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  • Baca , A.M. , Sirawaraporn , R. , Turley , S. , Sirawaraporn , W. , and Hol , W.G. ( 2000 ) Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action . J Mol Biol 302 : 11931212 .
  • Banerjee , A. , Dubnau , E. , Quemard , A. , Balasubramanian , V. , Um , K.S. , Wilson , T. , et al. ( 1994 ) inhA , a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis . Science 263 : 227230 .
  • Banerjee , A. , Sugantino , M. , Sacchettini , J.C. , and Jacobs , W.R. ( 1998 ) The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance . Microbiology 144 : 26972704 .
  • Barry , C.E. , III ( 1997 ) New horizons in the treatment of tuberculosis . Biochem Pharmacol 54 : 11651172 .
  • Barry , C.E. ( 2001 ) Mycobacterium smegmatis : an absurd model for tuberculosis? Trends Microbiol 9 : 473474 .
  • Basso , L.A. , Zheng , R. , Musser , J.M. , Jacobs , W.R. , and Blanchard , J.S. ( 1998 ) Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates . J Infect Dis 178 : 769775 .
  • Baulard , A.R. , Betts , J.C. , Engohang-Ndong , J. , Quan , S. , McAdam , R.A. , Brennan , P.J. , et al. ( 2000 ) Activation of the pro-drug ethionamide is regulated in mycobacteria . J Biol Chem 275 : 2832628331 .
  • Bernstein , J.W. , Lott , W.A. , Steinberg , B.A. , and Yale , H.L. ( 1952 ) Chemotherapy of experimental tuberculosis . Am Rev Tuberc 65 : 357374 .
  • Davies , R.W. , and Gronenborn , A.M. ( 1982 ) Molecular cloning of the gene for dihydrofolate reductase from Lactobacillus casei . Gene 17 : 229233 .
  • DeBarber , A.E. , Mdluli , K. , Bosman , M. , Bekker , L.G. , and Barry , C.E. , III ( 2000 ) Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis . Proc Natl Acad Sci USA 97 : 96779682 .
  • Dessen , A. , Quemard , A. , Blanchard , J.S. , Jacobs , W.R. , and Sacchettini , J.C. ( 1995 ) Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis . Science 267 : 16381641 .
  • Donnelly-Wu , M.K. , Jacobs , W.R. , Jr , and Hatfull , G.F. ( 1993 ) Superinfection immunity of mycobacteriophage L5: applications for genetic transformation of mycobacteria . Mol Microbiol 7 : 407417 .
  • Dubnau , E. , Fontan , P. , Manganelli , R. , Soares-Appel , S. , and Smith , I. ( 2002 ) Mycobacterium tuberculosis genes induced during infection of human macrophages. Infect Immun 70 : 27872795 .
  • Duncan , K. , and Sacchettini , J.C. ( 2000 ) Approaches to tuberculosis drug development . In Molecular Genetics of Mycobacteria . Hatfull , G.F. , and Jacobs , W.R. (eds) . Washington, DC : American Society for Microbiology Press , pp. 297312 .
  • Fox , H.H. ( 1952 ) The chemical approach to the control of tuberculosis . Science 116 : 129134 .
  • Gold , B. , Rodriquez , R. , Marras , S. , Pentecost , M. , and Smith , I. ( 2001 ) The Mycobacterium tuberculosis IdeR is a dual functional regulator that controls transcription of genes involved in iron acquisition, iron storage, and survival in macrophages . Mol Microbiol 42 : 851865 .
  • Hampele , I.C. , D’Arcy , A. , Dale , G.E. , Kostrewa , D. , Nielsen , J. , Oefner , C. , et al. ( 1997 ) Structure and function of the dihydropteroate synthase from Staphylococcus aureus . J Mol Biol 268 : 2130 .
  • Heifets , L.B. ( 1991 ) Drug Susceptibility in the Chemotherapy of Mycobacterial Infections . Boston : CRC Press .
  • Heym , B. , Honore , N. , Truffot-Pernot , C. , Banerjee , A. , Schurra , C. , Jacobs , W.R. , et al. ( 1994 ) Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: a molecular study . Lancet 344 : 293298 .
  • Johnsson , K. , and Schultz , P.G. ( 1994 ) Mechanistics studies of the oxidation of isoniazid by the catalase peroxidase from Mycobacterium tuberculosis . J Am Chem Soc 116 : 74257426 .
  • Kiepiela , P. , Bishop , K. , Smith , A.N. , Roux , L. , and York , D.F. ( 2000 ) Genomic mutations in the katG, inhA and aphC genes are useful for the prediction of isoniazid resistance in Mycobacterium tuberculosis isolates from Kwazulu Natal, South Africa . Tubercle Lung Dis 80 : 4756 .
