TNFα and IL-6 are mediators in the blistering process of pemphigus
Article first published online: 21 DEC 2001
International Journal of Dermatology
Volume 40, Issue 3, pages 185–188, March 2001
How to Cite
López-Robles, E., Avalos-Díaz, E., Vega-Memije, E., Hojyo-Tomoka, T., Villalobos, R., Fraire, S., Domíguez-Soto, L. and Herrera-Esparza, R. (2001), TNFα and IL-6 are mediators in the blistering process of pemphigus. International Journal of Dermatology, 40: 185–188. doi: 10.1046/j.1365-4362.2001.01083.x
- Issue published online: 21 DEC 2001
- Article first published online: 21 DEC 2001
Background Pemphigus is an autoimmune disease characterized by intraepidermal blisters induced by pemphigus IgG. In addition to autoantibodies, molecular mechanisms involved in acantholysis remain largely unknown. For this reason, we address a possible role of the inflammatory cytokines IL-6 and TNFα in pemphigus lesions.
Methods Sixteen biopsies from patients with different types of pemphigus were studied by in situ hybridization using DNA fluorescent probes for IL-6 and TNFα mRNA.
Results Fifty-six percent of lesional biopsies exhibited cytokine gene expression, which was poorly expressed in noninvolved skin. Deposits of TNFα and IL-6 were products of in situ transcription at the epidermal level.
Conclusions Inflammatory cytokine expression around the blister could play a mediator role in pemphigus lesions by increasing epithelial damage.