• 1
    Appelmelk, B.J., An, Y.-Q., Hekker, T.A.M., Thijs, L.G., MacLaren, D.M., De Graaf, J. (1994) Frequencies of lipopolysaccharide core types in Escherichia coli strains from bacteraemic patients. Microbiology 140: 11191124.
  • 2
    Bauer, M.E. & Welch, R.A. (1997) Pleiotropic effects of a mutation in rfaC on Escherichia coli hemolysin. Infect Immun 65: 22182224.
  • 3
    Belunis, C.J. & Raetz, C.R.H. (1992) Biosynthesis of endotoxins: purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli. J Biol Chem 267: 99889997.
  • 4
    Brade, L., Grimmecke, H.-D., Holst, O., Brabetz, W., Zamojski, A., Brade, H. (1996) Specificity of monoclonal antibodies against Escherichia coli K-12 lipopolysaccharide. J Endotox Res 3: 3947.
  • 5
    Di Padova, F.E., Brade, H., Barclay, G.R., Poxton, I.R., Liehl, E., Schuetze, E., et al (1993) A broadly cross-protective monoclonal antibody binding to Escherichia coli and Salmonella lipopolysaccharides. Infect Immun 61: 38633872.
  • 6
    Gamian, A., Romanowska, E., Ulrich, J., Defaye, J. (1992) The structure of the sialic acid-containing Escherichia coli O104 O-specific polysaccharide and its linkage to the core region in lipopolysaccharide. Carbohydr Res 236: 195208.
  • 7
    Geremia, R.A., Petroni, E.A., Ielpi, L., Henrissat, B. (1996) Towards a classification of glycosyltransferases based on amino acid sequence similarities: prokaryotic α-mannosyltransferases. Biochem J 318: 133138.
  • 8
    Gibb, A.P., Barclay, G.R., Poxton, I.R., Di Padova, F. (1992) Frequencies of lipopolysaccharide core types among clinical isolates of Escherichia coli defined with monoclonal antibodies. J Infect Dis 166: 10511057.
  • 9
    Hammond, S.M., Lambert, P.A., Rycroft, A.N. (1984) The cell envelope in bacterial disease. In The Bacterial Cell Surface. Hammond, S.M., Lambert, P.A. and Rycroft, A.N. (eds). Washington, DC: Kapitan Szabo, pp. 147193.
  • 10
    Hasin, M. & Kennedy, E.P. (1982) Role of phosphatidylethanolamine in the biosynthesis of pyrophosphoethanolamine residues in the lipopolysaccharide of Escherichia coli. J Biol Chem 257: 1247512477.
  • 11
    Heinrichs, D.E., Yethon, J.A., Amor, P.A., Whitfield, C. (1998a) The assembly system for the outer core portion of R1 and R4-type lipopolysaccharides of Escherichia coli. The R1 core-specific β-glucosyltransferase provides a novel attachment site for O polysaccharides. J Biol Chem (in press).
  • 12
    Heinrichs, D.E., Monteiro, M.A., Perry, M.B., Whitfield, C. (1998b) The assembly system for the lipopolysaccharide R2 core-type of Escherichia coli is a hybrid of those found in Escherichia coli K-12 and Salmonella enterica. Structure and function of WaaK and WaaL homologs. J Biol Chem 273: 88498859.
  • 13
    Holst, O. & Brade, H. (1992) Chemical structure of the core region of lipopolysaccharides. In Bacterial Endotoxic Lipopolysaccharides. Morrison, D.C. and Ryan, J.L. (eds). Boca Raton, FL: CRC Press, pp. 134170.
  • 14
    Jacques, M. (1996) Role of lipo-oligosaccharides and lipopolysaccharides in bacterial adherence. Trends Microbiol 4: 408410.
  • 15
    Kadrmas, J.L. & Raetz, C.R.H. (1998) Enzymatic properties of lipopolysaccharide in Escherichia coli. Purification and properties of heptosyltransferase I. J Biol Chem 273: 27992807.
  • 16
    Klena, J.D., Ashford, R.S., II, Schnaitman, C.A. (1992) Role of Escherichia coli K-12 rfa genes and the rfp gene of Shigella dysenteriae 1 in generation of lipopolysaccharide core heterogeneity and attachment of O antigen. J Bacteriol 174: 72977307.
  • 17
    MacLachlan, P.R., Kadam, S.K., Sanderson, K.E. (1991) Cloning, characterization, and DNA sequence of the rfaLK region for lipopolysaccharide synthesis in Salmonella typhimurium LT2. J Bacteriol 173: 71517163.
