SEARCH

SEARCH BY CITATION

References

  • Akimaru, J., Matsuyama, S., Tokuda, H., Hiroshima, S. (1991) Reconstitution of a protein translocation system containing purified SecY, SecE, and SecA from Escherichia coli. Proc Natl Acad Sci USA 88: 65456549.
  • Akita, M., Shinkai, A., Matsuyama, S., Mizushima, S. (1991) SecA, an essential component of the secretory machinery of Escherichia coli, exists as homodimer. Biochem Biophys Res Commun 174: 211216.
  • Akiyama, Y. & Ito, K. (1987) Topology analysis of the SecY protein, an integral membrane protein involved in protein export in Escherichia coli. EMBO J 6: 34653470.
  • Arkowitz, R.A. & Wickner, W. (1994) SecD and SecF are required for the proton electrochemical gradient stimulation of preprotein translocation. EMBO J 13: 954963.
  • Baba, T., Taura, T., Shimioke, T., Akiyama, Y., Yoshihisa, T., Ito, K. (1994) A cytoplasmic domain is important for the formation of a SecY–SecE translocator complex. Proc Natl Acad Sci USA 91: 45394543.
  • Bassilana, M. & Wickner, W. (1993) Purified Escherichia coli preprotein translocase catalyses multiple cycles of precursor protein translocation. Biochemistry 32: 26262630.
  • Beck, K., Wu, L.F., Brunner, J., Müller, M. (2000) Discrimination between SRP- and SecA/SecB-dependent substrates involves selective recognition of nascent chains by SRP and trigger factor. EMBO J 19: 134143.
  • Beckmann, R., Bubeck, D., Grassucci, R., Penczek, P., Verschoor, A., Blobel, G., et al. (1997) Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex. Science 278: 21232126.
  • Berks, B.C., Sargent, F., Palmer, T. (2000) The Tat protein export pathway. Mol Microbiol 35: 260274.
  • Bieker, K.L., Phillips, G.J., Silhavy, T.J. (1990) The sec and prl genes of Escherichia coli. J Bioenerg Biomembr 22: 291310.
  • Binet, R., Létoffé, S., Ghigo, J.M., Delepelaire, P., Wandersman, C. (1997) Protein secretion by Gram-negative bacterial ABC transporters — a review. Gene 192: 711.
  • Bost, S. & Belin, D. (1997) prl mutations in the Escherichia coli secG gene. J Biol Chem 272: 40874421.
  • Brundage, L., Hendrick, J.P., Schiebel, E., Driessen, A.J.M., Wickner, W. (1990) The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation. Cell 62: 649657.
  • Cabelli, R.J., Chen, L., Tai, P.C., Oliver, D.B. (1988) SecA protein is required for secretory protein translocation into E. coli membrane vesicles. Cell 55: 683692.
  • Cabelli, R.J., Dolan, K.M., Qian, L., Oliver, D.B. (1991) Characterization of membrane-associated and soluble states of SecA protein from wild-type and SecA51 (TS) mutant strains of Escherichia coli. J Biol Chem 266: 2442024427.
  • Chen, X., Xu, H., Tai, P. (1996) A significant fraction of SecA is permanently embedded in the membrane. J Biol Chem 271: 2868929706.
  • Dalbey, R.E., Lively, M.O., Bron, S., Van Dijl, J.M. (1997) The chemistry and enzymology of the type I signal peptidases. Protein Sci 6: 599604.
  • Danese, P.N. & Silhavy, T. (1998) Targeting and assembly of periplasmic and outer-membrane proteins in Escherichia coli. Annu Rev Genet 32: 5994.
  • De Leeuw, E., Te Kaat, K., Moser, C., Menestrina, G., Demel, R., De Kruijff, B., et al. (2000) Anionic phospholipids are involved in membrane association of FtsY and stimulate its GTPase activity. EMBO J 19: 531541.
  • De Gier, J.-W.L., Valent, Q.A., Von Heijne, G., Luirink, J. (1997) The E. coli SRP: preferences of a targeting factor. FEBS Lett 408: 14.
  • Den Blaauwen, T., Fekkes, P., De Wit, J.G., Kuiper, W., Driessen, A.J.M. (1996) Domain interactions of the peripheral preprotein translocase subunit SecA. Biochemistry 35: 1199412004.
