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References

  • 1
    Akins, D.R., Caimano, M.J., Yang, X., Cerna, F., Norgard, M.V., and Radolf, J.D. (1999) Molecular and evolutionary analysis of Borrelia burgdorferi 297 circular plasmid-encoded lipoproteins with OspE- and OspF-like leader peptides. Infect Immun 67: 15261532.
  • 2
    Alm, A., Ling, L., Moir, D., King, B., Brown, E., Doig, P., et al (1999) Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature 397: 176180.
  • 3
    Altschul, S.F., Madden, T.L., Schaffer, A.A., Zhang, J., Zhang, Z., Miller, W., et al (1997) Gapped Blast and Psi-Blast: a new generation of protein database search programs. Nucleic Acids Res 25: 33893402.
  • 4
    Anderson, J.F., Flavell, R.A., Magnarelli, L.A., Barthold, S.W., Kantor, F.S., Wallich, R., et al (1996) Novel Borrelia burgdorferi isolates from Ixodes scapularis and Ixodes dentatus ticks feeding on humans. J Clin Microbiol 34: 524529.
  • 5
    Andersson, S.G., Zomorodipour, A., Andersson, J.O., Sicheritz-Ponten, T., Alsmark, U.C., Podowski, R.M., et al (1998) The genome sequence of Rickettsia prowazekii and the origin of mitochondria. Nature 396: 133140.
  • 6
    Bancroft, I., and Wolk, C.P. (1989) Characterization of an insertion sequence (IS891) of novel structure from the cyanobacterium Anabaena sp. strain M-131. J Bacteriol 171: 59495954.
  • 7
    Barbour, A.G. (1988) Plasmid analysis of Borrelia burgdorferi, the Lyme disease agent. J Clin Microbiol 26: 475478.
  • 8
    Barbour, A.G. (1993) Linear DNA of Borrelia species and antigenic variation. Trends Microbiol 1: 236239.
  • 9
    Barbour, A.G., and Garon, C.F. (1987) Linear plasmids of the bacterium Borrelia burgdorferi have covalently closed ends. Science 237: 409411.
  • 10
    Barbour, A.G., Carter, C.J., Bundoc, V., and Hinnebusch, J. (1996) The nucleotide sequence of a linear plasmid of Borrelia burgdorferi reveals similarities to those of circular plasmids of other prokaryotes. J Bacteriol 178: 66356639.
  • 11
    Baril, C., Richaud, C., Baranton, G., and Saint Girons, I.S. (1989) Linear chromosome of Borrelia burgdorferi. Res Microbiol 140: 507516.
  • 12
    Blattner, F.R., Plunkett, G., Bloch, C.A., Perna, N.T., Burland, V., Riley, M., et al (1997) The complete genome sequence of Escherichia coli K-12. Science 277: 14531474.
  • 13
    Bono, J.L., Tilly, K., Stevenson, B., Hogan, D., and Rosa, P. (1998) Oligopeptide permease in Borrelia burgdorferi : putative peptide-binding components encoded by both chromosomal and plasmid loci. Microbiology 144: 10331044.
  • 14
    Burgdorfer, W., Barbour, A.G., Hayes, S.F., Benach, J.L., Grunwaldt, E., and Davis, J.P. (1982) Lyme disease — a tick-borne spirochetosis? Science 216: 13171319.
  • 15
    Busch, U., Teufel, C.H., Boehmer, R., Wilske, B., and Preac-Mursic, V. (1995) Molecular characterization of Borrelia burgdorferi sensu lato strains by pulsed-field gel electrophoresis. Electrophoresis 16: 744747.
  • 16
    Busch, U., Hizo-Teufel, C., Boehmer, R., Fingerle, V., Nitschko, H., Wilske, B., et al (1996) Three species of Borrelia burgdorferi sensu lato (B. burgdorferi sensu stricto, B afzelii, and B. garinii ) identified from cerebrospinal fluid isolates by pulsed-field gel electrophoresis and PCR. J Clin Microbiol 34: 10721078.
  • 17
    Carlyon, J.A., LaVoie, C., Sung, S.Y., and Marconi, R.T. (1998) Analysis of the organization of multicopy linear- and circular-plasmid-carried open reading frames in Borrelia burgdorferi sensu lato isolates. Infect Immun 66: 11491158.
  • 18
    Casjens, S. (1998) The diverse and dynamic structure of bacterial genomes. Annu Rev Genet 32: 339377.
