Does hepatitis B virus (HBV) genotype influence the clinical outcome of HBV infection?
Article first published online: 28 FEB 2002
1999 Blackwell Science Ltd
Journal of Viral Hepatitis
Volume 6, Issue 4, pages 299–304, July 1999
How to Cite
Mayerat, C., Mantegani, A. and Frei, P. C. (1999), Does hepatitis B virus (HBV) genotype influence the clinical outcome of HBV infection?. Journal of Viral Hepatitis, 6: 299–304. doi: 10.1046/j.1365-2893.1999.00174.x
- Issue published online: 28 FEB 2002
- Article first published online: 28 FEB 2002
- Cited By
- acute hepatitis;
- chronic active hepatitis;
- gene length polymorphism;
- hepatitis B;
Between 5 and 10% of adults infected with the hepatitis B virus (HBV) develop a chronic infection lasting longer than 6 months, which may lead to advanced liver disease. HBV can be classified into six genotypic families: A, B, C, D, E and F, but only genotypes A and D are significantly represented in western Europe, where they account for some 90% of cases of infection with HBV. In the present study, we investigated a possible association between HBV genotype A or D and clinical outcome of the infection. We compared the prevalence of these genotypes in a group of patients with chronic active hepatitis to that of a group with acute resolving hepatitis. In patients with chronic active hepatitis, genotype A was found in 28 of 35 patients and genotype D in only four. The remaining three patients were infected with genotype non-A, non-D. In contrast, genotype D was found in 24 of 30 patients with acute hepatitis, whilst genotype A was found in only three patients of this group. Three were infected with genotype non-A, non-D. Our results show a clear association between genotype A and chronic outcome (Ficher’s exact test: two-sided P-value, P < 0.0001). They suggest that HBV genotypes may play a role in the virus–host relationship. Possible mechanisms for such a role are discussed.