An open-label study of the safety and efficacy of limited application of fluticasone propionate ointment, 0.005%, in patients with atopic dermatitis of the face and intertriginous areas

Authors

  • Mei-Heng Tan MD,

    1. From the Department of Dermatology, The Mount Sinai School of Medicine of New York University, New York
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  • Stacie L. Meador BA,

    1. From the Department of Dermatology, The Mount Sinai School of Medicine of New York University, New York
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  • Giselle Singer BS,

    1. From the Department of Dermatology, The Mount Sinai School of Medicine of New York University, New York
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  • Mark G. Lebwohl MD

    Corresponding author
    1. From the Department of Dermatology, The Mount Sinai School of Medicine of New York University, New York
      Mark G. Lebwohl, md The Mount Sinai School of Medicine Department of Dermatology One Gustave L. Levy Place New York, NY 10029
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Mark G. Lebwohl, md The Mount Sinai School of Medicine Department of Dermatology One Gustave L. Levy Place New York, NY 10029

Abstract

Background The treatment options for facial and intertriginous skin are limited because these sites are more susceptible to corticosteroid-induced atrophy. The long-term management of these corticosteroid-sensitive sites requires the use of dosing regimens that are effective, but also safe.

Methods The affected areas in 21 patients with atopic dermatitis were treated twice daily for 2 weeks, and then once daily for two consecutive days each week for eight more weeks.

Results After 2 weeks, treatment success occurred in 95% of facial and intertriginous lesions and also in 95% of nonfacial, nonintertriginous lesions. During long-term therapy, treatment success was maintained in > 76% of facial and intertriginous lesions, and > 76% of other lesions. Recurrence rates were low, and skin atrophy and telangiectasia did not occur.

Conclusions Patients with atopic dermatitis of facial and intertriginous areas were successfully treated with a limited application of fluticasone propionate ointment, 0.005%. The treatment resulted in rapid healing and provided efficacy with a low rate of recurrence and no evidence of skin atrophy or telangiectasia over 8 weeks.

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