  • 19
    Casjens, S. (1999) Evolution of the linear DNA replicons of the Borrelia spirochetes. Curr Opin Microbiol 2: 529534.DOI: 10.1016/s1369-5274(99)00012-0
  • 20
    Casjens, S., Hatfull, G., and Hendrix, R. (1992) Evolution of dsDNA tailed-bacteriophage genomes. Semin Virol 3: 383397.
  • 21
    Casjens, S., and Huang, W.M. (1993) Linear chromosomal physical and genetic map of Borrelia burgdorferi, the Lyme disease agent. Mol Microbiol 8: 967980.
  • 22
    Casjens, S., Delange, M., Ley, 3rd, H.L., Rosa, P., and Huang, W.M. (1995) Linear chromosomes of Lyme disease agent spirochetes: genetic diversity and conservation of gene order. J Bacteriol 177: 27692780.
  • 23
    Casjens, S., Van Vugt, R., Tilly, K., Rosa, P.A., and Stevenson, B. (1997a) Homology throughout the multiple 32-kilobase circular plasmids present in Lyme disease spirochetes. J Bacteriol 179: 217227.
  • 24
    Casjens, S., Murphy, M., DeLange, M., Sampson, L., Van Vugt, R., and Huang, W.M. (1997b) Telomeres of the linear chromosomes of Lyme disease spirochaetes: nucleotide sequence and possible exchange with linear plasmid telomeres. Mol Microbiol 26: 581596.
  • 25
    Champion, C.I., Blanco, D.R., Skare, J.T., Haake, D.A., Giladi, M., Foley, D., et al (1994) A 9.0-kilobase-pair circular plasmid of Borrelia burgdorferi encodes an exported protein: evidence for expression only during infection. Infect Immun 62: 26532661.
  • 26
    Cheetham, B.F., and Katz, M.E. (1995) A role for bacteriophages in the evolution and transfer of bacterial virulence determinants. Mol Microbiol 18: 201208.
  • 27
    Claros, M.G., and Von Heijne, G. (1994) Toppred Ii: an improved software for membrane protein structure predictions. Comput Appl Biosci 10: 685686.
  • 28
    Cole, S.T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., et al. (1998) Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393: 537544.
  • 29
    Cornell, K.A., and Riscoe, M.K. (1998) Cloning and expression of Escherichia coli 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase: identification of the pfs gene product. Biochim Biophys Acta 1396: 814.
  • 30
    Davidson, B.E., MacDougall, J., and Saint Girons, I. (1992) Physical map of the linear chromosome of the bacterium Borrelia burgdorferi 212, a causative agent of Lyme disease, and localization of rRNA genes. J Bacteriol 174: 37663774.
  • 31
    Donadio, S., and Staver, M.J. (1993) IS1136, an insertion element in the erythromycin gene cluster of Saccharopolyspora erythraea. Gene 126: 147151.
  • 32
    Douglas, S.E. (1994) Dna Strider. A Macintosh program for handling protein and nucleic acid sequences. Methods Mol Biol 25: 181194.
  • 33
    Dunn, J.J., Buchstein, S.R., Butler, L.L., Fisenne, S., Polin, D.S., Lade, B.N., et al (1994) Complete nucleotide sequence of a circular plasmid from the Lyme disease spirochete, Borrelia burgdorferi. J Bacteriol 176: 27062717.
  • 34
    Dykhuizen, D.E., Polin, D.S., Dunn, J.J., Wilske, B., Preac-Mursic, V., Dattwyler, R.J., et al (1993) Borrelia burgdorferi is clonal: implications for taxonomy and vaccine development. Proc Natl Acad Sci USA 90: 1016310167.
  • 35
    Eddy, S.R. (1998) Profile hidden Markov models. Bioinformatics 14: 755763.
  • 36
    El Hage, N., Lieto, L.D., Stevenson, B. (1999) Stability of erp loci during Borrelia burgdorferi infection: recombination is not required for chronic infection of immunocompetent mice. Infect Immun 67: 31463150.
  • 37
    Feng, S., Das, S., Barthold, S.W., and Fikrig, E. (1996) Characterization of two genes, p11 and p5, on the Borrelia burgdorferi 49-kilo base linear plasmid. Biochim Biophys Acta 1307: 270272.
  • 38
    Feng, S., Hodzic, E., Stevenson, B., and Barthold, S.W. (1998) Humoral immunity to Borrelia burgdorferi N40 decorin binding proteins during infection of laboratory mice. Infect Immun 66: 28272835.
