edwards CM, Abusnana S, Sunter D, Shatei MA, Bloom SR. The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. J Clin Invest 2000; 105 : 11051011.
  • 7
    Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS. A transgenic model of visceral obesity and the metabolic syndrome. Science 2001; 294 : 21662170.
  • 8
    Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazer MA. The hormone resistin links obesity to diabetes. Nature 2001; 409 : 292293.
  • 9
    Wang H, Chu WS, Hemphill C, Elbein SC. Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians. J Clin Endocrinol Metab 2002; 87 : 25202524.
  • 10
    Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kegechika H, Shudo K, Yoda M, Nakano Y, Tobe M, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Med 2001; 7 : 941946.
  • 11
    Combs TP, Berg AH, Obici S, Scherer PE, Rossetti L. Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J Clin Invest 2001; 108 : 18751881.
  • 12
    Karlsson C, Lindell K, Ottosson M, Sjöström L, Carlsson B, Carlsson LMS. Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II. J Clin Endocrinol Metab 1998; 83 : 39253929.
  • 13
    Ahima RS, Flier JS. Adipose tissue as an endocrine organ. Trends Endocrin Met 2000; 11 : 327332.
  • 14
    Bartness TJ, Bamshad M. Innervation of mammalian white adipose tissue: implications for the regulation of total body fat. Am J Physiol 1998; 275 : R1399R1411.
  • 15
    Getty LG, Panteleon AE, Mittelman SD, Dea MK, Bergman RN. Rapid oscillations in omental lipolysis are independent of changing insulin levels in vivo. J Clin Invest 2000; 106 : 421430.
  • 16
    Dodt C, Lönnroth P, Fehm HL, Elam M. The subcutaneous lipolytic response to regional neural stimulation is reduced in obese women. Diabetes 2000; 49 : 18751879.
  • 17
    Migliorini RH, Garofalo MAR, Kettelhut IC. Increased sympathetic activity in rat white adipose tissue during prolonged fasting. Am J Physiol 1997; 272 : R656R661.
  • 18
    Patel JN, Coppack SW, Goldstein DS, Miles JM, Eisenhofer G. Norepinephrine spillover from human adipose tissue before and after a 72-hour fast. J Clin Endicrinol Metab 2002; 87 : 33733377.
  • 19
    Bamshad M, Aoki VT, Adkison MG, Warren WS, Bartness TJ. Central nervous system origins of the sympathetic nervous system outflow to white adipose tissue. Am J Physiol 1998; 275 : R291R299.
  • 20
    Buijs RM, Kalsbeek A. Hypothalamic integration of central and peripheral clocks. Nature Rev Neurosci 2001; 2 : 521526.
  • 21
    Kalsbeek A, Fliers E, Romijn JA, La Fleur SE, Wortel J, Bakker O, Endert E, Buijs RM. The suprachiasmatic nucleus generates the diurnal changes in plasma leptin levels. Endocrinology 2001; 142 : 26772685.
  • 22
    Kreier F, Fliers E, Voshol PJ, Van Eden CG, Havekes LM, Kalsbeek A, Van Heijningen CL, Sluiter AA, Mettenleiter TC, Romijn JA, Sauerwein HP, Buijs RM. Selective parasympathetic innervation of subcutaneous and intra-abdominal fat; functional implications. J Clin Invest 2002; 110 : 12431250.
  • 23
    Yanovski JA, Miller KD, Kino T, Friedman TC, Chrousos GP, Tsigos C, Falloon J. Endocrine and metabolic evaluation of human immunodeficiency virus-infected patients with evidence of protease inhibitor-asociated lipodystrophy. J Clin Endocrinol Metab 1999; 84 : 19251931.
  • 24
    Lo JC, Mulligan K, Tai VW, Algren H, Schambelan M. ‘Buffalo hump’ in men with HIV infection. Lancet 1999; 351 : 867870.
  • 25
    Wynn HE, Brundage RC, Fletcher CV. Clinical implications of CNS penetration of antiretroviral drugs. CNS Drugs 2002; 16 : 595609.
  • 26
    Fliers E, Sauerwein HP, Romijn JA, Reiss P, Van der Valk M, Kalsbeek A, Kreier F, Buijs RM. HIV-associated adipose redistribution syndrome is a selective neuropathy. Lancet 2003, in press.
  • 27
    Van der Valk M, Reiss P, Van Leth FC, Ackermans M, Endert E, Romijn JA, Heijligenberg R, Sauerwein HP. HAART induced lipolysis has minor effects on HIV induced changes in lipolysis but normalizes resting energy expenditure. J Clin Endocrinol Metab 2002; 87 : 50665071.