  • Delepelaire, P. & Wandersman, C. (1998) The SecB chaperone is involved in the secretion of the Serratia marcescens HasA protein through an ABC transporter. EMBO J 17: 936944.
  • Derman, A.I., Puziss, J.W., Bassford, P.J., Beckwith, J. (1993) A signal sequence is not required for protein export in prlA mutants of Escherichia coli. EMBO J 12: 879888.
  • De Vrije, T., Tommassen, J., De Kruijff, B. (1987) Optimal posttranslational translocation of the precursor of PhoE protein across Escherichia coli membrane vesicles requires both ATP and the proton motive force. Biochim Biophys Acta 900: 6372.
  • De Vrije, T., Batenburg, A.M., Killian, J.A., De Kruijff, B. (1990) Lipid involvement in protein translocation in Escherichia coli. Mol Microbiol 4: 143150.
  • Douville, K., Leonard, M., Brundage, L., Nishiyama, K.-I., Tokuda, H., Mizushima, S., et al. (1993) Band 1 subunit of Escherichia coli preprotein translocase and integral membrane export factor p12 are the same protein. J Biol Chem 269: 1870518707.
  • Douville, K., Price, A., Eichler, J., Economou, T., Wickner, W. (1995) SecYEG and SecA are the stoichiometric components of preprotein translocase. J Biol Chem 270: 2010620111.
  • Driessen, A.J.M. (1992) Precursor protein translocation by the Escherichia coli translocase is directed by the proton motive force. EMBO J 11: 847853.
  • Driessen, A.J.M. (1993) SecA, the peripheral subunit of the Escherichia coli precursor protein translocase, is functional as a dimer. Biochemistry 32: 1319013197.
  • Driessen, A.J.M. (1994) How proteins cross the bacterial cytoplasmic membrane. J Membr Biol 142: 145159.
  • Driessen, A.J.M., Fekkes, P., Van der Wolk, J.P.W. (1998) The Sec system. Curr Opin Microbiol 1: 216222.
  • Duong, F. & Wickner, W. (1997a) Distinct catalytic roles of the SecYE, SecG and SecDFyajC subunits of preprotein translocase holoenzyme. EMBO J 19: 27562768.
  • Duong, F. & Wickner, W. (1997b) The SecDFyajC domain of preprotein translocase controls preprotein movement by regulating SecA membrane cycling. EMBO J 16: 48714879.
  • Duong, F. & Wickner, W. (1998) Sec-dependent membrane protein biogenesis: SecYEG, preprotein hydrophobicity and translocation kinetics control the stop-transfer function. EMBO J 17: 696705.
  • Duong, F. & Wickner, W. (1999) The PrlA and PrlG phenotypes are caused by a loosened association among the translocase SecYEG subunits. EMBO J 18: 32633270.
  • Duong, F., Eichler, J., Price, A., Rice Leonard, M., Wickner, W. (1997) Biogenesis of the Gram-negative bacterial envelope. Cell 91: 567573.
  • Economou, A. & Wickner, W. (1994) SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion. Cell 78: 835843.
  • Economou, A., Pogliano, J.A., Beckwith, J., Oliver, D.B., Wickner, W. (1995) SecA membrane cycling at SecYEG is driven by distinct ATP binding and hydrolysis events and is regulated by SecD and SecF. Cell 83: 11711181.
  • Eichler, J. & Wickner, W. (1997) Both an N-terminal 65-kDa domain and a C-terminal 30-kDa domain of SecA cycle into the membrane at SecYEG during translocation. Proc Natl Acad Sci USA 94: 55745581.
  • Eichler, J. & Wickner, W. (1998) The SecA subunit of Escherichia coli preprotein translocase is exposed to the periplasm. J Bacteriol 180: 57765779.
  • Eichler, J., Brunner, J., Wickner, W. (1997) The protease-protected 30 kDa domain of SecA is largely inaccessible to the membrane lipid phase. EMBO J 16: 21882196.
  • Erdmann, R., Veenhuis, M., Kunau, W. (1997) Peroxisomes: organelles at the cross-roads. Trends Cell Biol 7: 400407.
