Families of transmembrane sugar transport proteins



  • Milton H. Saier Jr

    Corresponding author
    1. Department of Biology, University of California at San Diego, La Jolla, CA 92093-0116, USA.
    • *For correspondence. E-mail msaier@ucsd.edu; Tel. ( + 1) 858 534 4084; Fax ( + 1) 858 534 7108.

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We describe here 20 families of secondary (pmf-driven) carriers which, in addition to nine families within the ATP-dependent ABC superfamily, and seven families of Gram-negative bacterial outer membrane porins, largely account for the stereospecific transport of sugars and their derivatives into and out of all living cells on earth. Family characteristics as well as struc-tural and functional properties of the family constituents are described. By reference to our website (http://www-biology.ucsd.edu/~msaier/transport/), phylogenetic relationships, detailed substrate specificity information and both primary and secondary references are also available. This review provides a comprehensive guide to the diversity of carriers that mediate the transport of sugar-containing molecules across cell and organellar membranes.