• 1
    Argüelles, J.C., Mbonyi, K., Van Aelst, L., Vanhalewyn, M., Jans, A.W.H., Thevelein, J.M. (1990) Absence of glucose-induced cAMP signaling in the Saccharomyces cerevisiae mutants cat1 and cat3 which are deficient in derepression of glucose-repressible proteins. Arch Microbiol 154: 199205.
  • 2
    Belazzi, T., Wagner, A., Wieser, R., Schanz, M., Adam, G., Hartig, A., et al (1991) Negative regulation of transcription of the Saccharomyces cerevisiae catalase-T (CTT1) gene by cAMP is mediated by a positive control element. EMBO J 10: 585592.
  • 3
    Berke, H.L. & Rothstein, A. (1957) Metabolism of storage carbohydrates in yeast, studied with glucose-1-14C and dinitrophenol. Arch Biochem Biophys 72: 380395.
  • 4
    Boeke, J.D. & Sandmeyer, S.B. (1991) Yeast transposable elements. In The Molecular and Cellular Biology of the Yeast Saccharomyces. Vol. 1. Genome Dynamics, Protein Synthesis, and Energetics. Broach, J.R., Pringle, J.R., and Jones, E.W. (eds). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, pp. 193261.
  • 5
    Broach, J.R. & Deschenes, R.J. (1990) The function of RAS genes in Saccharomyces cerevisiae. Adv Cancer Res 54: 79139.
  • 6
    Broach, J.R., Strathern, J.N., Hicks, J.B. (1979) Transformation in yeast: development of a hybrid cloning vector and isolation of the CAN1 gene. Gene 8: 121133.
  • 7
    Camonis, J.H., Kalékine, M., Gondré, B., Garreau, H., Boy-Marcotte, E., Jacquet, M. (1986) Characterization, cloning and sequence analysis of the CDC25 gene which controls the cyclic AMP level of Saccharomyces cerevisiae. EMBO J 5: 375380.
  • 8
    Caspani, G., Tortora, P., Hanozet, G.M., Guerritore, A. (1985) Glucose-stimulated cAMP increase may be mediated by intracellular acidification in Saccharomyces cerevisiae. FEBS Lett 186: 7579.
  • 9
    Colombo, S., Ma, P., Cauwenberg, L., Winderickx, J., Crauwels, M., Teunissen, A., et al (1998) Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae. EMBO J 17: 33263341.
  • 10
    Crauwels, M., Donaton, M.C.V., Pernambuco, M.B., Winderickx, J., De Winde, J.H., Thevelein, J.M. (1997) The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway. Microbiology 143: 26272637.
  • 11
    Danchin, A. (1993) Phylogeny of adenylyl cyclases. Adv Second Messenger Phosphoprotein Res 27: 109162.
  • 12
    De Vendittis, E., Vitelli, A., Zahn, R., Fasano, O. (1986) Suppression of defective RAS1 and RAS2 functions in yeast by an adenylate cyclase activated by a single amino acid change. EMBO J 5: 36573663.
  • 13
    Durnez, P., Pernambuco, M.B., Oris, E., Arguelles, J.C., Mergelsberg, H., Thevelein, J.M. (1994) Activation of trehalase during growth induction by nitrogen sources in the yeast Saccharomyces cerevisiae depends on the free catalytic subunits of cAMP-dependent protein kinase, but not on functional ras proteins. Yeast 10: 10491064.
  • 14
    Feger, G., De Vendittis, E., Vitelli, A., Masturzo, P., Zahn, R., Verrotti, A.C., et al (1991) Identification of regulatory residues of the yeast adenylyl cyclase. EMBO J 10: 349359.
  • 15
    Field, J., Nikawa, J.-I., Broek, D., MacDonald, B., Rodgers, L., Wilson, I.A., et al (1988) Purification of a RAS-responsive adenylate cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol Cell Biol 8: 21592165.
  • 16
    Gietz, R.D. & Sugino, A. (1988) New-yeast Escherichia coli shuttle vectors constructed with in vitro mutagenized genes lacking six-basepair restriction sites. Gene 74: 527534.
  • 17
    Heideman, W., Casperson, G.F., Bourne, H.R. (1987) Adenylyl cyclase in yeast. Hydrodynamic properties and activation by trypsin. J Biol Chem 262: 70877091.
  • 18
    Hirimburegama, K., Durnez, P., Keleman, J., Oris, E., Vergauwen, R., Mergelsberg, H., et al (1992) Nutrient-induced activation of trehalase in nutrient-starved cells of the yeast Saccharomyces cerevisiae: cAMP is not involved as second messenger. J Gen Microbiol 138: 20352043.
  • 19
    Iida, H. (1988) Multistress resistance of Saccharomyces cerevisiae is generated by insertion of retrotransposon Ty into the 5′ coding region of the adenylate cyclase gene. Mol Cell Biol 8: 55555560.
  • 20
    Kataoka, T., Broek, D., Wigler, M. (1985) DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase. Cell 43: 493505.