  • Fekkes, P. & Driessen, A.J.M. (1999) Protein targeting to the bacterial cytoplasmic membrane. Microbiol Mol Biol Rev 63: 161173.
  • Fekkes, P., De Wit, J.G., Van der Walk, J.P.W., Kimsey, H.H., Kumamoto, C.A., Driessen, A.J.M. (1998) Preprotein transfer to the Escherichia coli translocase requires the cooperative binding of SecB and the signal sequence to SecA. Mol Microbiol 29: 11791190.
  • Fekkes, P., Van der Does, C., Driessen, A.J.M. (1997) The molecular chaperone SecB is released from the carboxy-terminus of SecA during initiation of precursor protein translocation. EMBO J 16: 61056113.
  • Flower, A.M., Doebele, R.C., Silhavy, T.J. (1994) PrlA and PrlG suppressors reduce the requirement for signal sequence recognition. J Bacteriol 176: 56075614.
  • Flower, A.M., Osborne, R., Silhavy, T.J. (1995) The allele-specific synthetic lethality of prlA-prlG double mutants predicts interactive domains of SecY and SecE. EMBO J 14: 884893.
  • Gardel, C., Benson, S., Hunt, J., Michaelis, S., Beckwith, J. (1987) secD, a new gene involved in protein export in E. coli. J Bacteriol 169: 12861290.
  • Gardel, C., Johnson, K., Jacq, A., Beckwith, J. (1990) The secD locus of E. coli codes for two membrane proteins required for protein export. EMBO J 9: 32093216.
  • Geller, B.L., Movva, N.R., Wickner, W. (1986) Both ATP and the electrochemical potential are required for optimal assembly of proOmpA into Escherichia coli inner membrane vesicles. Proc Natl Acad USA 83: 42194222.
  • Görlich, D. & Mattaj, I.W. (1996) Nucleocytoplasmic transport. Science 271: 15131518.
  • Görlich, D. & Rapoport, T.A. (1993) Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum. Cell 75: 615630.
  • Hamman, B.D., Chen, J.-C., Johnson, E.E., Johnson, A.E. (1997) The aqueous pore through the translocon has a diameter of 40–60 Å during cotranslational protein translocation at the ER membrane. Cell 89: 535544.
  • Hamman, B.D., Hendershot, L.M., Johnson, A.E. (1998) BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation. Cell 92: 747758.
  • Hanada, M., Nishiyama, K., Mizushima, S., Tokuda, H. (1994) Reconstitution of an efficient protein translocation machinery comprising SecA and the three membrane proteins, SecY, SecE, and SecG (p12). J Biol Chem 269: 2362523631.
  • Hanein, D., Matlack, K.E.S., Jungnickel, B., Plath, K., Kalies, K.-U., Miller, K.R., et al. (1996) Oligomeric rings of the Sec61 complex induced by ligands required for protein translocation. Cell 87: 721732.
  • Harris, C.R. & Silhavy, T.J. (1999) Mapping an interface of SecY (PrlA) and SecE (PrlG) by using synthetic phenotypes and in vivo cross-linking. J Bacteriol 181: 34383444.
  • Hartl, F.-U., Lecker, S., Schiebel, E., Hendrick, J.P., Wickner, W. (1990) The binding cascade of SecB to SecA to SecY/E mediates preprotein targeting to the E. coli plasma membrane. Cell 63: 269279.
  • Hartmann, E., Sommer, T., Prehn, S., Gorlich, D., Jentsch, S., Rapoport, T.A. (1994) Evolutionary conservation of the components of the protein translocation complex. Nature 367: 654657.
  • Heins, L. & Soll, J. (1998) Chloroplast biogenesis: mixing the eukaryotic and the prokaryotic? Curr Biol 8: 215217.
  • Hell, K., Herrmann, J.M., Pratje, E., Neupert, W., Stuart, R.A. (1998) Oxa1p, an essential component of the N-tail protein export machinery in mitochondria. Proc Natl Acad Sci USA 95: 22502255.
  • Hirano, M., Matsuyama, S., Tokuda, H. (1996) The carboxyl-terminal region is essential for SecA dimerization. Biochem Biophys Res Commun 229: 9095.
