This paper was presented at the 11th Annual American College of Veterinary Surgeons Veterinary Symposium, Chicago, IL, USA, October 11–14, 2001.
Disposition of cyclosporine after intravenous and multi-dose oral administration in cats
Article first published online: 20 OCT 2003
Journal of Veterinary Pharmacology and Therapeutics
Volume 26, Issue 5, pages 349–354, October 2003
How to Cite
Mehl, M. L., Kyles, A. E., Craigmill, A. L., Epstein, S. and Gregory, C. R. (2003), Disposition of cyclosporine after intravenous and multi-dose oral administration in cats. Journal of Veterinary Pharmacology and Therapeutics, 26: 349–354. doi: 10.1046/j.1365-2885.2003.00496.x
- Issue published online: 20 OCT 2003
- Article first published online: 20 OCT 2003
- (Paper received 13 January 2003; accepted for publication 1 May 2003)
The aim of this study was to evaluate the disposition of cyclosporine after intravenous (i.v.) and oral administration and to evaluate single sampling times for therapeutic monitoring of cyclosporine drug concentrations in cats. Six adult male cats (clinically intact) were used. Two treatments consisting of a single i.v. cyclosporine (1 mg/kg) and multiple oral cyclosporine (3 mg/kg b.i.d p.o. for 2 weeks) doses. Whole blood cyclosporine concentrations were measured at fixed times by high performance liquid chromatography and pharmacokinetic values were calculated. Mean values for the i.v. data included AUC (7413 ng/mL·h), t1/2 distribution and elimination (0.705 and 9.7 h, respectively), Cmax (1513 ng/mL), and Vd(ss) (1.71 L/kg). Mean values for the oral data included AUC (6243 ng/mL·h), t1/2 of absorption and elimination (0.227 and 8.19 h, respectively), and Cmax (480.0 ng/mL). Bioavailability of orally administered cyclosporine was 29 and 25% on days 7 and 14 respectively. Whole blood comment cyclosporine concentration 2 h after administration (C2) better correlated with AUC on days 7 and 14 than trough plasma concentration (C12). The rate of oral cyclosporine absorption was less than expected and there was substantial individual variation. Therapeutic drug monitoring strategies for cyclosporine in cats should be re-evaluated.