  • 39
    Ferdows, M.S., and Barbour, A.G. (1989) Megabase-sized linear DNA in the bacterium Borrelia burgdorferi, the Lyme disease agent. Proc Natl Acad Sci USA 86: 59695973.
  • 40
    Ferdows, M.S., Serwer, P., Griess, G.A., Norris, S.J., and Barbour, A.G. (1996) Conversion of a linear to a circular plasmid in the relapsing fever agent Borrelia hermsii. J Bacteriol 178: 793800.
  • 41
    Fikrig, E., Liu, B., Fu, L.L., Das, S., Smallwood, J.I., Flavell, R.A., et al (1995a) An ospA frame shift, identified from DNA in Lyme arthritis synovial fluid, results in an outer surface protein A that does not bind protective antibodies. J Immunol 155: 57005704.
  • 42
    Fikrig, E., Tao, H., Barthold, S.W., and Flavell, R.A. (1995b) Selection of variant Borrelia burgdorferi isolates from mice immunized with outer surface protein A or B. Infect Immun 63: 16581662.
  • 43
    Fleischmann, R.D., Adams, M.D., White, O., Clayton, R.A., Kirkness, E.F., Kerlavage, A.R., et al (1995) Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269: 496512.
  • 44
    Fraser, C.M., Gocayne, J.D., White, O., Adams, M.D., Clayton, R.A., Fleischmann, R.D., et al (1995) The minimal gene complement of Mycoplasma genitalium. Science 270: 397403.
  • 45
    Fraser, C.M., Casjens, S., Huang, W.M., Sutton, G.G., Clayton, R., Lathigra, R., et al (1997) Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature 390: 580586.
  • 46
    Fraser, C.M., Norris, S.J., Weinstock, G.M., White, O., Sutton, G.G., Dodson, R., et al (1998) Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science 281: 375388.
  • 47
    Fsihi, H., De Rossi, E., Salazar, L., Cantoni, R., Labo, M., Riccardi, G., et al (1996) Gene arrangement and organization in a approximately 76 kb fragment encompassing the oriC region of the chromosome of Mycobacterium leprae. Microbiology 142: 31473161.
  • 48
    Fukunaga, M., and Hamase, A. (1995) Outer surface protein C gene sequence analysis of Borrelia burgdorferi sensu lato isolates from Japan. J Clin Microbiol 33: 24152420.
  • 49
    Fukunaga, M., Hamase, A., Okada, K., and Nakao, M. (1996) Borrelia tanukii sp. nov. & Borrelia turdae sp. nov. found from ixodid ticks in Japan: rapid species identification by 16S rRNA gene-targeted PCR analysis. Microbiol Immunol 40: 877881.
  • 50
    Gesteland, R.F., and Atkins, J.F. (1996) Recoding: dynamic reprogramming of translation. Annu Rev Biochem 65: 741768.
  • 51
    Gilmore, Jr, R.D., and Mbow, M.L. (1998) A monoclonal antibody generated by antigen inoculation via tick bite is reactive to the Borrelia burgdorferi Rev protein, a member of the 2.9 gene family locus. Infect Immun 66: 980986.
  • 52
    Gilmore, Jr, R.D., Kappel, K.J., and Johnson, B.J. (1997) Molecular characterization of a 35-kilodalton protein of Borrelia burgdorferi, an antigen of diagnostic importance in early Lyme disease. J Clin Microbiol 35: 8691.
  • 53
    Guina, T., and Oliver, D.B. (1997) Cloning and analysis of a Borrelia burgdorferi membrane-interactive protein exhibiting haemolytic activity. Mol Microbiol 24: 12011213.
  • 54
    Gulig, P.A., Caldwell, A.L., and Chiodo, V.A. (1992) Identification, genetic analysis and DNA sequence of a 7.8 kb virulence region of the Salmonella typhimurium virulence plasmid. Mol Microbiol 6: 13951411.
  • 55
    Guttman, D.S., Wang, P.W., Wang, I.N., Bosler, E.M., Luft, B.J., and Dykhuizen, D.E. (1996) Multiple infections of Ixodes scapularis ticks by Borrelia burgdorferi as revealed by single-strand conformation polymorphism analysis. J Clin Microbiol 34: 652656.
  • 56
    Hall, B.G., Yokoyama, S., and Calhoun, D.H. (1983) Role of cryptic genes in microbial evolution. Mol Biol Evol 1: 109124.