  • 18
    Mäkelä, P.H. & Stocker, B.A.D. (1984) Genetics of lipopolysaccharide. In Handbook of Endotoxin. Rietschel, E.T. (ed.). Amsterdam: Elsevier Science Publishers, pp. 59137.
  • 19
    Marolda, C.L. & Valvano, M.A. (1998) The promoter region of the Escherichia coli O7-specific lipopolysaccharide gene cluster: Structural and functional characterization of an upstream untranslated mRNA sequence. J Bacteriol 180: 30703079.
  • 20
    Olsthoorn, M.M.A., Petersen, B.O., Schlecht, S., Haverkamp, J., Bock, K., Thomas-Oates, J.E., Holst, O. (1998) Identification of a novel core type in Salmonella lipopolysaccharide. Complete structural analysis of the core region of the lipopolysaccharide from Salmonella enterica sv. Arizonae O62. J Biol Chem 273: 38173829.
  • 21
    Parker, C.T., Kloser, A.W., Schnaitman, C.A., Stein, M.A., Gottesman, S., Gibson, B.W. (1992) Role of the rfaG and rfaP genes in determining the lipopolysaccharide core structure and cell surface properties of Escherichia coli K-12. J Bacteriol 174: 25252538.
  • 22
    Polissi, A. & Georgopoulos, C. (1996) Mutational analysis and properties of the msbA gene of Escherichia coli, coding for an essential ABC family transporter. Mol Microbiol 20: 12211233.
  • 23
    Raetz, C.R.H. (1996) Bacterial lipopolysaccharides: A remarkable family of bioactive macroamphiphiles. In Escherichia coli and Salmonella. Cellular and Molecular Biology. Neidhardt, F.C., Curtiss R. III, Ingraham, J.L., Lin, E.C.C., Low, K.B., et al. (eds). Washington, DC: American Society for Microbiology Press, pp. 10351063.
  • 24
    Reeves, P.R., Hobbs, M., Valvano, M.A., Skurnik, M., Whitfield, C., Coplin, D., et al (1996) Bacterial polysaccharide synthesis and gene nomenclature. Trends Microbiol 4: 495503.
  • 25
    Schnaitman, C.A. & Klena, J.D. (1993) Genetics of lipopolysaccharide biosynthesis in enteric bacteria. Microbiol Rev 57: 655682.
  • 26
    Severn, W.B., Kelly, R.F., Richards, J.C., Whitfield, C. (1996) Structure of the core oligosaccharide in the serotype O8 lipopolysaccharide from Klebsiella pneumoniae. J Bacteriol 178: 17311741.
  • 27
    Sirisena, D.M., MacLachlan, P.R., Liu, S.-L., Hessel, A., Sanderson, K.E. (1994) Molecular analysis of the rfaD gene, for heptose synthesis, and the rfaF gene, for heptose transfer, in lipopolysaccharide synthesis in Salmonella typhimurium. J Bacteriol 176: 23792385.
  • 28
    Stanislavsky, E.S., Makarenko, T.A., Kholodkova, E.V., Lugowski, C. (1997) R-form lipopolysaccharides (LPS) of Gram-negative bacteria as possible vaccine antigens. FEMS Immunol Med Microbiol 18: 139145.
  • 29
    Stanley, P.L.D., Diaz, P., Bailey, M.J.A., Gygi, D., Juarez, A., Hughes, C. (1993) Loss of activity in the secreted form of Escherichia coli haemolysin caused by an rfaP lesion in core lipopolysaccharide assembly. Mol Microbiol 10: 781787.
  • 30
    Süsskind, M., Brade, L., Brade, H., Holst, O. (1998) Identification of a novel heptoglycan of α1 [RIGHTWARDS ARROW] 2-linked D-glycero-D-manno-heptopyranose. Chemical and antigenic structure of lipopolysaccharides from Klebsiella pneumoniae ssp. pneumoniae rough strain R20 (O1:K20). J Biol Chem 273: 70067017.
  • 31
    Whitfield, C., Amor, P.A., Köplin, R. (1997) Modulation of the surface architecture of Gram-negative bacteria by the action of surface polymer:lipid A-core ligase and by determinants of polymer chain length. Mol Microbiol 23: 629638.
  • 32
    Wyckoff, T.J.O., Raetz, C.R.H., Jackman, J.E. (1998) Antibacterial and anti-inflammatory agents that target endotoxin. Trends Microbiol 6: 154159.
  • 33
    Yethon, J.A., Heinrichs, D.E., Monteiro, M.A., Perry, M.B., Whitfield, C. (1998) Involvement of waaY, waaQ, and waaP in the modification of Escherichia coli lipopolysaccharide, and their role in the formation of a stable outer membrane. J Biol Chem (in press).