Hepatitis B third-generation vaccines: improved response and conventional vaccine non-response – third generation pre-S/S vaccines overcome non-response
Article first published online: 28 FEB 2002
1998 Blackwell Science Ltd
Journal of Viral Hepatitis
Volume 5, Issue Supplement s2, pages 13–15, November 1998
How to Cite
Zuckerman, J. N. (1998), Hepatitis B third-generation vaccines: improved response and conventional vaccine non-response – third generation pre-S/S vaccines overcome non-response. Journal of Viral Hepatitis, 5: 13–15. doi: 10.1046/j.1365-2893.1998.0050s2013.x
- Issue published online: 28 FEB 2002
- Article first published online: 28 FEB 2002
- Cited By
- hepatitis B;
- surface antigen;
- immune response;
- triple-S hepatitis B vaccine.
A new triple-S containing recombinant hepatitis B vaccine was evaluated in terms of immunogenicity and reactogenicity in a cohort of healthy healthcare professionals who were persistent non-responders to the currently licensed hepatitis B vaccines. One hundred subjects were allocated randomly to receive two doses of 5, 10, 20 or 40 μg of a new hepatitis B vaccine 2 months apart. The overall seroconversion rate was 70% with a single dose of 20 μg of the vaccine being as effective as two doses of either 20 μg or 40 μg of the vaccine formulation in terms of seroconversion, seroprotection and geometric mean titres.