  • Homma, T., Yoshihisa, T., Ito, K. (1997) Subunit interactions in the Escherichia coli protein translocase: SecE and SecG associate independently with SecY. FEBS Lett 408: 1115.
  • Hueck, C.J. (1998) Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiol Mol Biol Rev 62: 379433.
  • Jarosik, G.P. & Oliver, D.B. (1991) Isolation and analysis of dominant secA mutations in Escherichia coli. J Bacteriol 173: 860868.
  • Joly, J.C. & Wickner, W. (1993) The SecA and SecY subunits of translocase are the nearest neighbors of a translocating preprotein, shielding it from phospholipids. EMBO J 12: 255263.
  • Joly, J.C., Leonard, M., Wickner, W. (1994) Subunit dynamics in Escherichia coli preprotein translocase. Proc Natl Acad Sci USA 91: 47034707.
  • Karamanou, S., Vrontou, E., Sianidis, G., Baud, C., Roos, T., Kuhn, A., et al. (1999) A molecular switch in SecA protein couples ATP hydrolysis to protein translocation. Mol Microbiol 34: 11331145.
  • Kaufmann, A., Manting, E.H., Veenendaal, A.K., Driessen, A.J.M., Van Der Does, C. (1999) Cysteine-directed cross-linking demonstrates that helix 3 of SecE is close to helix 2 of SecY and helix 3 of a neighboring SecE. Biochemistry 38: 91159125.
  • Kawasaki, S., Mizushima, S., Tokuda, H. (1993) Membrane vesicles containing overproduced SecY and SecE exhibit high translocation ATPase activity and countermovement of protons in a SecA- and presecretory protein-dependent manner. J Biol Chem 268: 81938198.
  • Keller, R.C.A., Ten Berge, D., Nouwen, N., Snel, M.M.E., Tommassen, J., Marsh, D., et al. (1996) Mode of insertion of the signal sequence of a bacterial precursor protein into phospholipid bilayers as revealed by cysteine-based site-directed spectroscopy. Biochemistry 35: 30633071.
  • Kihara, A., Akiyama, Y., Ito, K. (1995) FtsH is required for proteolytic elimination of uncomplexed forms of SecY, and essential protein translocase subunit. Proc Natl Acad Sci USA 92: 45324536.
  • Kim, Y.J., Rajapandi, T., Oliver, D.B. (1994) SecA protein is exposed to the periplasmic surface of the E. coli inner membrane in its active state. Cell 78: 845853.
  • Kimura, E., Akita, M., Matsuyama, K., Mizushima, S. (1991) Determination of a region in SecA that interacts with presecretory proteins in Escherichia coli. J Biol Chem 266: 66006606.
  • Koch, H.G., Hengelage, T., Neumann-Haefelin, C., MacFarlane, J., Hoffschulte, H.K., Schimz, K.L., et al. (1999) In vitro studies with purified components reveal signal recognition particle (SRP) and SecA/SecB as constituents of two independent protein-targeting pathways of Escherichia coli. Mol Biol Cell 10: 21632173.
  • Kumamoto, C.A. (1991) Molecular chaperones and protein translocation across the Escherichia coli inner membrane. Mol Microbiol 5: 1922.
  • Lang, B.F., Burger, G., O'Kelly, C.J., Cedergren, R., Golding, G.B., Lemieux, C., et al. (1997) An ancestral mitochondrial DNA resembling a eubacterial genome in miniature. Nature 387: 493497.
  • Lill, R., Dowham, W., Wickner, W. (1990) The ATPase activity of SecA is regulated by acidic phospholipids, SecY, and the leader and mature domains of precursor proteins. Cell 60: 271280.
  • Luirink, J., High, S., Wood, H., Giner, A., Tollervey, D., Dobberstein, B. (1992) Signal sequence recognition by an Escherichia coli ribonucleoprotein complex. Nature 359: 741743.
  • Luirink, J., Ten Hagen-Jongman, C.M., Van der Weijden, C.C., Oudega, B., High, S., Dobberstein, B., et al. (1994) An alternative protein targeting pathway in Escherichia coli: studies on the role of FtsY. EMBO J 13: 22892296.
