• 1
    Allaoui, A., Mounier, J., Prevost, M.-C., Sansonetti, P.J., Parsot, C. (1992) icsB : a Shigella flexneri virulence gene necessary for the lysis of protrusions during intercellular spread. Mol Microbiol 6: 16051616.
  • 2
    Baldini, M.M., Kaper, J.B., Levine, M.M., Candy, D.C., Moon, H.W. (1983) Plasmid-mediated adhesion in enteropathogenic Escherichia coli. J Pediatr Gastroenterol Nutr 2: 534538.
  • 3
    Bieber, D., Ramer, S.W., Wu, C.-Y., Murray, W.J., Tobe, T., Fernandez, R., Schoolnik, G.K. (1998) Type IV pili, transient bacterial aggregates, and virulence of enteropathogenic Escherichia coli. Science 280: 21142118.
  • 4
    Bilge, S.S., Vary, J.J.C., Dowell, S.F., Tarr, P.I. (1996) Role of the Escherichia coli O157:H7 O side chain in adherence and analysis of an rfb locus. Infect Immun 64: 47954901.
  • 5
    Boyer, H.W. & Roulland-Dussoix, D. (1969) A complementation analysis of the restriction and modification of DNA in Escherichia coli. J Mol Biol 41: 459472.
  • 6
    Brosius, J. (1984) Plasmid vectors for the selection of promoters. Gene 27: 151160.
  • 7
    Cravioto, A., Gross, R., Scotland, S., Rowe, B. (1979) An adhesive factor found in strains of Escherichia coli belonging to the traditional infantile enteropathogenic serotypes. Curr Microbiol 3: 9599.
  • 8
    Donnenberg, M.S., Giron, J.A., Nataro, J.P., Kaper, J.B. (1992) A plasmid-encoded type IV fimbrial gene of enteropathogenic Escherichia coli associated with localized adherence. Mol Microbiol 6: 34273437.
  • 9
    Donnenberg, M.S., Yu, J., Kaper, J.B. (1993)A second chromosomal gene necessary for intimate attachment of enteropathogenic Escherichia coli to epithelial cells. J Bacteriol 175: 46704680.
  • 10
    Donnenberg, M.S., Kaper, J.B., Finlay, B.B. (1997) Interactions between enteropathogenic Escherichia coli and host epithelial cells. Trends Microbiol 5: 109114.
  • 11
    Elliott, S.J., Wainwright, L.A., McDaniel, T.K., Jarvis, K.G., Deng, Y.-K., Lai, L.-C., et al (1998) The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia coli E2348/69. Mol Microbiol 28: 14.
  • 12
    Furuchi, T., Kashiwagi, K., Kobayashi, H., Igarashi, K. (1991) Characterization of the gene for a spermidine and putrescine transport system that maps at 15 min on the Escherichia coli chromosome. J Biol Chem 266: 2092820933.
  • 13
    Giron, J.A., Ho, A.S., Schoolnik, G.K. (1991) An inducible bundle-forming pilus of enteropathogenic Escherichia coli. Science 254: 710713.
  • 14
    Gomes, T.A., Vieira, M.A., Wachsmuth, I.K., Blake, P.A., Trabulsi, L.R. (1989) Serotype-specific prevalence of Escherichia coli strains with EPEC adherence factor genes in infants with and without diarrhea in Sao Paulo, Brazil. J Infect Dis 160: 131135.
  • 15
    Gomez-Duarte, O.G. & Kaper, J.B. (1995) A plasmid-encoded regulatory region activates chromosomal eaeA expression in enteropathogenic Escherichia coli. Infect Immun 63: 17671776.
  • 16
    Hanahan, D. (1983) Studies on transformation of Escherichia coli with plasmids. J Mol Biol 166: 557580.
  • 17
    Higgins, D.G. (1994) CLUSTAL V: multiple alignment of DNA and protein sequences. Methods Mol Biol 25: 307318.
  • 18
    Jarvis, K.G., Giron, J.A., Jerse, A.E., McDaniel, T.K., Donnenberg, M.S., Kaper, J.B. (1995) Enteropathogenic Escherichia coli contains a putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation. Proc Natl Acad Sci USA 92: 79968000.
  • 19
    Jerse, A.E., Yu, J., Tall, B.D., Kaper, J.B. (1990) A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells. Proc Natl Acad Sci USA 87: 78397843.
  • 20
    Kenny, B. & Finlay, B.B. (1995)Protein secretion by enteropathogenic Escherichia coli is essential for transducing signals to epithelial cells. Proc Natl Acad Sci USA 92: 79917995.
  • 21
    Kenny, B., Lai, L., Finlay, B.B., Donnenberg, M.S. (1996)EspA, a protein secreted by enteropathogenic Escherichia coli, is required to induce signals in epithelial cells. Mol Microbiol 20: 313324.
  • 22
    Kenny, B., DeVinney, R., Stein, M., Reinscheid, D.J., Frey, E.A., Finlay, B.B. (1997) Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells. Cell 91: 511520.
  • 23
    Knutton, S., Boldwin, T., Williams, P.H., McNeish, A.S. (1989) Actin accumulation at sites of bacterial adhesion to tissue culture cells: basis of a new diagnostic test for enteropathogenic and enterohemorrhagic Escherichia coli. Infect Immun 57: 12901298.
  • 24
    Knutton, S., Rosenshine, I., Pallen, M.J., Nisan, I., Neves, B.C., Bain, C., et al (1998) A novel EspA-associated surface organelle of enteropathogenic Escherichia coli involved in protein translocation into epithelial cells. EMBO J 17: 21662176.