  • 57
    Hayes, S.F., Burgdorfer, W., and Barbour, A.G. (1983) Bacteriophage in the Ixodes dammini spirochete, etiological agent of Lyme disease. J Bacteriol 154: 14361439.
  • 58
    Hinnebusch, J., and Barbour, A.G. (1991) Linear plasmids of Borrelia burgdorferi have a telomeric structure and sequence similar to those of a eukaryotic virus. J Bacteriol 173: 72337239.
  • 59
    Hinnebusch, J., and Barbour, A.G. (1992) Linear- and circular-plasmid copy numbers in Borrelia burgdorferi. J Bacteriol 174: 52515257.
  • 60
    Hinnebusch, J., Bergstrom, S., and Barbour, A.G. (1990) Cloning and sequence analysis of linear plasmid telomeres of the bacterium Borrelia burgdorferi. Mol Microbiol 4: 811820.
  • 61
    Hughes, C.A., Kodner, C.B., and Johnson, R.C. (1992) DNA analysis of Borrelia burgdorferi NCH-1, the first northcentral U.S. human Lyme disease isolate. J Clin Microbiol 30: 698703.
  • 62
    Hyde, F.W., and Johnson, R.C. (1988) Characterization of a circular plasmid from Borrelia burgdorferi, etiologic agent of Lyme disease. J Clin Microbiol 26: 22032205.
  • 63
    Jauris-Heipke, S., Liegl, G., Preac-Mursic, V., Rossler, D., Schwab, E., Soutschek, E., et al (1995) Molecular analysis of genes encoding outer surface protein C (OspC) of Borrelia burgdorferi sensu lato: relationship to ospA genotype and evidence of lateral gene exchange of OspC. J Clin Microbiol 33: 18601866.
  • 64
    Johnson, R.C., Hyde, F.W., and Rumpel, C.M. (1984) Taxonomy of the Lyme disease spirochetes. Yale J Biol Med 57: 529537.
  • 65
    Kawabata, H., Myouga, F., Inagaki, Y., Murai, N., and Watanabe, H. (1998) Genetic and immunological analyses of Vls (VMP-like sequences) of Borrelia burgdorferi. Microb Pathog 24: 155166.DOI: 10.1006/mpat.1997.0183
  • 66
    Kitten, T., and Barbour, A.G. (1992) The relapsing fever agent Borrelia hermsii has multiple copies of its chromosome and linear plasmids. Genetics 132: 311324.
  • 67
    Koomey, M. (1994) Mechanisms of pilus antigenic variation in Neisseria gonorrheae. In Molecular Genetics of Bacterial Pathogenesis. Miller, V., Kaper, J., Prtnoy, D., and Isberg, R. (eds). Washington, DC: American Society for Microbiology.
  • 68
    Kornacki, J.A., and Oliver, D.B. (1998) Lyme disease-causing Borrelia species encode multiple lipoproteins homologous to peptide-binding proteins of ABC-type transporters. Infect Immun 66: 41154122.
  • 69
    Krause, M., Harwood, J., Fierer, J., and Guiney, D. (1991) Genetic analysis of homology between the virulence plasmids of Salmonella dublin and Yersinia pseudotuberculosis. Infect Immun 59: 18601863.
  • 70
    Lai, C.Y., Baumann, P., and Moran, N. (1996) The endosymbiont (Buchnera sp.) of the aphid Diuraphis noxia contains plasmids consisting of trpEGG and tandem repeats of trpEG pseudogenes. Appl Environ Microbiol 62: 332339.
  • 71
    Lam, T.T., Nguyen, T.P., Montgomery, R.R., Kantor, F.S., Fikrig, E., and Flavell, R.A. (1994) Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease. Infect Immun 62: 290298.
  • 72
    Lawrence, J.G., and Ochman, H. (1997) Amelioration of bacterial genomes: rates of change and exchange. J Mol Evol 44: 383397.
  • 73
    Le Fleche, A., Postic, D., Girardet, K., Peter, O., and Baranton, G. (1997) Characterization of Borrelia lusitaniae sp. nov. by 16S ribosomal DNA sequence analysis. Int J Syst Bacteriol 47: 921925.
  • 74
    Livey, I., Gibbs, C.P., Schuster, R., and Dorner, F. (1995) Evidence for lateral transfer and recombination in OspC variation in Lyme disease Borrelia. Mol Microbiol 18: 257269.
