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Which intercurrent infections are associated with maculopapular cutaneous drug reactions? A case-control study

Authors

  • Arnon D. Cohen MD,

    1. From the Departments of Dermatology and Epidemiology and Health Services Evaluation, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
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  • Michael Friger PhD,

    1. From the Departments of Dermatology and Epidemiology and Health Services Evaluation, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
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  • Batia Sarov PhD, MPH,

    1. From the Departments of Dermatology and Epidemiology and Health Services Evaluation, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
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  • Sima Halevy MD

    1. From the Departments of Dermatology and Epidemiology and Health Services Evaluation, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
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Arnon Cohen, md
Department of Dermatology
Soroka University Medical Center
Beer-Sheva
84101, Israel

Abstract

Abstract

Background  Patients with lymphotrophic viral infections are at increased risk for cutaneous drug reactions (CDRs). However, the association between other intercurrent infections and maculopapular CDRs has not been evaluated by epidemiologic methods.

Objective  We conducted a case-control study in order to evaluate the exposure to intercurrent infections in patients with maculopapular CDRs.

Methods  Data were obtained through assessment of files of 53 patients hospitalized for maculopapular CDRs in the Department of Dermatology and 159 control patients. Exposure to intercurrent infections was recorded in patients and controls.

Results  An intercurrent infectious disease was documented in 31/53 (58.5%) of patients with CDRs, as compared to 12/159 (7.5%) patients in the control group (OR 17.26, 95% CI: 7.24–42.00). Maculopapular CDRs were associated with respiratory tract infections (OR 20.53, 95% CI: 5.20–94.45), and urinary tract infections (OR 20.61, 95% CI: 2.36–465.99), but not with skin infections (OR 3.83, 95% CI: 0.85–17.87) or other infections.

Conclusions  Our study implies that maculopapular CDRs are associated with respiratory tract infections as well as urinary tract infections. Further study is needed to evaluate the role of intercurrent infections in the pathogenesis of CDRs.

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