• 1
    Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994;76: 30114.
  • 2
    Sallusto F et al. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999;401: 70812.
  • 3
    Westermann J, Engelhardt B, Hoffmann JC. Migration of T cells in vivo: molecular mechanisms and clinical implications. Ann Intern Med 2001;135: 27995.
  • 4
    Kehrl JH et al. Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med 1986;163: 103750.
  • 5
    Sad S, Mosmann TR. Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype. J Immunol 1994;153: 351422.
  • 6
    Swain SL et al. Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype. J Immunol 1991;147: 29913000.
  • 7
    Ludviksson BR et al. The effect of TGF-beta1 on immune responses of naive versus memory CD4+ Th1/Th2 T cells. Eur J Immunol 2000;30: 210111.
  • 8
    Heath VL et al. TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression. Eur J Immunol 2000;30: 263949.
  • 9
    Ranges GE et al. Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha. J Exp Med 1987;166: 9918.
  • 10
    Lee HM, Rich S. Differential activation of CD8+ T cells by transforming growth factor-beta 1. J Immunol 1993;151: 66877.
  • 11
    Genestier L et al. Transforming growth factor beta1 inhibits Fas ligand expression and subsequent activation-induced cell death in T cells via downregulation of c-Myc. J Exp Med 1999;189: 2319.
  • 12
    Cerwenka A et al. Fas- and activation-induced apoptosis are reduced in human T cells preactivated in the presence of TGF-beta 1. J Immunol 1996;156: 45964.
  • 13
    Cerwenka A et al. TGF-beta 1 is a potent inducer of human effector T cells. J Immunol 1994;153: 436777.
  • 14
    Horwitz DA, Gray JD, Zheng SG. The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases. Arthritis Res 2002;4: 2416.
  • 15
    Groux H et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997;389: 73742.
  • 16
    Weiner HL. Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells. Microbes Infect 2001;3: 94754.
  • 17
    Shevach EM. Certified professionals: CD4(+)CD25(+) suppressor T cells. J Exp Med 2001;193: F416.
  • 18
    Thornton AM, Shevach EM. Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol 2000;164: 18390.
  • 19
    Levings MK, Sangregorio R, Roncarolo MG. Human CD25(+)CD4(+) T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001;193: 1295302.
  • 20
    Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med 2001;194: 62944.
  • 21
    Stephens LA et al. Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur J Immunol 2001;31: 124754.
  • 22
    Dieckmann D et al. Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J Exp Med 2001;193: 130310.
  • 23
    Suri-Payer E, Cantor H. Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+) CD25(+) T cells. J Autoimmun 2001;16: 11523.
  • 24
    Piccirillo CA et al. CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J Exp Med 2002;196: 23746.
  • 25
    Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299: 105761.
  • 26
    Massague J. The transforming growth factor-beta family. Annu Rev Cell Biol 1990;6: 597641.
  • 27
    Letterio JJ, Roberts AB. Transforming growth factor-beta1-deficient mice: identification of isoform-specific activities in vivo. J Leukoc Biol 1996;59: 76974.
  • 28
    Roberts AB, Sporn MB. Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta). Growth Factors 1993;8: 19.
  • 29
    McCartney-Francis NL, Wahl SM. Transforming growth factor beta: a matter of life and death. J Leukoc Biol 1994;55: 4019.
  • 30
    Sporn MB et al. Some recent advances in the chemistry and biology of transforming growth factor-beta. J Cell Biol 1987;105: 103945.
  • 31
    Randolph GJ et al. The CD16(+) (FcgammaRIII(+)) subset of human monocytes preferentially becomes migratory dendritic cells in a model tissue setting. J Exp Med 2002;196: 51727.
  • 32
    Adams DH et al. Transforming growth factor-beta induces human T lymphocyte migration in vitro. J Immunol 1991;147: 60912.
  • 33
    Wahl SM et al. Transforming growth factor type beta induces monocyte chemotaxis and growth factor production. Proc Natl Acad Sci USA 1987;84: 578892.
  • 34
    Fan K et al. Transforming growth factor-beta 1 bifunctionally regulates murine macrophage proliferation. Blood 1992;79: 167985.