  • Manting, E.H., Van Der Does, C., Driessen, A.J.M. (1997) In vivo cross-linking of the SecA and SecY subunits of the Escherichia coli preprotein translocase. J Bacteriol 179: 56995704.
  • Manting, E.H., Kaufmann, A., Van Der Does, C., Driessen, A.J.M. (1999) A single amino acid substitution in SecY stabilizes the interaction with SecA. J Biol Chem 274: 2386823874.
  • Manting, E.H., Van Der Does, C., Remigy, H., Engel, A., Driessen, A.J.M. (2000) SecYEG assembles into a tetramer to form the active protein translocation channel. EMBO J 19: 852861.
  • Matsumoto, G., Yoshihisa, T., Ito, K. (1997) SecY and SecA interact to allow SecA insertion and protein translocation across the Escherichia coli plasma membrane. EMBO J 16: 63846393.
  • Matsuyama, S., Fujita, Y., Mizushima, S. (1993) SecD is involved in the release of translocated secretory proteins from the cytoplasmic membrane of Escherichia coli. EMBO J 12: 265270.
  • Meyer, T.H., Ménétret, J.-F., Breitling, R., Miller, K.R., Akey, C.W., Rapoport, T.A. (1999) The bacterial SecY/E translocation complex forms channel-like structures similar to those of the eukaryotic Sec61p complex. J Mol Biol 285: 17891800.
  • Mitchell, C. & Oliver, D.B. (1993) Two distinct ATP-binding domains are needed to promote protein export by Escherichia coli SecA ATPase. Mol Microbiol 10: 483497.
  • Moore, M., Harrison, M.S., Peterson, E.C., Henry, R. (2000) Chloroplast Oxa1p homolog Albino3 is required for post-translational integration of the light-harvesting chlorophyll-binding protein into thylakoid membranes. J Biol Chem 275: 15291532.
  • Murphy, C.K. & Beckwith, J. (1994) Residues essential for the function of SecE, a membrane component of the Escherichia coli secretion apparatus, are located in a conserved cytoplasmic region. Proc Natl Acad Sci USA 91: 25572560.
  • Neupert, W. (1997) Protein import into mitochondria. Annu Rev Biochem 66: 863917.
  • Nishiyama, K.-I., Mizushima, S., Tokuda, H. (1993) A novel membrane protein involved in protein translocation across the cytoplasmic membrane of Escherichia coli. EMBO J 12: 34093415.
  • Nishiyama, K.-I., Suzuki, T., Tokuda, H. (1996) Inversion of the membrane topology of SecG coupled with SecA-dependent preprotein translocation. Cell 85: 7181.
  • Nishiyama, K.-I., Fukuda, A., Morita, K., Tokuda, H. (1999) Membrane-deinsertion of SecA underlying proton motive force-dependent stimulation of protein translocation. EMBO J 18: 10491058.
  • Nouwen, N., De Kruijff, B., Tommassen, J. (1996a) ΔμH+ dependency of in vitro protein translocation into E. coli inner membrane vesicles varies with the signal sequence core region composition. Mol Microbiol 19: 12051214.
  • Nouwen, N., De Kruijff, B., Tommassen, J. (1996b) prlA suppressors in Escherichia coli relieve the proton electrochemical dependency of translocation of wild-type precursors. Proc Natl Acad Sci USA 93: 59535957.
  • Palade, G. (1975) Intracellular aspects of the process of protein secretion. Science 189: 347358.
  • Panzner, S., Dreier, L., Hartmann, E., Kostka, S., Rapoport, T.A. (1995) Post-translational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p. Cell 81: 561570.
  • Park, S., Liu, G., Topping, T.B., Cover, W.H., Randall, L.L. (1988) Modulation of the folding pathway of exported proteins by the leader sequence. Science 239: 10331035.
  • Phillips, G.J. & Silhavy, T.J. (1992) The E. coli ffh gene is necessary for viability and efficient protein export. Nature 359: 744746.
  • Pogliano, K.J. & Beckwith, J. (1994) Genetic and molecular characterization of the Escherichia coli secD operon and its products. J Bacteriol 176: 804814.
  • Pohlschröder, M., Murphy, C., Beckwith, J. (1996) In vivo analyses of interactions between SecE and SecY, core components of the Escherichia coli protein translocation machinery. J Biol Chem 271: 1990819914.
