Regulation of Escherichia coli cell division genes ftsA and ftsZ by the two-component system rcsC–rcsB

Authors

  • Fabrice Carballès,

    1. Laboratoire de Microbiologie et de Génétique Moléculaire, Centre National de la Recherche Scientifique, 118 Route de Narbonne, 31062 Toulouse, France.
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  • Claire Bertrand,

    1. Laboratoire de Microbiologie et de Génétique Moléculaire, Centre National de la Recherche Scientifique, 118 Route de Narbonne, 31062 Toulouse, France.
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  • Jean-Pierre Bouché,

    1. Laboratoire de Microbiologie et de Génétique Moléculaire, Centre National de la Recherche Scientifique, 118 Route de Narbonne, 31062 Toulouse, France.
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  • Kaymeuang Cam

    1. Laboratoire de Microbiologie et de Génétique Moléculaire, Centre National de la Recherche Scientifique, 118 Route de Narbonne, 31062 Toulouse, France.
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Kaymeuang Cam. E-mail cam@ibcg.biotoul.fr; Tel. (+33) 561 33 59 63; Fax (+33) 561 33 58 86.

Abstract

Genes rcsC and rcsB form a two-component system in which rcsC encodes the sensor element and rcsB the regulator. In Escherichia coli, the system positively regulates the expression of the capsule operon, cps, and of the cell division gene ftsZ. We report the identification of the promoter and of the sequences required for rcsB-dependent stimulation of ftsZ expression. The promoter, ftsA1p, located in the ftsQ coding sequence, co-regulates ftsA and ftsZ. The sequences required for rcsB activity are immediately adjacent to this promoter.

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