  • 35
    McCartney-Francis N et al. TGF-beta regulates production of growth factors and TGF-beta by human peripheral blood monocytes. Growth Factors 1990;4: 2735.
  • 36
    Murakozy G et al. Gene polymorphisms of immunoregulatory cytokines and angiotensin-converting enzyme in Wegener's granulomatosis. J Mol Med 2001;79: 66570.
  • 37
    Strober W, Ludviksson BR, Fuss IJ. The pathogenesis of mucosal inflammation in murine models of inflammatory bowel disease and Crohn's disease. Ann Intern Med 1998;128: 84856.
  • 38
    Weyand CM et al. Correlation of the topographical arrangement and the functional pattern of tissue-infiltrating macrophages in giant cell arteritis. J Clin Invest 1996;98: 16429.
  • 39
    Ludviksson BR et al. Administration of mAb against alpha E beta 7 prevents and ameliorates immunization-induced colitis in IL-2-/- mice. J Immunol 1999;162: 497582.
  • 40
    Cheon H et al. Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-beta1 in synovial fibroblasts from rheumatoid arthritis and normal individuals. Clin Exp Immunol 2002;127: 54752.
  • 41
    Fava RA et al. Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia. J Exp Med 1991;173: 112132.
  • 42
    Berse B et al. Hypoxia augments cytokine (transforming growth factor-beta (TGF-beta) and IL-1)-induced vascular endothelial growth factor secretion by human synovial fibroblasts. Clin Exp Immunol 1999;115: 17682.
  • 43
    Massague J. TGF-beta signal transduction. Annu Rev Biochem 1998;67: 75391.
  • 44
    Cottrez F, Groux H. Regulation of TGF-beta response during T cell activation is modulated by IL-10. J Immunol 2001;167: 7738.
  • 45
    Massague J. How cells read TGF-beta signals. Nat Rev Mol Cell Biol 2000;1: 16978.
  • 46
    Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 1995;270: 164836.
  • 47
    Xiao YQ et al. Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta. J Biol Chem 2002;277: 1488493.
  • 48
    Sallusto F et al. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med 1998;187: 87583.
  • 49
    Franitza S et al. TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules. Eur J Immunol 2002;32: 193202.
  • 50
    Bleul CC et al. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Natl Acad Sci USA 1997;94: 192530.
  • 51
    Buckley CD et al. Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium. J Immunol 2000;165: 34239.
  • 52
    Inngjerdingen M, Damaj B, Maghazachi AA. Expression and regulation of chemokine receptors in human natural killer cells. Blood 2001;97: 36775.
  • 53
    Chen S et al. TGF-beta1 upregulates CX3CR1 expression and inhibits fractalkine-stimulated signaling in rat microglia. J Neuroimmunol 2002;133: 4655.
  • 54
    Han Y et al. TGFbeta1 selectively up-regulates CCR1 expression in primary murine astrocytes. Glia 2000;30: 110.
  • 55
    Wenzel SE et al. TGF-beta and IL-13 synergistically increase eotaxin-1 production in human airway fibroblasts. J Immunol 2002;169: 46139.
  • 56
    Zhu Z et al. IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol 2002;168: 295362.
  • 57
    Lordan JL et al. Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells. J Immunol 2002;169: 40714.
  • 58
    Yamamoto H et al. Cyclic stretch upregulates interleukin-8 and transforming growth factor-beta1 production through a protein kinase C-dependent pathway in alveolar epithelial cells. Respirology 2002;7: 1039.
  • 59
    Rabin RL et al. Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling. J Immunol 1999;162: 384050.
  • 60
    Taub DD et al. Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells. J Exp Med 1993;177: 180914.
  • 61
    Utsunomiya I et al. Differential expression of binding sites for chemokine RANTES on human T lymphocytes. Eur J Immunol 1997;27: 140612.
  • 62
    Loetscher P et al. Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes. J Exp Med 1996;184: 56977.
  • 63
    Johnston JA et al. Human T lymphocyte chemotaxis and adhesion induced by vasoactive intestinal peptide. J Immunol 1994;153: 17628.
