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Keywords:

  • Cohn Fraction III;
  • mannan binding lectin;
  • plasma fractionation;
  • serum amyloid P

Cohn Fraction III, a waste product of plasma fractionation, is a source of several proteins involved in host defence as part of the innate immune system. Here a procedure is described for purifying mannan binding lectin and serum amyloid P component to virtual homogeneity from Cohn Fraction I + III, and their separation from other mannan-binding factors and from C-reactive protein. It is suggested that products derived from Cohn Fraction III could have therapeutic potential, either for specific substitution therapy or as a combined package of innate immune factors.