• 1
    Boros DL, Warren KS. Delayed hypersensitivity-type granuloma formation and dermal reaction induced and elicited by a soluble factor isolated from Schistosoma mansoni eggs. J Exp Med 1970; 132: 488507.
  • 2
    Warren KS. A functional classification of granulomatous inflammation. Ann NY Acad Sci 1976; 278: 718.
  • 3
    Boros DL. T helper cell populations, cytokine dynamics, and pathology of the schistosome egg granuloma. Microbes Infect 1999; 1: 511516.
  • 4
    Sher A, Coffman RL, Hieny S, Scott P, Cheever AW. Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni. Proc Natl Acad Sci USA 1990; 87: 6165.
  • 5
    Chensue SW, Terebuh PD, Warmington KS et al. Role of IL-4 and IFN-gamma in Schistosoma mansoni egg-induced hypersensitivity granuloma formation. Orchestration, relative contribution, and relationship to macrophage function. J Immunol 1992; 148: 900906.
  • 6
    Vella AT, Hulsebosch MD, Pearce EJ. Schistosoma mansoni eggs induce antigen-responsive CD44-hi T helper 2 cells and IL-4-secreting CD44-lo cells. Potential for T helper 2 subset differentiation is evident at the precursor level. J Immunol 1992; 149: 17141722.
  • 7
    Cheever AW, Williams ME, Wynn TA et al. Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis. J Immunol 1994; 153: 753759.
  • 8
    Chensue SW, Warmington KS, Ruth J, Lincoln PM, Kunkel SL. Cross-regulatory role of interferon-gamma (IFN-gamma), IL-4 and IL-10 in schistosome egg granuloma formation: in vivo regulation of Th activity and inflammation. Clin Exp Immunol 1994; 98: 395400.
  • 9
    Kaplan MH, Whitfield JR, Boros DL, Grusby MJ. Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response. J Immunol 1998; 160: 18501856.
  • 10
    Chiaramonte MG, Schopf LR, Neben TY, Cheever AW, Donaldson DD, Wynn TA. IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs. J Immunol 1999; 162: 920930.
  • 11
    McKenzie GJ, Fallon PG, Emson CL, Grencis RK, McKenzie AN. Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. J Exp Med 1999; 189: 15651572.
  • 12
    Pearce EJ, La Flamme A, Sabin E, Brunet LR. The initiation and function of Th2 responses during infection with Schistosoma mansoni. Adv Exp Med Biol 1998; 452: 6773.
  • 13
    Chiaramonte MG, Donaldson DD, Cheever AW, Wynn TA. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest 1999; 104: 777785.
  • 14
    Zlotnik A, Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity 2000; 12: 121127.
  • 15
    Rossi D, Zlotnik A. The biology of chemokines and their receptors. Annu Rev Immunol 2000; 18: 217242.
  • 16
    Keane MP, Strieter RM. Chemokine signaling in inflammation. Crit Care Med 2000; 28: N13N26.
  • 17
    Loetscher P, Seitz M, Baggiolini M, Moser B. Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes. J Exp Med 1996; 184: 569577.
  • 18
    Bonecchi R, Polentarutti N, Luini W et al. Up-regulation of CCR1 and CCR3 and induction of chemotaxis to CC chemokines by IFN-gamma in human neutrophils. J Immunol 1999; 162: 474479.
  • 19
    Chensue SW, Warmington KS, Ruth JH, Lincoln P, Kunkel SL. Cytokine function during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation. Local and regional participation of IFN-gamma, IL-10, and TNF. J Immunol 1995; 154: 59695976.
  • 20
    Chensue SW, Warmington K, Ruth J, Lincoln P, Kuo MC, Kunkel SL. Cytokine responses during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation. Production of Th1 and Th2 cytokines and relative contribution of tumor necrosis factor. Am J Pathol 1994; 145: 11051113.
  • 21
    Qiu B, Frait KA, Reich F, Komuniecki E, Chensue SW. Chemokine expression dynamics in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation. Am J Pathol 2001; 158: 15031515.
  • 22
    Park MK, Hoffmann KF, Cheever AW, Amichay D, Wynn TA, Farber JM. Patterns of chemokine expression in models of Schistosoma mansoni inflammation and infection reveal relationships between type 1 and type 2 responses and chemokines in vivo. Infect Immun 2001; 69: 67556768.