  • 75
    McLean, M.J., Wolfe, K.H., Devine, K.M. (1998) Base composition skews, replication orientation, and gene orientation in 12 prokaryote genomes. J Mol Evol 47: 691696.
  • 76
    Marconi, R.T., Konkel, M.E., and Garon, C.F. (1993a) Variability of osp genes and gene products among species of Lyme disease spirochetes. Infect Immun 61: 26112617.
  • 77
    Marconi, R.T., Samuels, D.S., Schwan, T.G., and Garon, C.F. (1993b) Identification of a protein in several Borrelia species which is related to OspC of the Lyme disease spirochetes. J Clin Microbiol 31: 25772583.
  • 78
    Marconi, R.T., Samuels, D.S., Landry, R.K., and Garon, C.F. (1994) Analysis of the distribution and molecular heterogeneity of the ospD gene among the Lyme disease spirochetes: evidence for lateral gene exchange. J Bacteriol 176: 45724582.
  • 79
    Marconi, R.T., Casjens, S., Munderloh, U.G., and Samuels, D.S. (1996a) Analysis of linear plasmid dimers in Borrelia burgdorferi sensu lato isolates: implications concerning the potential mechanism of linear plasmid replication. J Bacteriol 178: 33573361.
  • 80
    Marconi, R.T., Sung, S.Y., Hughes, C.A., and Carlyon, J.A. (1996b) Molecular and evolutionary analyses of a variable series of genes in Borrelia burgdorferi that are related to ospE and ospF constitute a gene family, and share a common upstream homology box. J Bacteriol 178: 56155626.
  • 81
    Margolis, N., Hogan, D., Tilly, K., and Rosa, P.A. (1994) Plasmid location of Borrelia purine biosynthesis gene homologs. J Bacteriol 176: 64276432.
  • 82
    Mathiesen, D.A., Oliver, Jr, J.H., Kolbert, C.P., Tullson, E.D., Johnson, B.J., Campbell, G.L., et al (1997) Genetic heterogeneity of Borrelia burgdorferi in the United States. J Infect Dis 175: 98107.
  • 83
    Misonne, M.C., Schuttler, M., Dernelle, J.M., De Kesel, M., and Hoet, P.P. (1997) Cloning and sequencing of a species-specific nucleotide fragment of Borrelia burgdorferi sensu stricto, which is repeated in several plasmids of the species. FEMS Microbiol Lett 150: 157164.DOI: 10.1016/s0378-1097(97)00123-7
  • 84
    Morris, D.D., Reeves, R.A., Gibbs, M.D., Saul, D.J., and Bergquist, P.L. (1995) Correction of the beta-mannanase domain of the celC pseudogene from Caldocellulosiruptor saccharolyticus and activity of the gene product on kraft pulp. Appl Environ Microbiol 61: 22622269.
  • 85
    Moxon, E.R., Rainey, P.B., Nowak, M.A., and Lenski, R.E. (1994) Adaptive evolution of highly mutable loci in pathogenic bacteria. Curr Biol 4: 2433.
  • 86
    Munderloh, U.G., Park, Y.J., Dioh, J.M., Fallon, A.M., and Kurtti, T.J. (1993) Plasmid modifications in a tick-borne pathogen, Borrelia burgdorferi, cocultured with tick cells. Insect Mol Biol 1: 195203.
  • 87
    Murai, N., Kamata, H., Nagashima, Y., Yagisawa, H., and Hirata, H. (1995) A novel insertion sequence (IS)-like element of the thermophilic bacterium PS3 promotes expression of the alanine carrier protein-encoding gene. Gene 163: 103107.DOI: 10.1016/0378-1119(95)00384-i
  • 88
    Neubert, U., Schaller, M., Januschke, E., Stolz, W., and Schmieger, H. (1993) Bacteriophages induced by ciprofloxacin in a Borrelia burgdorferi skin isolate. Zentralbl Bakteriol 279: 307315.
  • 89
    Norris, S.J., Carter, C.J., Howell, J.K., and Barbour, A.G. (1992) Low-passage-associated proteins of Borrelia burgdorferi B31: characterization and molecular cloning of OspD, a surface-exposed, plasmid-encoded lipoprotein. Infect Immun 60: 46624672.
  • 90
    Norris, S.J., Howell, J.K., Garza, S.A., Ferdows, M.S., and Barbour, A.G. (1995) High- and low-infectivity phenotypes of clonal populations of in vitro-cultured Borrelia burgdorferi. Infect Immun 63: 22062212.