  • 21
    Kinney, A.J. & Carman, G.M. (1988) Phosphorylation of yeast phosphatidylserine synthase in vivo and in vitro by cyclic AMP-dependent protein kinase. Proc Natl Acad Sci USA 85: 79627966.
  • 22
    Kraakman, L., Lemaire, K., Ma, P., Teunissen, A.W.R.H., Donaton, M.C.V., Van Dijck, P., et al (1999) A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose. Mol Microbiol 32: 10021012.
  • 23
    Lenzen, G., Masson, P., Jacquemin, J.-M., Danchin, A. (1987) A TY1 element in the CYR1 control region of Saccharomyces cerevisiae strain AB320. FEBS Lett 219: 254258.
  • 24
    Lillie, S.H. & Pringle, J.R. (1980) Reserve carbohydrate metabolism in Saccharomyces cerevisiae: responses to nutrient limitation. J Bacteriol 143: 13841394.
  • 25
    Lin, K., Hwang, P.K., Fletterick, R.J. (1995) Mechanism of regulation in yeast glycogen phosphorylase. J Biol Chem 270: 2683326839.
  • 26
    Ma, P., Gonçalves, T., Maretzek, A., Loureiro-Dias, M.C., Thevelein, J.M. (1997) The lag phase rather than the exponential-growth phase on glucose is associated with a higher cAMP level in wild-type and cAPK-attenuated strains of the yeast Saccharomyces cerevisiae. Microbiology 143: 34513459.
  • 27
    Ma, P., Wera, S., Van Dijck, P., Thevelein, J.M. (1999) The PDE1 encoded low-affinity phosphodiesterase in the yeast Saccharomyces cerevisiae has a specific function in controlling agonist-induced cAMP signalling. Mol Biol Cell 10: 91104.
  • 28
    Marshall, M.S., Gibbs, J.B., Scolnick, E.M., Sigal, I.S. (1988) An adenylate cyclase from Saccharomyces cerevisiae that is stimulated by RAS proteins with effector mutations. Mol Cell Biol 8: 5261.
  • 29
    Matsumoto, K., Uno, I., Ishikawa, T. (1984) Identification of the structural gene and nonsense alleles for adenylate cyclase in Saccharomyces cerevisiae. J Bacteriol 157: 277282.
  • 30
    Mbonyi, K., Beullens, M., Detremerie, K., Geerts, L., Thevelein, J.M. (1988) Requirement of one functional RAS gene and inability of an oncogenic ras-variant to mediate the glucose-induced cAMP signal in the yeast Saccharomyces cerevisiae. Mol Cell Biol 8: 30513057.
  • 31
    Mbonyi, K., Van Aelst, L., Argüelles, J.C., Jans, A.W.H., Thevelein, J.M. (1990) Glucose-induced hyperaccumulation of cyclic AMP and defective glucose repression in yeast strains with reduced activity of cyclic AMP-dependent protein kinase. Mol Cell Biol 10: 45184523.
  • 32
    Mintzer, K.A. & Field, J. (1995) Yeast adenylyl cyclase assays. In Small Gtpases and Their Regulators, Part A. Der, W.E., Balch, C.J., and Hall, A. (eds). New York: Academic Press, pp. 468476.
  • 33
    Müller, D. & Holzer, H. (1981) Regulation of fructose-1,6-bisphosphatase in yeast by phosphorylation/dephosphorylation. Biochem Biophys Res Commun 103: 926933.
  • 34
    Nakafuku, M., Obara, T., Kaibuchi, K., Miyajima, I., Miyajima, A., Itoh, H., et al (1988) Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions. Proc Natl Acad Sci USA 85: 13741378.
  • 35
    Neves, M.J., Terenzi, H.F., Leone, F.A., Jorge, J.A. (1994) Quantification of trehalose in biological samples with a conidial trehalase from the thermophilic fungus Humicola grisea var. thermoidea. World J Microbiol Biotechnol 10: 1719.
  • 36
    Nikawa, J., Cameron, S., Toda, T., Ferguson, K.W., Wigler, M. (1987) Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae. Genes Dev 1: 931937.
  • 37
    Pernambuco, M.B., Winderickx, J., Crauwels, M., Griffioen, G., Mager, W.H., Thevelein, J.M. (1996) Glucose-triggered signalling in Saccharomyces cerevisiae: different requirements for sugar phosphorylation between cells grown on glucose and those grown an non-fermentable carbon sources. Microbiology 142: 17751782.
  • 38
    Van Der Plaat, J.B. (1974) Cyclic 3′,5′-adenosine monophosphate stimulates trehalose degradation in baker's yeast. Biochem Biophys Res Commun 56: 580587.
  • 39
    Randez-Gil, F., Bojunga, N., Proft, M., Entian, K.D. (1997) Glucose derepression of gluconeogenic enzymes in Saccharomyces cerevisiae correlates with phosphorylation of the gene activator Cat8p. Mol Cell Biol 17: 25022510.
  • 40
    Ruis, H. & Schuller, C. (1995) Stress signaling in yeast. Bioessays 17: 959965.
