• 1
    Fatkenheuer G, Taelman H, Lepage P, Schwenk A, Wenzel R. The return of tuberculosis. Diag Microbiol Infect Dis 1999;34:139.
  • 2
    Bonecini-Almeida MG, Chital S, Biutsikakis I, et al. Induction of in vitro human macrophage anti-Mycobacterium tuberculosis activity: requirement for IFN-γ and primed lymphocytes. J Immunol 1998;160:44904499.
  • 3
    Orme IM, Roberts AD, Griffin JP, Abrams JS. Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection. J Immunol 1993;151:518525.
  • 4
    Caruso AM, Serbina N, Klein E, Triebold K, Bloom BR, Flynn JL. Mice deficient in CD4 T cells have only transiently diminished levels of IFN-γ, yet succumb to tuberculosis. J Immunol 1999;162:54075416.
  • 5
    Tascon RE, Stavropoulos E, Lukacs KV, Colston MJ. Protection against Mycobacterium tuberculosis infection by CD8+ T cells requires the production of gamma interferon. Infect Immun 1998;66:830834.
  • 6
    Bonato VLD, Lima VMF, Tascon RE, Lowrie DB, Silva CL. Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosis-infected mice. Infect Immun 1998;66:169.
  • 7
    Flynn JL, Goldstein MM, Chan J, et al. Tumor necrosis factor alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 1995;2:561572.
  • 8
    Cooper AM, Magram J, Ferrante J, Orme IM. Cytokine 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis. J Exp Med 1997;186:3945.
  • 9
    Cooper AM, Dalton DK, Stewart TA, Griffin JP, Russel DG, Orme IM. Disseminated tuberculosis in interferon γ gene-disrupted mice. J Exp Med 1993;178:22432247.
  • 10
    Flynn JL, Chan J, Triebold KJ, Dalton DK, Stewart TA, Bloom BR. An essential role for interferon γ in resistance to Mycobacterium tuberculosis infection. J Exp Med 1993;178:22492254.
  • 11
    Edwards D & Kirkpatrick C. The immunology of mycobacterial diseases. Am Rev Respir Dis 1996;134:1062.
  • 12
    Flesch I & Kaufmann S. Mechanisms involved in mycobacterial growth inhibition by gamma-interferon activated bone marrow macrophages: role of reactive nitrogen intermediates. Infect Immun 1995;59:3213.
  • 13
    Chan J, Tanaka K, Carrol D, Flynn J, Bloom BR. Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis. Infect Immun 1995;63:736740.
  • 14
    Silva CL & Lowrie DB. identification and characterization of murine cytotoxic T cells that kill Mycobacterium tuberculosis. Infect Immun 2000;68:32693274.
  • 15
    Serbina NV, Liu CC, Scanga CA, Flynn JL. CD8+ CTL from lungs of Mycobacterium tuberculosis-infected mice express perforin in vivo and lyse infected macrophages. J Immunol 2000;165:353363.
  • 16
    Flynn JL & Ernst JD. Immune responses in tuberculosis. Curr Opin Immunol 2000;12:432436.
  • 17
    Mueller DL, Jenkins MK, Schwartz RH. Clonal expansion versus functional clonal inactivation: a costimulatory signaling pathway determines the outcome of T cell antigen receptor occupancy. Annu Rev Immunol 1989;7:445480.
  • 18
    Freeman GJ, Borrelo F, Hodes RJ, et al. Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science 1993;262:907909.
  • 19
    Freeman GJ, Borriello F, Hodes RJ, et al. Murine B7–2, an alternative CTLA-4 counter-receptor that costimulates T cell proliferation and cytokine 2 production. J Exp Med 1993;178:21852192.
  • 20
    Harding FA, McArthur JG, Gross JA, Raulet DH, Allison JP. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 1992;356:607609.
  • 21
    Boussiotis VA, Gribben JG, Freeman GJ, Nadler LM. Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance. Curr Opin Immunol 1994;6:797807.
  • 22
    Gross JA, Callas E, Allison JP. Identification and distribution of the costimulatory receptor CD28 in the mouse. J Immunol 1992;149:380388.
  • 23
    Gimmi CD, Freeman GJ, Gribben JG, et al. cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete cytokine-2. Proc Natl Acad Sci USA 1991;88:65756579.
  • 24
    Reiser H, Freeman GJ, Razi-Wolf Z, Gimmi CD, Benacerraf B, Nadler LM. Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex. Proc Natl Acad Sci USA 1992;89:271275.
  • 25
    Linsley OS, Brady W, Urnes M, Grosmarie LS, Damle NK, Ledbetter JA. CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med 1991;174:561.
