UPs and downs in bacterial transcription initiation: the role of the alpha subunit of RNA polymerase in promoter recognition
Article first published online: 18 JAN 2002
Volume 37, Issue 4, pages 687–695, August 2000
How to Cite
Gourse, R. L., Ross, W. and Gaal, T. (2000), UPs and downs in bacterial transcription initiation: the role of the alpha subunit of RNA polymerase in promoter recognition. Molecular Microbiology, 37: 687–695. doi: 10.1046/j.1365-2958.2000.01972.x
- Issue published online: 18 JAN 2002
- Article first published online: 18 JAN 2002
- Accepted 14 April, 2000.
In recent years, it has become clear that promoter recognition by bacterial RNA polymerase involves interactions not only between core promoter elements and the σ subunit, but also between a DNA element upstream of the core promoter and the α subunit. DNA binding by α can increase transcription dramatically. Here we review the current state of our understanding of the α interaction with DNA during basal transcription initiation (i.e. in the absence of proteins other than RNA polymerase) and activated transcription initiation (i.e. when stimulated by transcription factors).