The phenylacetyl-CoA catabolon: a complex catabolic unit with broad biotechnological applications
Article first published online: 7 JUL 2008
Volume 39, Issue 6, pages 1434–1442, March 2001
How to Cite
Luengo, J. M., García, J. L. and Olivera, E. R. (2001), The phenylacetyl-CoA catabolon: a complex catabolic unit with broad biotechnological applications. Molecular Microbiology, 39: 1434–1442. doi: 10.1046/j.1365-2958.2001.02344.x
- Issue published online: 7 JUL 2008
- Article first published online: 7 JUL 2008
- Accepted 5 January, 2001.
The term catabolon was introduced to define a complex functional unit integrated by different catabolic pathways, which are, or could be, co-ordinately regulated, and that catalyses the transformation of structurally related compounds into a common catabolite. The phenylacetyl-CoA catabolon encompasses all the routes involved in the transformation of styrene, 2-phenylethylamine, trans-styrylacetic acid, phenylacetaldehyde, phenylacetic acid, phenylacetyl amides, phenylacetyl esters and n-phenylalkanoic acids containing an even number of carbon atoms, into phenylacetyl-CoA. This common intermediate is subsequently catabolized through a route of convergence, the phenylacetyl-CoA catabolon core, into general metabolites. The genetic organization of this central route, the biochemical significance of the whole functional unit and its broad biotechnological applications are discussed.