Drug names cyclosporin A: Sandimmune, Sandimune Neoral®
Lymphocyte subtypes and adhesion molecules in actinic prurigo: observations with cyclosporin A
Article first published online: 14 MAY 2002
International Journal of Dermatology
Volume 41, Issue 3, pages 139–145, March 2002
How to Cite
Umaña, A., Gómez, A., Durán, M. M. and Porras, L. (2002), Lymphocyte subtypes and adhesion molecules in actinic prurigo: observations with cyclosporin A. International Journal of Dermatology, 41: 139–145. doi: 10.1046/j.1365-4362.2002.01419.x
- Issue published online: 14 MAY 2002
- Article first published online: 14 MAY 2002
Background Actinic prurigo is a photodermatitis in which UV light is implicated by an unknown mechanism.
Methods Skin biopsies of 19 patients with actinic prurigo and 11 controls were analyzed by immunohistochemistry.
Results In actinic prurigo patients, there was a significant increase in the number of CD3, CD4, CD8, CD45RA, CD45RO, and CD45RB lymphocytes and Langerhans cells, as well as in the level of human leukocyte antigen-DR (HLA-DR) expression and cell adhesion molecules lymphocyte functional antigen-1 (LFA-1), intercellular adhesion molecule-1 (ICAM-1), and endothelial leukocyte adhesion molecule-1 (ELAM-1). Actinic prurigo patients were treated with cyclosporin A (CsA), and a final skin biopsy was taken after 6 months of treatment. All the cell populations and markers studied, except for the CD4 lymphocytes, Langerhans cells, and HLA-DR expression, returned to normal levels.
Conclusions CsA was found to be effective in relieving the clinical symptoms of actinic prurigo.