  • 26
    Linsley OS, Greene JL, Tan P, et al. Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J Exp Med 1992;176:1595.
  • 27
    Chambers CA, Krummel MF, Boitel B, et al. The role of CTLA-4 in the regulation and initiation of T-cell responses. Immunol Rev 1996;153:2746.
  • 28
    Damle NK, Klussman K, Linsley PS, Aruffo A. Differential costimulatory effects of adhesion molecules B7, ICAM-1, LFA-3 and VCAM-1 on resting and antigen-primed CD4+ T lymphocytes. J Immunol 1992;148:19851992.
  • 29
    Sato T, Tachibana K, Nojima Y, D'Avirro N, Morimoto C. Role of the VLA-4 molecule in T cell costimulation. J Immunol 1995;155:29382947.
  • 30
    Springer TA. Adhesion receptors of the immune system. Nature 1990;346:425434.
  • 31
    Wülfing C & Davis MM. A receptor/cytoskeletal movement triggered by costimulation during T cell activation. Science 1998;282:2266.
  • 32
    Viola A, Schroeder S, Sakakibara Y, Lanzavecchia A. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 1999;283:680682.DOI: 10.1126/science.283.5402.680
  • 33
    McDonough KA & Kress Y. Cytotoxicity for lung epithelial cells is a virulence associated phenotype of Mycobacterium tuberculosis. Infect Immun 1995;63:48024811.
  • 34
    Lenschow DJ, Walunas TL, Bluestone JA. CD28/B7 system of T cell costimulation. Ann Rev Immunol 1996;14:233.
  • 35
    Lenschow DJ, Su GH-T, Zuckerman LA, et al. Expression and functional significance of an additional ligant for CTLA-4. Proc Natl Acad Sci USA 1993;90:1105411058.
  • 36
    Azuma M, Ito D, Yagita H, et al. B70 antigen is a second ligant for CTLA-4 and CD28. Nature 1993;366:7679.
  • 37
    Hathcock KS, Laszlo G, Pucillo C, Linsley P, Hodes RJ. Comparative analysis of B7–1 and B7–2 costimulatory ligants: expression and function. J Exp Med 1994;180:631.
  • 38
    Lenschow DJ, Sperling AI, Cooke MP, et al. Differential up-regulation of the B7–1 and B7–2 costimulatory molecules after Ig receptor engagement by antigen. J Immunol 1994;153:19901997.
  • 39
    June CH, Bluestone JA, Nadler LE, Thompson CB. The B7 and CD28 receptors families. Immunol Today 1994;15:321331.
  • 40
    Saha B, Das G, Vohra H, Ganguly NK, Mishra GC. Macrophage – T cell interaction in experimental mycobacterial infection. Selective regulation of co-stimulatory molecules on Mycobacterium-infected macrophages and its implication in the supression of T cell-mediated immune response. Eur J Immunol 1994;24:26182624.
  • 41
    Kaye PM, Roggers NJ, Curry AJ, Scott JC. Deficient expression of costimulatory molecules on Leishmania-infected macrophages. Eur J Immunol 1994;24:28502854.
  • 42
    Subauste CS, De Waal Malefyt R, Fuh F. Role of CD80 (B7.1) and CD86 (B7.2) in the immune response to an intracellular pathogen. J Immunol 1998;160:18311840.
  • 43
    Schlesinger LS. Macrophage phagocytosis of virulent but not attenuated strains of Mycobacterium tuberculosis is mediated by mannose receptors in addition to complement receptors. J Immunol 1993;150:29202930.
  • 44
    Hetland G & Wiker HG. Antigen 85C on Mycobacterium bovis, BCG and M. tuberculosis promotes monocyte-CR3-mediated uptake of microbeads coated with mycobacterial products. Immunol 1994;82:445.
  • 45
    Hu C, Mayadas-Norton T, Tanaka K, Chan J, Salgame P. Mycobacterium tuberculosis infection in complement receptor 3-deficient mice. J Immunol 2000;165:25962602.
  • 46
    Chuang E, Alegre ML, Duckett CS, et al. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligant-independent endocytosis that limits cell surface expression. J Immunol 1997;159:144151.
  • 47
    Hogg N & Landis RC. Adhesion molecules in cell interactions. Curr Opin Immunol 1993;5:383390.
  • 48
    Sánchez-Mateos P, Campanero MR, Balboa MA, Sánchez-Madrid F. Co-clustering of β1 integrins, cytoskeletal proteins, and tyrosine-phosphorylated substrates during integrin-mediated leukocyte aggregation. J Immunol 1993;151:38173828.
  • 49
    Murray PJ & Young RA. Increased antimycobacterial immunity in cytokine-10 deficient mice. Infect Immun 1999;67:3087.