  • 91
    Ojaimi, C., Davidson, B.E., Saint Girons, I., and Old, I.G. (1994) Conservation of gene arrangement and an unusual organization of rRNA genes in the linear chromosomes of the Lyme disease spirochaetes Borrelia burgdorferi, B. garinii and B. afzelii. Microbiology 140: 29312940.
  • 92
    Pearson, W.R. (1990) Rapid and sensitive sequence comparison with Fastp and Fasta. Methods Enzymol 183: 6398.
  • 93
    Persing, D.H., Mathiesen, D., Podzorski, D., and Barthold, S.W. (1994) Genetic stability of Borrelia burgdorferi recovered from chronically infected immunocompetent mice. Infect Immun 62: 35213527.
  • 94
    Plasterk, R.H., Simon, M.I., and Barbour, A.G. (1985) Transposition of structural genes to an expression sequence on a linear plasmid causes antigenic variation in the bacterium Borrelia hermsii. Nature 318: 257263.
  • 95
    Porcella, S.F., Popova, T.G., Akins, D.R., Li, M., Radolf, J.D., and Norgard, M.V. (1996) Borrelia burgdorferi supercoiled plasmids encode multicopy tandem open reading frames and a lipoprotein gene family. J Bacteriol 178: 32933307.
  • 96
    Postic, D., Ras, N.M., Lane, R.S., Hendson, M., and Baranton, G. (1998) Expanded diversity among Californian borrelia isolates and description of Borrelia bissettii sp. nov. (formerly Borrelia group DN127). J Clin Microbiol 36: 34973504.
  • 97
    Probert, W., and Johnson, B. (1998) Identification of a 47 kd fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31. Mol Microbiol 30: 10031015.
  • 98
    Restrepo, B.I., and Barbour, A.G. (1994) Antigen diversity in the bacterium B. hermsii through ‘somatic’ mutations in rearranged vmp genes. Cell 78: 867876.
  • 99
    Rosa, P.A. (1997) Microbiology of Borrelia burgdorferi. Semin Neurol 17: 510.
  • 100
    Rosa, P.A., Schwan, T., and Hogan, D. (1992) Recombination between genes encoding major outer surface proteins A and B of Borrelia burgdorferi. Mol Microbiol 6: 30313040.
  • 101
    Ryan, J.R., Levine, J.F., Apperson, C.S., Lubke, L., Wirtz, R.A., Spears, P.A., et al (1998) An experimental chain of infection reveals that distinct Borrelia burgdorferi populations are selected in arthropod and mammalian hosts. Mol Microbiol 30: 365379.
  • 102
    Sadziene, A., Rosa, P.A., Thompson, P.A., Hogan, D.M., and Barbour, A.G. (1992) Antibody-resistant mutants of Borrelia burgdorferi : in vitro selection and characterization. J Exp Med 176: 799809.
  • 103
    Sadziene, A., Wilske, B., Ferdows, M.S., and Barbour, A.G. (1993a) The cryptic ospC gene of Borrelia burgdorferi B31 is located on a circular plasmid. Infect Immun 61: 21922195.
  • 104
    Sadziene, A., Barbour, A.G., Rosa, P.A., and Thomas, D.D. (1993b) An OspB mutant of Borrelia burgdorferi has reduced invasiveness in vitro and reduced infectivity in vivo. Infect Immun 61: 35903596.
  • 105
    Salzberg, S.L., Delcher, A.L., Kasif, S., and White, O. (1998) Microbial gene identification using interpolated Markov models. Nucleic Acids Res 26: 544548.
  • 106
    Samuels, D.S., Marconi, R.T., and Garon, C.F. (1993) Variation in the size of the ospA-containing linear plasmid, but not the linear chromosome, among the three Borrelia species associated with Lyme disease. J Gen Microbiol 139: 24452449.
  • 107
    Saunders, N.J., Peden, J.F., Hood, D.W., and Moxon, E.R. (1998) Simple sequence repeats in the Helicobacter pylori genome. Mol Microbiol 27: 10911098.
  • 108
    Schaller, M., and Neubert, U. (1994) Bacteriophages and ultrastructural alterations of Borrelia burgdorferi induced by ciprofloxacin. J Spirochetal Tick Borne Dis 1: 3740.