  • 64
    Peacock JW, Jirik FR. TCR activation inhibits chemotaxis toward stromal cell-derived factor-1: evidence for reciprocal regulation between CXCR4 and the TCR. J Immunol 1999;162: 21523.
  • 65
    Berlin C et al. Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 1993;74: 1855.
  • 66
    Parker CM et al. A family of beta 7 integrins on human mucosal lymphocytes. Proc Natl Acad Sci USA 1992;89: 19248.
  • 67
    Lefrancois L et al. Developmental expression of the alpha IEL beta 7 integrin on T cell receptor gamma delta and T cell receptor alpha beta T cells. Eur J Immunol 1994;24: 63540.
  • 68
    Baumgart M et al. Increase in the expression of alpha E beta 7, characteristic of intestinal intraepithelial lymphocytes, on T cells in the lung epithelium of patients with interstitial lung diseases and in synovial fluid of patients with rheumatic diseases. Immunobiology 1996;196: 41524.
  • 69
    Pauls K et al. Role of integrin alphaE(CD103)beta7 for tissue-specific epidermal localization of CD8+ T lymphocytes. J Invest Dermatol 2001;117: 56975.
  • 70
    Trollmo C et al. Expression of the mucosal lymphocyte integrin alpha E beta 7 and its ligand E-cadherin in the synovium of patients with rheumatoid arthritis. Scand J Immunol 1996;44: 2938.
  • 71
    Fujihara T et al. Preferential localization of CD8+ alpha E beta 7+ T cells around acinar epithelial cells with apoptosis in patients with Sjogren's syndrome. J Immunol 1999;163: 222635.
  • 72
    Karecla PI et al. Recognition of E-cadherin on epithelial cells by the mucosal T cell integrin alpha M290 beta 7 (alpha E beta 7). Eur J Immunol 1995;25: 8526.
  • 73
    Schon MP et al. Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice. J Immunol 1999;162: 66419.
  • 74
    Robinson PW et al. Studies on transcriptional regulation of the mucosal T-cell integrin alphaEbeta7 (CD103). Immunology 2001;103: 14654.
  • 75
    Andrew DP et al. Distribution of alpha 4 beta 7 and alpha E beta 7 integrins on thymocytes, intestinal epithelial lymphocytes and peripheral lymphocytes. Eur J Immunol 1996;26: 897905.
  • 76
    Kilshaw PJ, Murant SJ. Expression and regulation of beta 7(beta p) integrins on mouse lymphocytes: relevance to the mucosal immune system. Eur J Immunol 1991;21: 25917.
  • 77
    Wong WK et al. Tubulitis in renal allograft rejection: role of transforming growth factor-beta and interleukin-15 in development and maintenance of CD103+ intraepithelial T cells. Transplantation 2003;75: 50514.
  • 78
    Picker LJ et al. ELAM-1 is an adhesion molecule for skin-homing T cells. Nature 1991;349: 7969.
  • 79
    Shieh CC et al. Lymphocyte adhesion to epithelia and endothelia mediated by the lymphocyte endothelial-epithelial cell adhesion molecule glycoprotein. J Immunol 1999;163: 1592601.
  • 80
    Walton LJ et al. Cutaneous lymphocyte associated antigen (CLA) and alpha e beta 7 integrins are expressed by mononuclear cells in skin and oral lichen planus. J Oral Pathol Med 1997;26: 4027.
  • 81
    De Vries IJ et al. Nonspecific T-cell homing during inflammation in atopic dermatitis: expression of cutaneous lymphocyte-associated antigen and integrin alphaE beta7 on skin-infiltrating T cells. J Allergy Clin Immunol 1997;100: 694701.
  • 82
    Sigmundsdottir H et al. The frequency of CLA+CD8+ T cells in the blood of psoriasis patients correlates closely with the severity of their disease. Clin Exp Immunol 2001;126: 3659.
  • 83
    Lim SP, Leung E, Krissansen GW. The beta7 integrin gene (Itgb-7) promoter is responsive to TGF-beta1: defining control regions. Immunogenetics 1998;48: 18495.
  • 84
    Gorelik L, Flavell RA. Transforming growth factor-beta in T-cell biology. Nat Rev Immunol 2002;2: 4653.