  • 25
    Lai, L.-C., Wainwright, L.A., Stone, K.D., Donnenberg, M.S. (1997) A third secreted protein that is encoded by the enteropathogenic Escherichia coli pathogenicity island is required for transduction of signals and for attaching and effacing activities in host cells. Infect Immun 65: 22112217.
  • 26
    Law, D. (1994) Adhesion and its role in the virulence of enteropathogenic Escherichia coli. Clin Microbiol Rev 7: 152173.
  • 27
    Levine, M.M. (1987) Escherichia coli that cause diarrhea: enterotoxigenic, enteropathogenic, enteroinvasive, enterohemorrhagic, and enteroadherent. J Infect Dis 155: 377385.
  • 28
    Levine, M.M., Bergquist, E.J., Nalin, D.R., Waterman, D.H., Hornick, R.B., Young, C.R., et al (1978) Escherichia coli strains that cause diarrhea but do not produce heat-labile or heat-stable enterotoxins and are non-invasive. Lancet 1: 11191122.
  • 29
    Levine, M.M., Nataro, J.P., Karch, H., Baldini, M.M., Kaper, J.B., Black, R.E., et al (1985) The diarrheal response of humans to some classic serotypes of enteropathogenic Escherichia coli is dependent on a plasmid encoding an enteroadhesiveness factor. J Infect Dis 152: 550559.
  • 30
    McDaniel, T.K., Jarvis, K.G., Donnenberg, M.S., Kaper, J.B. (1995) A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens. Proc Natl Acad Sci USA 92: 16641668.
  • 31
    McKee, M.L. & O'Brien, A.D. (1996) Truncated enterohemorrhagic Escherichia coli (EHEC) O157:H7 Intimin (EaeA) fusion proteins promote adherence of EHEC strains to HEp–2 cells. Infect Immun 64: 22252233.
  • 32
    Menard, R., Sansonetti, P., Parsot, C., Vasselon, T. (1994) Extracellular association and cytoplasmic partitioning of the IpaB and IpaC Invasins of S Flexneri. Cell 79: 515525.
  • 33
    Miller, V.L. & Mekalanos, J.J. (1988) A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR. J Bacteriol 170: 25752583.
  • 34
    Moon, H.W., Whipp, S.C., Argenzio, R.A., Levine, M.M., Giannella, R.A. (1983) Attaching and effacing activities of rabbit and human enteropathogenic Escherichia coli in pig and rabbit intestines. Infect Immun 41: 13401351.
  • 35
    Nataro, J.P., Scaletsky, I., Kaper, J., Levine, M., Trabulsi, L. (1985) Plasmid-mediated factors conferring diffuse and localized adherence of enteropathogenic Escherichia coli. Infect Immun 48: 378383.
  • 36
    Nataro, J.P., Maher, K., Mackie, P., Kaper, J. (1987) Characterization of plasmids encoding the adherence factor of enteropathogenic Escherichia coli. Infect Immun 55: 23702377.
  • 37
    Puente, J.L., Bieber, D., Ramer, S.W., Murray, W., Schoolnik, G.K. (1996) The bundle-forming pili of enteropathogenic Escherichia coli : transcriptional regulation by environmental signals. Mol Microbiol 20: 87100.
  • 38
    Riley, L.W., Junio, L.N., Libaek, L.B., Schoolnik, G.K. (1987) Plasmid-encoded expression of lipopolysaccharide O-antigenic polysaccharide in enteropathogenic Escherichia coli. Infect Immun 55: 20522056.
  • 39
    Sasakawa, C., Adler, B., Tobe, T., Okada, N., Nagai, S., Komatsu, K., Yoshikawa, M. (1989) Functional organization and nucleotide sequence of virulence Region-2 on the large virulence plasmid in Shigella flexneri 2a. Mol Microbiol 3: 11911201.
  • 40
    Sohel, I., Puente, J.L., Murray, W.J., Vuopio-Varkila, J., Schoolnik, G.K. (1993) Cloning and characterization of the bundle-forming pilin gene of enteropathogenic Escherichia coli and its distribution in Salmonella serotypes. Mol Microbiol 7: 563575.
  • 41
    Sohel, I., Puente, J.L., Ramer, S.W., Bieber, D., Wu, C.-Y., Schoolnik, G.K. (1996) Enteropathogenic Escherichia coli : identification of a gene cluster coding for bundle-forming pilus morphogenesis. J Bacteriol 178: 26132628.
  • 42
    Stein, M.A., Leung, K.Y., Zwick, M., Portillo, F.G., Finlay, B.B. (1996) Identification of a Salmonella virulence gene required for formation of filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Mol Microbiol 20: 151164.
  • 43
    Stone, K.D., Zhang, H.-Z., Carlson, L.K., Donnenberg, M.S. (1996) A cluster of fourteen genes from enteropathogenic Escherichia coli is sufficient for the biogenesis of a type IV pilus. Mol Microbiol 20: 325337.
  • 44
    Tobe, T., Schoolnik, G.K., Sohel, I., Bustamante, V.H., Puente, J.L. (1996) Cloning and characterization of bfpTVW, genes required for the transcriptional activation of bfpA in enteropathogenic Escherichia coli. Mol Microbiol 21: 963975.
  • 45
    Waineright, L.A. & Kaper, J.B. (1998) EspB and EspD require a specific chaperone for proper secretion from enteropathogenic Escherichia coli. Mol Microbiol 27: 12471260.
  • 46
    Zhang, H.-Z., Lory, S., Donnenberg, M.S. (1994) A plasmid-encoded prepilin peptidase gene from enteropathogenic Escherichia coli. J Bacteriol 176: 68856891.