  • Pohlschröder, M., Prinz, W.A., Hartmann, E., Beckwith, J. (1997) Protein translocation in the three domains of life: variations on a theme. Cell 91: 563566.
  • Poritz, M.A., Strub, K., Walter, P. (1988) Human SRP RNA and E. coli 4.5S RNA contain a highly homologous structural domain. Cell 55: 46.
  • Powers, T. & Walter, P. (1997) Co-translational protein targeting catalyzed by the Escherichia coli signal sequence recognition particle and its receptor. EMBO J 16: 48804886.
  • Price, A., Economou, A., Duong, F., Wickner, W. (1996) Separable ATPase and membrane insertion domains of the SecA subunit of preprotein translocase. J Biol Chem 271: 3158031584.
  • Prinz, W.A., Spiess, C., Ehrmann, M., Schierle, C., Beckwith, J. (1996) Targeting of signal sequence less proteins for export in Escherichia coli with altered protein translocase. EMBO J 15: 52095217.
  • Prinz, A., Behrens, C., Rapoport, T.A., Hartmann, E., Kalies, K.-U. (2000) Evolutionarily conserved binding of ribosomes to the translocation channel via the large ribosomal RNA. EMBO J 19: 19001906.
  • Pugsley, A.P. (1993) The complete general secretory pathway in Gram-negative bacteria. Microbiol Rev 57: 50108.
  • Qi, H.-Y. & Bernstein, H.D. (1999) SecA is required for the insertion of inner membrane proteins targeted by the Escherichia coli signal sequence recognition particle. J Biol Chem 274: 89938997.
  • Rajapandi, T. & Oliver, D. (1996) Integration of SecA protein into the Escherichia coli inner membrane is regulated by its amino-terminal ATP-binding domain. Mol Microbiol 20: 4351.
  • Ramamurthy, V. & Oliver, D.B. (1997) Topology of the integral membrane form of Escherichia coli SecA protein reveals multiple periplasmically exposed regions and modulation by ATP binding. J Biol Chem 272: 2323923246.
  • Randall, L.L. & Hardy, S.J.S. (1989) Unity in the absence of consensus in the sequence: role of leader peptides in export. Science 243: 11561159.
  • Rapoport, T.A., Jungnickel, B., Kutay, U. (1996) Protein translocation across the eukaryotic endoplasmic reticulum membrane and bacterial inner membranes. Annu Rev Biochem 65: 271303.
  • Römisch, K., Webb, J., Herz, J., Prehn, S., Frank, R., Vogron, M., et al. (1989) Homology of the 54K protein of signal-sequence recognition particle, docking protein and two E. coli proteins with putative GTP-binding domains. Nature 340: 478482.
  • Rothman, J.E. & Wieland, F.T. (1994) Protein sorting by transport vesicles. Science 272: 227234.
  • Sato, K., Mori, H., Yoshida, M., Tagaya, M., Mizushima, S. (1997a) Short hydrophobic segments in the mature domain of proOmpA determine its stepwise movement during translocation across the cytoplasmic membrane of Escherichia coli. J Biol Chem 272: 58805886.
  • Sato, K., Mori, H., Yoshida, M., Tagaya, M., Mizushima, S. (1997b) In vitro analysis of the stop-transfer process during translocation across the cytoplasmic membrane of Escherichia coli. J Biol Chem 272: 2008220087.
  • Schatz, P.J., Bieker, K.L., Ottemann, K.M., Silhavy, T.J., Beckwith, J. (1991) One of three transmembrane stretches is sufficient for the functioning of the SecE protein, a membrane component of the E. coli secretion machinery. EMBO J 10: 17491757.
  • Schatz, G. (1996) The protein import system of mitochondria. J Biol Chem 271: 3176331766.
  • Schatz, G. & Dobberstein, B. (1996) Common principles of protein translocation across membranes. Science 271: 15191526.
  • Schatz, P.J. & Beckwith, J. (1990) Genetic analysis of protein export in Escherichia coli. Annu Rev Genet 24: 215248.
  • Schekman, R. & Orci, L. (1996) Coat proteins and vesicle budding. Science 271: 15261533.
