• 1
    Cheever AW, Deb S, Duvall RH. Granuloma formation in Schistosoma japonicum infected nude mice: the effects of reconstitution with L3T4+ or Lyt2+ splenic cells. Am J Trop Med Hyg 1989; 40: 6671.
  • 2
    Mathew RC & Boros DL. Anti-L3T4 antibody treatment suppresses hepatic granuloma formation and abrogates antigen-induced interleukin-2 production in Schistosoma mansoni infection. Infect Immun 1986; 54: 820826.
  • 3
    Kopf M, Le-Gros G, Bachmann M, Lamers MC, Bluethmann H, Kohler G. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 1993; 362: 245248.
  • 4
    Wang ZE, Reiner SL, Zheng S, Dalton KK, Locksley RM. CD4+ effector cells default to the Th2 pathway in interferon-γ deficient mice infected with Leishmania major. J Exp Med 1994; 179: 13671371.
  • 5
    Grzych JM, Pearce E, Cheever AW et al. Egg deposition is the major stimulus for the production of Th2 cytokines in murine Schistosomiasis mansoni. J Immunol 1991; 146: 13221327.
  • 6
    Flores-Villanueva PO, Zheng XX, Strom TB, Stadecker MJ. Recombinant IL-10 and IL-10/Fc treatment down-regulate egg antigen-specific delayed hypersensitivity reactions and egg granuloma formation in schistosomiasis. J Immunol 1996; 156: 33153320.
  • 7
    Stadecker MJ & Hernandez HJ. The immune response and immunopathology in infection with Schistosoma mansoni: a key role of major egg antigen Sm-p40. Parasite Immunol 1998; 20: 217221.
  • 8
    Chiaramonte MG, Donaldson DD, Cheever AW, Wynn TA. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest 1999; 104: 777785.
  • 9
    Chiaramonte MG, Schopf LR, Neben TY, Cheever AW, Donaldson DD, Wynn TA. IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs. J Immunol 1999; 162: 920930.
  • 10
    McKenzie GJ, Fallon PG, Emson CL, Grencis RK, McKenzie AN. Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. J Exp Med 1999; 189: 15651572.
  • 11
    Cheever AW, Xu YH, Sher A, Macedonia JG. Analysis of egg granuloma formation in Schistosoma japonicum-infected mice treated with antibodies to interleukin-5 and gamma interferon. Infect Immun 1991; 59: 40714074.
  • 12
    Chensue SW, Warmington KS, Ruth J, Lincoln PM, Kunkel SL. Cross-regulatory role of interferon-gamma (IFN-gamma), IL-4 and IL-10 in schistosome egg granuloma formation: in vivo regulation of Th activity and inflammation. Clin Exp Immunol 1994; 98: 395400.
  • 13
    Wynn TA, Eltoum I, Oswald IP, Cheever AW, Sher A. Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology. J Exp Med 1994; 179: 15511561.
  • 14
    Chensue SW, Warmington KS, Ruth J, Lincoln P, Kunkel SL. Cytokine function during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation. Local and regional participation of IFN-gamma, IL-10, and TNF. J Immunol 1995; 154: 59695976.
  • 15
    Akhiani AA, Lycke N, Nilsson LA, Olling S, Ouchterlony O. Lack of interferon-gamma receptor does not influence the outcome of infection in murine Schistosomiasis mansoni. Scand J Immunol 1996; 43: 257262.
  • 16
    Lortat Jacob H, Baltzer F, Desmouliere A, Peyrol S, Grimaud JA. Lobular − but not periovular − inhibition of collagen deposition in the liver of S. mansoni infected mice using interferon-gamma. J Hepatol 1997; 26: 894903.
  • 17
    Rezende SA, Oliveira VR, Silva AM, Alves JB, Goes AM, Reis LF. Mice lacking the gamma interferon receptor have an impaired granulomatous reaction to Schistosoma mansoni infection. Infect Immun 1997; 65: 34573461.
  • 18
    Yap G, Cheever AW, Caspar P, Jankovic D, Sher A. Unimpaired down-modulation of the hepatic granulomatous response in CD8 T-cell- and gamma interferon-deficient mice chronically infected with Schistosoma mansoni. Infect Immun 1997; 65: 25832586.
  • 19
    Cheever AW, Williams ME, Wynn TA et al. Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis. J Immunol 1994; 153: 753759.
  • 20
    Pearce EJ, Cheever AW, Leonard S et al. IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile. J Immunol 1999; 163: 337342.
  • 21
    Cheever AW, Finkelman FD, Cox TM. Anti-interleukin-4 treatment diminishes secretion of Th2 cytokines and inhibits hepatic fibrosis in murine Schistosomiasis japonica. Parasite Immunol 1995; 17: 103109.
  • 22
    Hirata M, Takushima M, Kage M, Fukuma T. Induction of experimental murine granuloma formation against Schistosoma japonicum eggs produced by in vitro ova deposition, in vitro tissue extraction, or lyophilization. Parasitol Res 1991; 77: 315319.
  • 23
    Sunderkotter C, Beil W, Roth J, Sorg C. Cellular events associated with inflammatory angiogenesis in the mouse cornea. Am J Pathol 1991; 138: 931939.
  • 24
    Reichert CM, Rosenstein M, Von Glatz J, Hsu SM, Rosenberg SA. Curative intravenous adoptive immunotherapy of Meth A murine sarcoma. A histologic and immunohistochemical assessment. Lab Invest 1985; 52: 304313.
  • 25
    Hirata M, Nakashima T, Fukuma T. Characteristics of eosinophilic inclusions within Schistosoma japonicum eggs. Parasitology 1999; 118: 269274.
  • 26
    Lu B, Rutledge BJ, Gu L et al. Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med 1998; 187: 601608.
  • 27
    Brunet LR, Finkelman FD, Cheever AW, Kopf MA, Pearce EJ. IL-4 protects against TNF-α-mediated cachexia and death during acute schistosomiasis. J Immunol 1997; 159: 777785.
  • 28
    Sher A, Coffman RL, Hieny S, Scott P, Cheever AW. Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni. Proc Natl Acad Sci USA 1990; 87: 6165.
  • 29
    Zurawski G & De Vries JE. Interleukin 13, and interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol Today 1994; 15: 1926.
  • 30
    Kaplan MH, Whitfield JR, Boros DL, Grusby MJ. Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response. J Immunol 1998; 160: 18501856.
  • 31
    Hoffmann KF, James SL, Cheever AW, Wynn TA. Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni. J Immunol 1999; 163: 927938.
  • 32
    Wynn TA, Morawetz R, Scharton Kersten T et al. Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo. J Immunol 1997; 159: 50145023.