  • Kikuchi , S. , Rainwater , D.L. , and Kolattukudy , P.E. ( 1992 ) Purification and characterization of an unusually large fatty acid synthase from Mycobacterium tuberculosis var. bovis BCG . Arch Biochem Biophys 295 : 318326 .
  • Kremer , L. , Douglas , J.D. , Baulard , A.R. , Morehouse , C. , Guy , M.R. , Alland , D. , et al. ( 2000 ) Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis . J Biol Chem 275 : 1685716864 .
  • Lee , A.S. , Lim , I.H. , Tang , L.L. , Telenti , A. , and Wong , S.Y. ( 1999 ) Contribution of kasA analysis to detection of isoniazid-resistant Mycobacterium tuberculosis. Singapore . Antimicrob Agents Chemother 43 : 20872089 .
  • Lee , A.S. , Teo , A.S. , and Wong , S.Y. ( 2001 ) Novel mutations in ndh in isoniazid-resistant Mycobacterium tuberculosis isolates . Antimicrob Agents Chemother 45 : 21572159 .
  • Leszczynska , K. , Bolhuis , A. , Leenhouts , K. , Venema , G. , and Ceglowski , P. ( 1995 ) Cloning and molecular analysis of the dihydrofolate reductase gene from Lactococcus lactis . Appl Environ Microbiol 61 : 561566 .
  • Li , R. , Sirawaraporn , R. , Chitnumsub , P. , Sirawaraporn , W. , Wooden , J. , Athappilly , F. , et al. ( 2000 ) Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs . J Mol Biol 295 : 307323 .
  • Manganelli , R. , Dubnau , E. , Tyagi , S. , Kramer , F.R. , and Smith , I. ( 1999 ) Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis . Mol Microbiol 31 : 715724 .
  • Mdluli , K. , Sherman , D.R. , Hickey , M.J. , Kreiswirth , B.N. , Morris , S. , Stover , C.K. , and Barry , C.E. ( 1996 ) Biochemical and genetic data suggest that InhA is not the primary target for activated isoniazid in Mycobacterium tuberculosis . J Infect Dis 174 : 10851090 .
  • Mdluli , K. , Slayden , R.A. , Zhu , Y. , Ramaswamy , S. , Pan , X. , Mead , D. , et al. ( 1998 ) Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid . Science 280 : 16071610 .
  • Nagate , T. , Inoue , M. , Inoue , K. , and Mitsuhashi , S. ( 1978 ) Plasmid-mediated sulfanilamide resistance . Microbiol Immunol 22 : 367375 .
  • O'Brien , K.L. , Dietz , H.C. , Romagnoli , M. , and Eiden , J. ( 1996 ) Evaluation of inhA gene and catalase-peroxidase gene among isoniazid-sensitive and resistant Mycobacterium tuberculosis isolates . Mol Cell Probes 10 : 16 .
  • Peterson , D.O. , and Bloch , K. ( 1977 ) Mycobacterium smegmatis fatty acid synthetase. Long chain transacylase chain length specificity . J Biol Chem 252 : 57355739 .
  • Piatek , A.S. , Telenti , A. , Murray , M.R. , El-Hajj , H. , Jacobs , W.R. , Jr, Kramer , F.R. , and Alland , D. ( 2000 ) Genotypic analysis of Mycobacterium tuberculosis. two distinct populations using molecular beacons: implications for rapid susceptibility testing . Antimicrob Agents Chemother 44 : 103110 .
  • Quemard , A. , Sacchettini , J.C. , Dessen , A. , Vilcheze , C. , Bittman , R. , Jacobs , W.R. , and Blanchard , J.S. ( 1995 ) Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis . Biochemistry 34 : 82358241 .
  • Quemard , A. , Dessen , A. , Sugantino , M. , Jacobs , W.R. , Sacchettini , J.C. , and Blanchard , J.S. ( 1996 ) Binding of catalase-peroxidase activated isoniazid to wild-type and mutant Mycobacterium tuberculosis enoyl-ACP reductases . J Am Chem Soc 118 : 15611562 .
  • Ristow , M. , Mohlig , M. , Rifai , M. , Schatz , H. , Feldmann , K. , and Pfeiffer , A. ( 1995 ) New isoniazid/ethionamide resistance gene mutation and screening for multidrug-resistant Mycobacterium tuberculosis strains . Lancet 346 : 502503 .
  • Rock , C.O. , and Cronan , J.E. ( 1996 ) Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis . Biochim Biophys Acta 1302 : 116 .
  • Rouse , D.A. , Li , Z. , Bai , G.H. , and Morris , S.L. ( 1995 ) Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis . Antimicrob Agents Chemother 39 : 24722477 .
  • Rozwarski , D.A. , Grant , G.A. , Barton , D.H. , Jacobs , W.R. , and Sacchettini , J.C. ( 1998 ) Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis . Science 279 : 98102 .
  • Schimke , R.T. , Kaufman , R.J. , Alt , F.W. , and Kellems , R.F. ( 1978 ) Gene amplification and drug resistance in cultured murine cells . Science 202 : 10511055 .
