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Secondary structures and starvation-induced frameshifting
Article first published online: 31 OCT 2003
DOI: 10.1046/j.1365-2958.1997.6101959.x
Blackwell Science Ltd, Oxford
1365-2958/asset/cover.gif?v=1&s=75254d9e3ae6a0f08085f34cc6e5bd65d8e3d52e "Molecular Microbiology")
Additional Information
How to Cite
Atkinson, J., Dodge, M. and Gallant, J. (1997), Secondary structures and starvation-induced frameshifting. Molecular Microbiology, 26: 747–753. doi: 10.1046/j.1365-2958.1997.6101959.x
Publication History
- Issue published online: 31 OCT 2003
- Article first published online: 31 OCT 2003
- Abstract
- Cited By
We have examined the effect of a downstream secondary structure (the stem–loop sequence found downstream on the MMTV gag-pro frameshift site) on frameshifting at a bacterial shifty site (U UUC AUA) that responds strongly to a isoleucine-tRNA limitation. Our findings are as follows: (i) the downstream stem–loop has little effect on frameshifting in growing, unstarved cells; (ii) the stem–loop increases the frameshifting effect of isoleucine-tRNA limitation about fourfold, and this synergism is maximal with a distance of 5–9 nucleotides between the ‘hungry’ AUA codon and the stem–loop; and (iii) a stem–loop of different sequence at the same position has the same effect.