  • 109
    Schwan, T.G., Burgdorfer, W., and Garon, C.F. (1988) Changes in infectivity and plasmid profile of the Lyme disease spirochete, Borrelia burgdorferi, as a result of in vitro cultivation. Infect Immun 56: 18311836.
  • 110
    Simpson, W.J., Garon, C.F., and Schwan, T.G. (1990a) Analysis of supercoiled circular plasmids in infectious and non-infectious Borrelia burgdorferi. Microb Pathog 8: 109118.
  • 111
    Simpson, W.J., Garon, C.F., and Schwan, T.G. (1990b) Borrelia burgdorferi contains repeated DNA sequences that are species specific and plasmid associated. Infect Immun 58: 847853.
  • 112
    Skamrov, A., Goldman, M., Klasova, J., and Beabealashvilli, R. (1995) Mycoplasma gallisepticum 16S rRNA genes. FEMS Microbiol Lett 128: 321325.DOI: 10.1016/0378-1097(95)00127-q
  • 113
    Skare, J.T., Champion, C.I., Mirzabekov, T.A., Shang, E.S., Blanco, D.R., Erdjument-Bromage, H., et al (1996) Porin activity of the native and recombinant outer membrane protein Oms28 of Borrelia burgdorferi. J Bacteriol 178: 49094918.
  • 114
    Smith, D., Richterich, P., Rubenfield, M., Rice, P., Butler, C., Lee, H., et al (1997) Multiplex sequencing of 1.5 Mb of the Mycobacterium leprae genome. Genome Res 7: 802819.
  • 115
    Stalhammar-Carlemalm, M., Jenny, E., Gern, L., Aeschlimann, A., and Meyer, J. (1990) Plasmid analysis and restriction fragment length polymorphisms of chromosomal DNA allow a distinction between Borrelia burgdorferi strains. Zentralbl Bakteriol 274: 2839.
  • 116
    Stanley, E., Fitzgerald, G.F., Le Marrec, C., Fayard, B., and Van Sinderen, D. (1997) Sequence analysis and characterization of phiO1205, a temperate bacteriophage infecting Streptococcus thermophilus CNRZ1205. Microbiology 143: 34173429.
  • 117
    Steere, A.C., Grodzicki, R.L., Kornblatt, A.N., Craft, J.E., Barbour, A.G., Burgdorfer, W., et al (1983) The spirochetal etiology of Lyme disease. N Engl J Med 308: 733740.
  • 118
    Stevenson, B., and Barthold, S.W. (1994) Expression and sequence of outer surface protein C among North American isolates of Borrelia burgdorferi. FEMS Microbiol Lett 124: 367372.
  • 119
    Stevenson, B., Tilly, K., and Rosa, P.A. (1996) A family of genes located on four separate 32-kilobase circular plasmids in Borrelia burgdorferi B31. J Bacteriol 178: 35083516.
  • 120
    Stevenson, B., Casjens, S., Van Vugt, R., Porcella, S.F., Tilly, K., Bono, J.L., et al (1997) Characterization of cp18, a naturally truncated member of the cp32 family of Borrelia burgdorferi plasmids. J Bacteriol 179: 42854291.
  • 121
    Stevenson, B., Casjens, S., and Rosa, P. (1998a) Evidence of past recombination events among the genes encoding the Erp antigens of Borrelia burgdorferi. Microbiology 144: 18691879.
  • 122
    Stevenson, B., Bono, J.L., Schwan, T.G., and Rosa, P. (1998b) Borrelia burgdorferi Erp proteins are immunogenic in mammals infected by tick bite, and their synthesis is inducible in cultured bacteria. Infect Immun 66: 26482654.
  • 123
    Sueoka, N. (1993) Directional mutation pressure, mutator mutations, and dynamics of molecular evolution. J Mol Evol 37: 137153.
  • 124
    Sutcliffe, I., and Russell, R. (1995) Lipoproteins of Gram-positive bacteria. J Bacteriol 177: 11231128.
  • 125
    Theisen, M. (1996) Molecular cloning and characterization of nlpH, encoding a novel, surface-exposed, polymorphic, plasmid-encoded 33-kilodalton lipoprotein of Borrelia afzelii. J Bacteriol 178: 64356442.
  • 126
    Theisen, M., Frederiksen, B., Lebech, A.M., Vuust, J., and Hansen, K. (1993) Polymorphism in ospC gene of Borrelia burgdorferi and immunoreactivity of OspC protein: implications for taxonomy and for use of OspC protein as a diagnostic antigen. J Clin Microbiol 31: 25702576.