  • Schiebel, E., Driessen, A.J.M., Hartl, F.-U., Wickner, W. (1991) ΔμH+ and ATP function at different steps of the catalytic cycle of preprotein translocase. Cell 64: 927939.
  • Schmidt, M., Haiyuan, D., Ramamurthy, V., Mukerji, I., Oliver, D. (2000) Nucleotide binding activity of SecA homodimer is conformationally regulated by temperature and altered by prlD and azi mutations. J Biol Chem 275: 1544015448 .
  • Schnell, D. (1995) Shedding light on the chloroplast protein import machinery. Cell 83: 521524.
  • Scotti, P.A., Valent, Q.A., Manting, E.H., Urbanus, M.L., Driessen, A.J.M., Oudega, B., et al. (1999) SecA is not required for signal recognition particle-mediated targeting and initial membrane insertion of a nascent inner membrane protein. J Biol Chem 274: 2988329888.
  • Scotti, P.A., Urbanus, M.L., Brunner, J., De Gier, J.-W.L., Von Heijne, G., Van Der Does, C., et al. (2000) YidC, the E. coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase. EMBO J 19: 542549.
  • Settles, A.M. & Martiensen, R. (1998) Old and new pathways of protein export in chloroplasts and bacteria. Trends Cell Biol 8: 494501.
  • Shilton, B., Svergun, D.I., Volkov, V.V., Koch, M.I.J., Cusack, S., Economou, A. (1998) Escherichia coli SecA shape and dimensions. FEBS Lett 436: 277282.
  • Shiozuka, K., Tani, K., Mizushima, S., Tokuda, H. (1990) The proton motive force lowers the level of ATP required for the in vitro translocation of a secretory protein in Escherichia coli. J Biol Chem 265: 1884318847.
  • Simon, S.M. & Blobel, G. (1992) Signal peptides open protein-conducting channels in E. coli. Cell 69: 677684.
  • Snyders, S., Ramamurhty, V., Oliver, D.B. (1997) Identification of a region of interaction between Escherichia coli SecA and SecY proteins. J Biol Chem 272: 1130211306.
  • Subramani, S. (1996) Protein translocation into peroxisomes. J Biol Chem 271: 3248332486.
  • Suzuki, H., Nishiyama, K.-I., Tokuda, H. (1998) Coupled structure change of SecA and SecG revealed by the synthetic lethality of the secAcsR11 and ΔsecG::kan double mutant. Mol Microbiol 29: 331341.
  • Tani, K., Shiozuka, K., Tokuda, H., Mizushima, S. (1989) In vitro analysis of the process of translocation of OmpA across the Escherichia coli cytoplasmic membrane. J Biol Chem 264: 1858218588.
  • Tani, K., Tokuda, H., Mizushima, S. (1990) Translocation of proOmpA possessing an intramolecular disulphide bridge into membrane vesicles of Escherichia coli. J Biol Chem 265: 1734117347.
  • Taura, T., Baba, T., Akiyama, Y., Ito, K. (1993) Determinants of the quantity of the stable SecY complex in the Escherichia coli cell. J Bacteriol 175: 7717775.
  • Taura, T., Yoshihisa, T., Ito, K. (1997) Protein translocation functions of Escherichia coli SecY: in vitro characterization of cold-sensitive secY mutants. Biochimie 79: 517521.
  • Uchida, K., Mori, H., Mizushima, S. (1995) Stepwise movement of preproteins in the process of translocation across the cytoplasmic membrane of Escherichia coli. J Biol Chem 270: 3086230868.
  • Ulbrandt, N.D., Newitt, J.A., Bernstein, H. (1997) The E. coli signal sequence recognition particle is required for the insertion of a subset of inner membrane proteins. Cell 88: 187196.
  • Valent, Q.A., Kendall, D.A., High, S., Kusters, R., Oudega, B., Luirink, J. (1995) Early events in preprotein recognition in E. coli: interactions of SRP and trigger factor with nascent polypeptides. EMBO J 14: 54945505.
  • Valent, Q.A., De Gier, J.-W.L., Von Heijne, G., Kendall, D.A., Ten Hagen-Jongman, C.M., Oudega, B., et al. (1997) Nascent membrane and presecretory proteins synthesised in Escherichia coli associate with signal sequence recognition particle and trigger factor. Mol Microbiol 25: 189197.