  • Skold , O. ( 1976 ) R-factor-mediated resistance to sulfonamides by a plasmid-borne, drug-resistant dihydropteroate synthase . Antimicrob Agents Chemother 9 : 4954 .
  • Slayden , R.A. , and Barry , C.E. , III ( 2000 ) The genetics and biochemistry of isoniazid resistance in Mycobacterium tuberculosis . Microbes Infect 2 : 659669 .
  • Slayden , R.A. , Lee , R.E. , Armour , J.W. , Cooper , A.M. , Orme , I.M. , Brennan , P.J. , and Besra , G.S. ( 1996 ) Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis . Antimicrob Agents Chemother 40 : 28132819 .
  • Slayden , R.A. , Lee , R.E. , and Barry , C.E. ( 2000 ) Isoniazid affects multiple components of the type II fatty acid synthase system of Mycobacterium tuberculosis . Mol Microbiol 38 : 514525 .
  • Smith , D.R. , Rood , J.I. , Bird , P.I. , Sneddon , M.K. , Calvo , J.M. , and Morrison , J.F. ( 1982 ) Amplification and modification of dihydrofolate reductase in Escherichia coli. Nucleotide sequence of fol genes from mutationally altered plasmids . J Biol Chem 257 : 90439048 .
  • Snapper , S.B. , Lugosi , L. , Jekkel , A. , Melton , R.E. , Kieser , T. , Bloom , B.R. , and Jacobs , W.R. , Jr ( 1988 ) Lysogeny and transformation in mycobacteria: stable expression of foreign genes . Proc Natl Acad Sci USA 85 : 69876991 .
  • Snapper , S.B. , Melton , R.E. , Mustafa , S. , Kieser , T. , and Jacobs , W.R. , Jr ( 1990 ) Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis . Mol Microbiol 4 : 19111919 .
  • Stover , C.K. , de la Cruz , V.F. , Fuerst , T.R. , Burlein , J.E. , Benson , L.A. , Bennett , L.T. , et al. ( 1991 ) New use of BCG for recombinant vaccines . Nature 351 : 456460 .
  • Swedberg , G. , Castensson , S. , and Skold , O. ( 1979 ) Characterization of mutationally altered dihydropteroate synthase and its ability to form a sulfonamide-containing dihydrofolate analog . J Bacteriol 137 : 129136 .
  • Takayama , K. , Wang , L. , and David , H.L. ( 1972 ) Effect of isoniazid on the in vivo mycolic acid synthesis, cell growth, and viability of Mycobacterium tuberculosis . Antimicrob Agents Chemother 2 : 2935 .
  • Takayama , K. , Schnoes , H.K. , Armstrong , E.L. , and Boyle , R.W. ( 1975 ) Site of inhibitory action of isoniazid in the synthesis of mycolic acids in Mycobacterium tuberculosis . J Lipid Res 16 : 308317 .
  • Telenti , A. , Honore , N. , Bernasconi , C. , March , J. , Ortega , A. , Heym , B. , et al. ( 1997 ) Genotypic assessment of isoniazid and rifampin resistance in Mycobacterium tuberculosis: a blind study at reference laboratory level . J Clin Microbiol 35 : 719723 .
  • Vilcheze , C. , Morbidoni , H.R. , Weisbrod , T.R. , Iwamoto , H. , Kuo , M. , Sacchettini , J.C. , and Jacobs , W.R. ( 2000 ) Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis . J Bacteriol 182 : 40594067 .
  • Wilson , T.M. , de Lisle , G.W. , and Collins , D.M. ( 1995 ) Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis . Mol Microbiol 15 : 10091015 .
  • Wilson , M. , DeRisi , J. , Kristensen , H.H. , Imboden , P. , Rane , S. , Brown , P.O. , and Schoolnik , G.K. ( 1999 ) Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization . Proc Natl Acad Sci USA 96 : 1283312838 .
  • Winder , F.G. , and Collins , P.B. ( 1970 ) Inhibition by isoniazid of synthesis of mycolic acids in Mycobacterium tuberculosis . J Gen Microbiol 63 : 4148 .
  • Wise , E.M. , Jr , and Abou-Donia , M.M. ( 1975 ) Sulfonamide resistance mechanism in Escherichia coli: R plasmids can determine sulfonamide-resistant dihydropteroate synthases . Proc Natl Acad Sci USA 72 : 26212625 .
  • Zhang , Y. , Heym , B. , Allen , B. , Young , D. , and Cole , S. ( 1992 ) The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis . Nature 358 : 591593 .
  • Zhang , Y. , Garbe , T. , and Young , D. ( 1993 ) Transformation with katG restores isoniazid-sensitivity in Mycobacterium tuberculosis isolates resistant to a range of drug concentrations . Mol Microbiol 8 : 521524 .