  • 127
    Tilly, K., Casjens, S., Stevenson, B., Bono, J.L., Samuels, D.S., Hogan, D., et al (1997) The Borrelia burgdorferi circular plasmid cp26: conservation of plasmid structure and targeted inactivation of the ospC gene. Mol Microbiol 25: 361373.
  • 128
    Tomb, J.F., White, O., Kerlavage, A.R., Clayton, R.A., Sutton, G.G., Fleischmann, R.D., et al (1997) The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388: 539547.
  • 129
    Walker, D.H. (1998) Tick-transmitted infectious diseases in the United States. Annu Rev Public Health 19: 237269.
  • 130
    Wang, G., Van Dam, A.P., Le Fleche, A., Postic, D., Peter, O., Baranton, G., et al (1997a) Genetic and phenotypic analysis of Borrelia valaisiana sp. nov. (Borrelia genomic groups VS116 and M19). Int J Syst Bacteriol 47: 926932.
  • 131
    Wang, J., Masuzawa, T., Li, M., and Yanagihara, Y. (1997b) Deletion in the genes encoding outer surface proteins OspA and OspB of Borrelia garinii isolated from patients in Japan. Microbiol Immunol 41: 673679.
  • 132
    Wang, G., Van Dam, A.P., Spanjaard, L., and Dankert, J. (1998) Molecular typing of Borrelia burgdorferi sensu lato by randomly amplified polymorphic DNA fingerprinting analysis. J Clin Microbiol 36: 768776.
  • 133
    Will, G., Jauris-Heipke, S., Schwab, E., Busch, U., Rossler, D., Soutschek, E., et al (1995) Sequence analysis of ospA genes shows homogeneity within Borrelia burgdorferi sensu stricto and Borrelia afzelii strains but reveals major subgroups within the Borrelia garinii species. Med Microbiol Immunol (Berl) 184: 7380.
  • 134
    Wilske, B., Jauris-Heipke, S., Lobentanzer, R., Pradel, I., Preac-Mursic, V., Rossler, D., et al (1995) Phenotypic analysis of outer surface protein C (OspC) of Borrelia burgdorferi sensu lato by monoclonal antibodies: relationship to genospecies and OspA serotype. J Clin Microbiol 33: 103109.
  • 135
    Wilske, B., Busch, U., Eiffert, H., Fingerle, V., Pfister, H.W., Rossler, D., et al (1996) Diversity of OspA and OspC among cerebrospinal fluid isolates of Borrelia burgdorferi sensu lato from patients with neuroborreliosis in Germany. Med Microbiol Immunol (Berl) 184: 195201.DOI: 10.1007/s004300050007
  • 136
    Xiang, S.H., Hobbs, M., and Reeves, P.R. (1994) Molecular analysis of the rfb gene cluster of a group D2 Salmonella enterica strain: evidence for its origin from an insertion sequence-mediated recombination event between group E and D1 strains. J Bacteriol 176: 43574365.
  • 137
    Xu, Y., and Johnson, R.C. (1995) Analysis and comparison of plasmid profiles of Borrelia burgdorferi sensu lato strains. J Clin Microbiol 33: 26792685.
  • 138
    Xu, Y., Kodner, C., Coleman, L., and Johnson, R.C. (1996) Correlation of plasmids with infectivity of Borrelia burgdorferi sensu stricto type strain B31. Infect Immun 64: 38703876.
  • 139
    Zhang, J.R., and Norris, S.J. (1998) Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion. Infect Immun 66: 36983704.
  • 140
    Zhang, J.R., Hardham, J.M., Barbour, A.G., and Norris, S.J. (1997) Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes. Cell 89: 275285.
  • 141
    Zhou, X., Cahoon, M., Rosa, P., and Hedstrom, L. (1997) Expression, purification, and characterization of inosine 5′-monophosphate dehydrogenase from Borrelia burgdorferi. J Biol Chem 272: 2197721981.
  • 142
    Zuckert, W.R., and Meyer, J. (1996) Circular and linear plasmids of Lyme disease spirochetes have extensive homology: characterization of a repeated DNA element. J Bacteriol 178: 22872298.
  • 143
    Zuckert, W.R., Meyer, J., and Barbour, A.G. (1999) Comparative analysis and immunological characterization of the Borrelia Bdr protein family. Infect Immun 67: 32573266.