  • 85
    Kullberg MC et al. Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism. Infect Immun 1998;66: 515766.
  • 86
    Monteleone G et al. Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. J Clin Invest 2001;108 (4):6019.
  • 87
    Bright JJ, Kerr LD, Sriram S. TGF-beta inhibits IL-2-induced tyrosine phosphorylation and activation of Jak-1 and Stat 5 in T lymphocytes. J Immunol 1997;159: 17583.
  • 88
    Gilbert KM et al. Transforming growth factor-beta 1 induces antigen-specific unresponsiveness in naive T cells. Immunol Invest 1997;26: 45972.
  • 89
    Fargeas C et al. Differential effect of transforming growth factor beta on the synthesis of Th1- and Th2-like lymphokines by human T lymphocytes. Eur J Immunol 1992;22: 21736.
  • 90
    Nagelkerken L et al. Role of transforming growth factor-beta in the preferential induction of T helper cells of type 1 by staphylococcal enterotoxin B. Eur J Immunol 1993;23: 230610.
  • 91
    Takeuchi M, Alard P, Streilein JW. TGF-beta promotes immune deviation by altering accessory signals of antigen-presenting cells. J Immunol 1998;160: 158997.
  • 92
    Zhang X et al. Control of CD4 effector fate: transforming growth factor beta 1 and interleukin 2 synergize to prevent apoptosis and promote effector expansion. J Exp Med 1995;182: 699709.
  • 93
    Stevens SR et al. Suppressor T cell-activating macrophages in ultraviolet-irradiated human skin induce a novel, TGF-beta-dependent form of T cell activation characterized by deficient IL-2r alpha expression. J Immunol 1995;155: 56017.
  • 94
    Bonham CA et al. TGF-beta 1 pretreatment impairs the allostimulatory function of human bone marrow-derived antigen-presenting cells for both naive and primed T cells. Transpl Immunol 1996;4: 18691.
  • 95
    King C et al. TGF-beta1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype. Immunity 1998;8: 60113.
  • 96
    Takeuchi M et al. On the mechanisms by which transforming growth factor-beta 2 alters antigen-presenting abilities of macrophages on T cell activation. Eur J Immunol 1997;27: 164856.
  • 97
    Hoehn P et al. Opposing effects of TGF-beta 2 on the Th1 cell development of naive CD4+ T cells isolated from different mouse strains. J Immunol 1995;155: 378893.
  • 98
    Westermann J, Bode U. Distribution of activated T cells migrating through the body: a matter of life and death. Immunol Today 1999;20: 3026.
  • 99
    Bode U, Sparmann G, Westermann J. Gut-derived effector T cells circulating in the blood of the rat: preferential re-distribution by TGFbeta-1 and IL-4 maintained proliferation. Eur J Immunol 2001;31: 211625.
  • 100
    Sung JL, Lin JT, Gorham JD. CD28 co-stimulation regulates the effect of transforming growth factor-beta1 on the proliferation of naive CD4(+) T cells. Int Immunopharmacol 2003;3: 23345.
  • 101
    Yamashiro H et al. Hierarchical signaling thresholds determine the fates of naive T cells: partial priming leads naive T cells to unresponsiveness. Biochem Biophys Res Commun 2002;299: 14854.
  • 102
    Constant SL, Bottomly K. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol 1997;15: 297322.
  • 103
    Rogers PR, Croft M. Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance. J Immunol 1999;163: 120513.
  • 104
    Reynisdottir S, Sigmundsdottir H, Gudjonsson, JE, Valdimarsson H, Ludriksson BR. TGF-beta 1 has preferential tolerogenic effects on peripheral CD8+ T cells after prolonged stimulation (Meeting Abstract). J Allergy Clin Immunol 2002;109: 986(Suppl. S).
  • 105
    Baecher-Allan C, Viglietta V, Hafler DA. Inhibition of human CD4(+)CD25(+high) regulatory T cell function. J Immunol 2002;169: 62107.
  • 106
    Mamura M et al. Ligation of the T cell receptor complex results in phosphorylation of Smad2 in T lymphocytes. Biochem Biophys Res Commun 2000;268: 1247.