  • 23
    Shang X, Qiu B, Frait KA et al. Chemokine receptor 1 knockout abrogates natural killer cell recruitment and impairs type-1 cytokines in lymphoid tissue during pulmonary granuloma formation. Am J Pathol 2000; 157: 20552063.
  • 24
    Katschke KJ Jr, Rottman JB, Ruth JH et al. Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis. Arthritis Rheum 2001; 44: 10221032.
  • 25
    Sarafi MN, Garcia-Zepeda EA, MacLean JA, Charo IF, Luster AD. Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. J Exp Med 1997; 185: 99109.
  • 26
    D’Ambrosio D, Iellem A, Bonecchi R et al. Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. J Immunol 1998; 161: 51115115.
  • 27
    Sallusto F, Kremmer E, Palermo B et al. Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells. Eur J Immunol 1999; 29: 20372045.
  • 28
    Campbell JD, HayGlass KT. T cell chemokine receptor expression in human Th1- and Th2-associated diseases. Arch Immunol Ther Exp (Warsz) 2000; 48: 451456.
  • 29
    Panina-Bordignon P, Papi A, Mariani M et al. The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J Clin Invest 2001; 107: 13571364.
  • 30
    Inngjerdingen M, Damaj B, Maghazachi AA. Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309. J Immunol 2000; 164: 40484054.
  • 31
    Haque NS, Fallon JT, Taubman MB, Harpel PC. The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein (a)-stimulated endothelial cell conditioned medium. Blood 2001; 97: 3945.
  • 32
    Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O. The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. J Biol Chem 1997; 272: 1503615042.
  • 33
    Bernardini G, Hedrick J, Sozzani S et al. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. Eur J Immunol 1998; 28: 582588.
  • 34
    Yoneyama H, Harada A, Imai T et al. Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice. J Clin Invest 1998; 102: 19331941.
  • 35
    Caux C, Ait-Yahia S, Chemin K et al. Dendritic cell biology and regulation of dendritic cell trafficking by chemokines. Springer Semin Immunopathol 2000; 22: 345369.
  • 36
    Bowman EP, Campbell JJ, Soler D et al. Developmental switches in chemokine response profiles during B cell differentiation and maturation. J Exp Med 2000; 191: 13031318.
  • 37
    Fitzhugh DJ, Naik S, Caughman SW, Hwang ST. Cutting edge: C-C chemokine receptor 6 is essential for arrest of a subset of memory T cells on activated dermal microvascular endothelial cells under physiologic flow conditions in vitro. J Immunol 2000; 165: 66776681.
  • 38
    Yamashiro S, Wang JM, Yang D, Gong WH, Kamohara H, Yoshimura T. Expression of CCR6 and CD83 by cytokine-activated human neutrophils. Blood 2000; 96: 39583963.
  • 39
    Cyster JG. Leukocyte migration: scent of the T zone. Curr Biol 2000; 10: R30R33.
  • 40
    Sallusto F, Mackay CR, Lanzavecchia A. The role of chemokine receptors in primary, effector, and memory immune responses. Annu Rev Immunol 2000; 18: 593620.
  • 41
    Chensue SW, Warmington K, Ruth JH, Lukacs N, Kunkel SL. Mycobacterial and schistosomal antigen-elicited granuloma formation in IFN-gamma and IL-4 knockout mice: analysis of local and regional cytokine and chemokine networks. J Immunol 1997; 159: 35653573.
  • 42
    Ruth JH, Warmington KS, Shang X et al. Interleukin-4 and -13 participation in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation: multiparameter analysis of cellular recruitment, chemokine expression and cytokine networks. Cytokine 2000; 12: 432444.
  • 43
    Warmington KS, Boring L, Ruth JH et al. Effect of C-C chemokine receptor 2 (CCR2) knockout on type-2 (schistosomal antigen-elicited) pulmonary granuloma formation: analysis of cellular recruitment and cytokine responses. Am J Pathol 1999; 154: 14071416.
  • 44
    Chensue SW, Lukacs NW, Yang TY, et al. Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. J Exp Med 2001; 193: 573584.
  • 45
    Zingoni A, Soto H, Hedrick JA et al. The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells. J Immunol 1998; 161: 547551.
  • 46
    Napolitano M, Santoni A. Structure and function of the CC chemokine receptor (CCR) 8. Forum 1999; 9: 315324.
  • 47
    Sallusto F, Palermo B, Hoy A, Lanzavecchia A. The role of chemokine receptors in directing traffic of naive, type 1 and type 2 T cells. Curr Top Microbiol Immunol 1999; 246: 123129.