  • 41
    Salomon, Y., Londos, C., Rodbell, M. (1974) A highly sensitive adenylate cyclase assay. Anal Biochem 58: 541548.
  • 42
    Sambrook, J., Fritsch, E.F., Maniatis, T. (1989) Molecular Cloning: a Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
  • 43
    Sanger, F., Nicklen, S., Coulson, A.R. (1977) DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74: 54635467.
  • 44
    Sherman, F., Fink, G.R., Hicks, J.B. (1986) Methods in Yeast Genetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
  • 45
    Stratford, M. & Anslow, P.A. (1998) Evidence that sorbic acid does not inhibit yeast as a classic ‘weak acid preservative’. Lett Appl Microbiol 27: 203206.
  • 46
    Tanaka, K., Matsumoto, K., Toh-e, A. (1989) Ira1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae. Mol Cell Biol 9: 757768.
  • 47
    Tanaka, K., Nakafuku, M., Tamanoi, F., Kaziro, Y., Matsumoto, K., Toh-e, A. (1990) IRA2, a second gene in Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian Ras GTP-ase activating protein. Mol Cell Biol 10: 43034313.
  • 48
    Tatchell, K. (1993) RAS genes in the budding yeast Saccharomyces cerevisiae. In Signal Transduction Prokaryotic and Simple Eukaryotic Systems. Kurjan, J., and Taylor, B.J. (eds). New York: Academic Press, pp. 147188.
  • 49
    Thevelein, J.M. (1988) Regulation of trehalase activity by phosphorylation–dephosphorylation during developmental transitions in fungi. Exp Mycol 12: 112.
  • 50
    Thevelein, J.M. (1991) Fermentable sugars and intracellular acidification as specific activators of the Ras–adenylate cyclase signalling pathway in yeast: the relationship to nutrient-induced cell cycle control. Mol Microbiol 5: 13011307.
  • 51
    Thevelein, J.M. (1992) The RAS-adenylate cyclase pathway and cell cycle control in Saccharomyces cerevisiae. Antonie Leeuwenhoek, J Microbiol 62: 109130.
  • 52
    Thevelein, J.M. (1994) Signal transduction in yeast. Yeast 10: 17531790.
  • 53
    Thevelein, J.M., Beullens, M., Honshoven, F., Hoebeeck, G., Detremerie, K., Griewel, B., et al (1987a) Regulation of the cAMP level in the yeast Saccharomyces cerevisiae: the glucose-induced cAMP signal is not mediated by a transient drop in the intracellular pH. J Gen Microbiol 133: 21972205.
  • 54
    Thevelein, J.M., Beullens, M., Honshoven, F., Hoebeeck, G., Detremerie, K., Den Hollander, J.A., et al (1987b) Regulation of the cAMP level in the yeast Saccharomyces cerevisiae: intracellular pH and the effect of membrane depolarizing compounds. J Gen Microbiol 133: 21912196.
  • 55
    Thomas, B.J. & Rothstein, R.J. (1989) Elevated recombination rates in transcriptionally active DNA. Cell 56: 619630.
  • 56
    Toda, T., Uno, I., Ishikawa, T., Powers, S., Kataoka, T., Broek, D., et al (1985) In yeast, Ras proteins are controlling elements of adenylate cyclase. Cell 40: 2736.
  • 57
    Toda, T., Cameron, S., Sass, P., Zoller, M., Wigler, M. (1987a) Three different genes in Saccharomyces cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 50: 277287.
  • 58
    Toda, T., Cameron, S., Sass, P., Zoller, M., Scott, J.D., McBullen, B., et al (1987b) Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae. Mol Cell Biol 7: 13711377.
  • 59
    Uno, I., Matsumoto, K., Adachi, K., Ishikawa, T. (1983) Genetic and biochemical evidence that trehalase is a substrate of cAMP-dependent protein kinase in yeast. J Biol Chem 258: 1086710872.
  • 60
    Uno, I., Mitsuzawa, H., Tanaka, K., Oshima, T., Ishikawa, T. (1987) Identification of the domain of Saccharomyces cerevisiae adenylate cyclase associated with the regulatory function of RAS products. Mol Gen Genet 210: 187194.
  • 61
    Varimo, K. & Londesborough, J. (1976) Solubilization and other studies on adenylate cyclase of baker's yeast. Biochem J 159: 363370.
  • 62
    Xue, Y., Batlle, M., Hirsch, J.P. (1998) GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p G subunit and functions in a Ras-independent pathway. EMBO J 17: 19962007.
  • 63
    Yamawaki-Kataoka, Y., Tamaoki, T., Choe, H.-R., Tanaka, H., Kataoka, T. (1989) Adenylate cyclases in yeast: a comparison of the genes from Schizosaccharomyces pombe and Saccharomyces cerevisiae. Proc Natl Acad Sci USA 86: 56935697.
  • 64
    Yanisch-Perron, C., Viera, J., Messing, J. (1985) Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33: 103119.