  • Valent, Q.A., Scotti, P.A., High, S., De Gier, J.-W.L., Von Heijne, G., Lentzen, G., et al. (1998) The Escherichia coli SRP and SecB targeting pathways converge at the translocon. EMBO J 17: 25042512.
  • Van Dalen, A., Killian, A., De Kruijff, B. (1999) ΔμH+ stimulates membrane translocation of the C-terminal part of a signal sequence. J Biol Chem 274: 1991319918.
  • Van der Does, C., Den Blaauwen, T., De Wit, J.G., Manting, E.H., Groot, N., Fekkes, P., et al. (1996) SecA is an intrinsic subunit of the Escherichia coli preprotein translocase and exposes its carboxy-terminus to the periplasm. Mol Microbiol 22: 619629.
  • Van der Does, C., Manting, E.H., Kaufmann, A., Lutz, M., Driessen, A.J.M. (1998) Interaction between SecA and SecYEG in micellar solution and formation of the membrane-inserted state. Biochemistry 37: 201210.
  • Van der Wolk, J.P.W., Boorsma, A., Knoche, M., Schäfer, H.-J., Driessen, A.J.M. (1997a) The low affinity ATP-binding site of the Escherichia coli SecA dimer is localized at the subunit interface. Biochemistry 36: 1492414929.
  • Van der Wolk, J.P.W., De Wit, J.G., Driessen, A.J.M. (1997b) The catalytic cycle of the Escherichia coli SecA ATPase comprises two distinct preprotein translocation events. EMBO J 16: 72977304.
  • Van der Wolk, J.P.W., Fekkes, P., Boorsma, A., Huie, J.L., Silhavy, T.J., Driessen, A.J.M. (1998) PrlA4 prevents the rejection of signal sequence defective preproteins by stabilizing the SecA–SecY interaction during the initiation of translocation. EMBO J 17: 36313639.
  • Van Voorst, F., Van der Does, C., Brunner, J., Driessen, A.J.M., De Kruijff, B. (1998) Translocase-bound SecA is largely shielded from the phospholipid acyl chains. Biochemistry 37: 1226112268.
  • Van Wely, K.H.M., Swaving, J., Broekhuizen, C.P., Rose, M., Quax, W.J., Driessen, A.J.M. (1999) Functional identification of the product of the Bacillus subtilis yvaL gene as a SecG homologue. J Bacteriol 181: 17861792.
  • Von Heijne, G. (1990) The signal peptide. J Membr Biol 115: 195201.
  • Von Heijne, G. (1994) Membrane proteins: from sequence to structure. Annu Rev Biophys Biomol Struct 23: 167192.
  • Von Heijne, G. (1997) Getting greasy: how transmembrane polypeptide segments integrate into the lipid bilayer. Mol Microbiol 24: 249253.
  • Walker, J.E., Saraste, M., Runswick, M.J., Gay, N.J. (1982) Distantly related sequences in the α- and β-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes have a common nucleotide binding fold. EMBO J 1: 945951.
  • Walter, P. & Johnson, A.E. (1994) Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane. Annu Rev Cell Biol 10: 87119.
  • Walter, P. & Lingapper, V.R. (1986) Mechanism of protein translocation across the endoplasmic reticulum membrane. Ann Rev Cell Biol 2: 499516.
  • Wickner, W., Driessen, A.J.M., Hartl, F.-U. (1991) The enzymology of protein translocation across the Escherichia coli plasma membrane. Annu Rev Biochem 60: 101124.
  • Yamada, H., Matsuyama, S., Tokuda, H., Mizushima, S. (1989) A high concentration of SecA allows proton motive force-independent translocation of a model secretory protein into Escherichia coli membrane vesicles. J Biol Chem 264: 1857718581.
  • Yamane, K., Ichihara, S., Mizushima, S. (1987) In vitro translocation of protein across Escherichia coli membrane vesicles requires both the proton motive force and ATP. J Biol Chem 262: 23582362.
  • Yuan, J. & Cline, K. (1994) SecA homolog in protein transport within chloroplast: evidence for endosymbiont-derived sorting. Science 266: 796798.