• 1
    Apodaca, G., Bomsel, M., Lindstedt, R., Engel, J., Frank, D., Mostov, K.E., Wiener-Kronish, J. (1995) Characterization of Pseudomonas aeruginosa-induced MDCK cell injury: glycosylation-defective host cells are resistant to bacterial killing. Infect Immun 63: 15411551.
  • 2
    Bolin, I. & Wolf-Watz, H. (1988) The plasmid-encoded Yop2b protein of Yersinia pseudotuberculosis is a virulence determinant regulated by calcium and temperature at the level of transcription. Mol Microbiol 2: 237245.
  • 3
    Chen, L.M., Hobbie, S., Galán, J.E. (1996a) Requirement of CDC42 for Salmonella typhimurium-induced cytoskeletal reorganization and nuclear responses in cultured cell. Science 274: 21152118.
  • 4
    Chen, L.M., Kaniga, K., Galán, J.E. (1996b) Salmonella spp. are cytotoxic for cultured macrophages. Mol Microbiol 21: 11011115.
  • 5
    Collazo, C. & Galán, J.E. (1996) Requirement of exported proteins for secretion through the invasion-associated type III system in Salmonella typhimurium. Infect Immun 64: 35243531.
  • 6
    Collazo, C. & Galán, J.E. (1997) The invasion-associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cell. Mol Microbiol 24: 747756.
  • 7
    Collazo, C.M., Zierler, M.K., Galán, J.E. (1995) Functional analysis of the Salmonella typhimurium invasion genes invI and invJ and identification of a target of the protein secretion apparatus encoded in the inv locus. Mol Microbiol 15: 2538.
  • 8
    Finlay, B.B. & Ruschkowski, S. (1991) Cytoskeletal rearrangements accompanying Salmonella entry into epithelial cells. J Cell Sci 99: 283296.
  • 9
    Forsberg, A. & Wolf-Watz, H. (1990) Genetic analysis of the yopE region of Yersinia spp.: identification of a novel conserved locus, yerA, regulating yopE expression. J Bacteriol 172: 15471555.
  • 10
    Galán, J.E. (1996) Molecular bases of Salmonella entry into host cells. Mol Microbiol 20: 263271.
  • 11
    Galán, J.E. & Bliska, J.B. (1996) Cross-talk between bacterial pathogens and their host cells. Annu Rev Cell Dev Biol 12: 219253.
  • 12
    Galán, J.E. & Curtiss, III, R. (1990) Expression of Salmonella typhimurium genes required for invasion is regulated by changes in DNA supercoiling. Infect Immun 58: 18791885.
  • 13
    Galán, J.E., Ginocchio, C., Costeas, P. (1992) Molecular and functional characterization of the Salmonella typhimurium invasion gene invA : homology of InvA to members of a new protein family. J Bacteriol 17: 43384349.
  • 14
    Ginocchio, C., Pace, J., Galán, J.E. (1992) Identification and molecular characterization of a Salmonella typhimurium gene involved in triggering the internalization of salmonellae into cultured epithelial cells. Proc Natl Acad Sci USA 89: 59765980.
  • 15
    Guan, K.-L. & Dixon, J.E. (1991) Eukaryotic proteins expressed in Escherichia coli : an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal Biochem 192: 262267.
  • 16
    Hardt, W.-D. & Galán, J.E. (1997) A secreted Salmonella protein with homology to an avirulence determinant of plant pathogenic bacteria. Proc Natl Acad Sci USA 94: 98879892.
  • 17
    Hoiseth, S.K. & Stocker, B.A. (1981) Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature 291: 238239.
  • 18
    Hueck, C.J., Hantman, M.J., Bajaj, V., Johnston, C., Lee, C.A., Miller, S.I. (1995) Salmonella typhimurium secreted invasion determinants are homologous to Shigella Ipa proteins. Mol Microbiol 18: 479490.
  • 19
    Kaniga, K., Trollinger, D., Galán, J.E. (1995a) Identification of two targets of the type III secretion system encoded in the inv and spa loci of Salmonella typhimurium that share homology to IpaD and IpaA proteins. J Bacteriol 177: 70787085.
  • 20
    Kaniga, K., Tucker, S.C., Trollinger, D., Galán, J.E. (1995b) Homologues of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells. J Bacteriol 177: 39653971.
  • 21
    Kaniga, K., Uralil, J., Bliska, J.B., Galán, J.E. (1996) A secreted tyrosine phosphatase with modular effector domains encoded by the bacterial pathogen Salmonella typhimurium. Mol Microbiol 21: 633641.
  • 22
    Kulich, S.M., Yahr, T.L., Mende-Mueller, L.M., Barbieri, J.T., Frank, D.W. (1994) Cloning the structural gene for the 49-kDa form of exoenzyme S (exoS) from Pseudomonas aeruginosa strain 38. Biol Chem 269: 1043110437.
  • 23
    Michiels, T. & Cornelis, G. (1988) Nucleotide sequence and transcription analysis of yop51 from Yersinia enterocolitica W22703. Microb Pathog 5: 449459.
  • 24
    Michiels, T., Wattiau, P., Brasseur, R., Ruysschaert, J.M., Cornelis, G. (1990) Secretion of Yop proteins by Yersiniae. Infect Immun 58: 28402849.
  • 25
    Nobes, C.D. & Hall, A. (1995) Rho, Rac and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellopodia, and filopodia. Cell 81: 5362.
  • 26
    Persson, C., Nordfelth, R., Holmström, A., Hakansson, S., Rosqvist, R., Wolf-Watz, H. (1995) Cell surface-bound Yersinia translocate the protein tyrosine phosphatase YopH by a polarized mechanism into the target cell. Mol Microbiol 18: 135150.
  • 27
    Ridley, A.J. & Hall, A. (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70: 389399.
  • 28
    Rosqvist, R., Forsberg, A., Wolf, W.H. (1991) Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption. Infect Immun 59: 45624569.
  • 29
    Rosqvist, R., Magnusson, K.E., Wolf-Watz, H. (1994) Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells. EMBO J 13: 964972.
  • 30
    Sory, M.-P. & Cornelis, G.R. (1994) Translocation of a hybrid YopE–adenylate cyclase from Yersinia enterocolitica into HeLa cells. Mol Microbiol 14: 583594.
  • 31
    Wood, M.H., Rosqvist, R., Mullan, P.B., Edwards, M.H., Galyov, E.E. (1996) SopE, a secreted protein of Salmonella dublin, is translocated into the target eukaryotic cell via a sip-dependent mechanism and promotes bacterial entry. Mol Microbiol 22: 327338.
  • 32
    Yahr, T.L., Goranson, J., Frank, D.W. (1996) Exoenzyme S of Pseudomonas aeruginosa is secreted by a type III pathway. Mol Microbiol 22: 9911003.